Generic Name: doxepin (DOX-e-pin)
Brand Name: Sinequan
Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using doxepin capsules outweigh the risks.
Family and caregivers must closely watch patients who take doxepin capsules. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.
Doxepin capsules are not approved for use in children. Talk with the doctor.
Doxepin capsules are used for:
Treating depression or anxiety in certain patients. It may also be used for other conditions as determined by your doctor.
Doxepin capsules are a tricyclic antidepressant. Exactly how it works is not known. It may increase the activity of certain chemicals in the brain that help elevate mood.
Do NOT use doxepin capsules if:
- you are allergic to any ingredient in doxepin capsules or to other tricyclic antidepressants
- you have glaucoma or trouble urinating
- you have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, furazolidone, phenelzine, isocarboxazid) within the past 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using doxepin capsules:
Some medical conditions may interact with doxepin capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems, seizures (eg, epilepsy), overactive thyroid, prostate problems (eg, benign prostatic hypertrophy [BPH]), blood problems (eg, porphyria), increased eye pressure, other mental or mood problems, suicidal thoughts or attempts, or alcohol abuse
- if you are taking a medicine that contains methylene blue
Some MEDICINES MAY INTERACT with doxepin capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Antiarrhythmics (eg, quinidine, propafenone, flecainide), antifungal medicines (eg, fluconazole, terbinafine), carbamazepine, cimetidine, mibefradil, phenothiazines (eg, chlorpromazine, thioridazine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, sertraline) because they may increase the risk of doxepin capsules's side effects
- Anticoagulants (eg, warfarin), H1 antagonists (eg, astemizole, terfenadine), ibutilide, sulfonylureas (eg, tolazamide, glipizide), sympathomimetics (eg, phenylephrine, pseudoephedrine), or tramadol because the risk of their side effects may be increased by doxepin capsules
- Clonidine, guanadrel, guanethidine, or guanfacine because their effectiveness may be decreased by doxepin capsules
- Linezolid or MAOIs (eg, furazolidone, phenelzine, isocarboxazid) because severe toxic effects may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if doxepin capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use doxepin capsules:
Use doxepin capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Doxepin capsules comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get doxepin capsules refilled.
- Take doxepin capsules by mouth with or without food.
- Taking doxepin capsules at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.
- If you miss a dose of doxepin capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.
Ask your health care provider any questions you may have about how to use doxepin capsules.
Important safety information:
- Doxepin capsules may cause drowsiness, dizziness, blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use doxepin capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Doxepin capsules may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using doxepin capsules; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Children, teenagers, and young adults who take doxepin capsules may be at increased risk for suicidal thoughts or actions. Watch all patients who take doxepin capsules closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
- Some people may be at risk for eye problems from doxepin capsules. Your doctor may want you to have an eye exam to see if you are at risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, or swelling or redness in or around the eye.
- Doxepin capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to doxepin capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Tell your doctor or dentist that you take doxepin capsules before you receive any medical or dental care, emergency care, or surgery.
- After you start taking doxepin capsules, several weeks may pass before you feel the full benefit.
- Use doxepin capsules with caution in the ELDERLY; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using doxepin capsules while you are pregnant. Doxepin capsules are found in breast milk. Do not breast-feed while taking doxepin capsules.
Possible side effects of doxepin capsules:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Appetite loss; constipation; diarrhea; dizziness; drowsiness; dry mouth; excess sweating; headache; heartburn; increased appetite; indigestion; nausea; unpleasant taste; urinary retention; vomiting; weakness; weight gain.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal movements; aggressive or bizarre behavior; agitation; anxiety; chest pain; difficulty speaking and swallowing; disorientation; eye pain; fainting; fast, slow, or irregular heartbeat; hair loss; hallucinations; hostility; irritability; loss of balance; mood swings; nervousness or restlessness; panic attacks; ringing in the ears; seizures; shakiness; sore throat or fever; trouble sleeping; twitching of the face or tongue; unusual bleeding or bruising; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of doxepin capsules:
Store doxepin capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep doxepin capsules out of the reach of children and away from pets.
- If you have any questions about doxepin capsules, please talk with your doctor, pharmacist, or other health care provider.
- Doxepin capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take doxepin capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about doxepin capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to doxepin capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using doxepin capsules.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about doxepin
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 226 Reviews – Add your own review/rating
- Drug class: miscellaneous anxiolytics, sedatives and hypnotics