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Zolpidem use while Breastfeeding

Drugs containing Zolpidem: Ambien, Ambien CR, Zolpimist, Edluar, Intermezzo

Medically reviewed by Drugs.com. Last updated on Feb 28, 2021.

Zolpidem Levels and Effects while Breastfeeding

Summary of Use during Lactation

Little information is available on the use of zaleplon during breastfeeding. Some expert opinion considers zaleplon to be not recommended during breastfeeding.[1,2] Because of the low levels of zolpidem in breastmilk and its short half-life, amounts ingested by the infant are small and would not be expected to cause any adverse effects in older breastfed infants. Monitor infants for excess sedation, hypotonia, and respiratory depression.

Drug Levels

Maternal Levels. Five nursing mothers who were 3 to 4 days postpartum were given a single oral dose of zolpidem 20 mg. Milk collected 3 hours after the dose contained between 0.76 and 3.88 mcg of zolpidem. This corresponded to 0.004 to 0.019% of the maternal dosage. The drug was undetectable (<0.5 mcg/L) in milk 13 and 16 hours after the dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Zaleplon

References

1.
Uguz F. A new safety scoring system for the use of psychotropic drugs during lactation. Am J Ther. 2021;28:e118–e26. [PubMed: 30601177]
2.
Picchietti DL, Hensley JG, Bainbridge JL, et al. Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev. 2015;22:64–77. [PubMed: 25553600]
3.
Pons G, Francoual C, Guillet P, et al. Zolpidem excretion in breast milk. Eur J Clin Pharmacol. 1989;37:245–8. [PubMed: 2612539]

Substance Identification

Substance Name

Zolpidem

CAS Registry Number

82626-48-0

Drug Class

Breast Feeding

Lactation

Hypnotics and Sedatives

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Further information

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