Skip to Content

Hydrocodone and ibuprofen

Generic Name: hydrocodone and ibuprofen (HYE dro KOE done and EYE bue pro fen)
Brand Name: Ibudone, Reprexain, Xylon 10, Vicoprofen

Medically reviewed on Dec 12, 2017

What is hydrocodone and ibuprofen?

Hydrocodone is an opioid pain medication, sometimes called a narcotic. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). hydrocodone and ibuprofen works by reducing substances in the body that cause pain, fever, and inflammation.

Hydrocodone and ibuprofen is a combination medicine that is used short-term to relieve severe pain.

Hydrocodone and ibuprofen may also be used for purposes not listed in this medication guide.

Important Information

Hydrocodone can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using ibuprofen, especially in older adults.

Before taking this medicine

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking hydrocodone and ibuprofen.

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use this medicine if you are allergic to hydrocodone or ibuprofen (Advil, Motrin), or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • heart disease, high blood pressure, fluid retention, diabetes, or if you smoke;

  • stomach ulcers, or bleeding in your stomach or intestines;

  • asthma or other breathing problems;

  • liver or kidney disease;

  • a head injury, brain tumor, or seizures;

  • a problem with your gallbladder, pancreas, thyroid, or adrenal gland;

  • urination problems; or

  • drug or alcohol addiction, or mental illness.

Some medicines can interact with hydrocodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

If you use hydrocodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant.

This medicine can pass into breast milk and cause drowsiness or breathing problems in a nursing baby. You should not breast-feed while using this medicine.

How should I take hydrocodone and ibuprofen?

Follow all directions on your prescription label. Hydrocodone can slow or stop your breathing. Never take this medicine in larger amounts, or for longer than prescribed. Use the lowest dose that is effective in treating your condition. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Hydrocodone may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away hydrocodone and ibuprofen is against the law.

If you need surgery, tell the surgeon ahead of time that you are using hydrocodone and ibuprofen.

Store at room temperature away from moisture and heat. Keep track of your medicine. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

What happens if I miss a dose?

Since hydrocodone and ibuprofen is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A hydrocodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include vomiting, black or bloody stools, coughing up blood, confusion, muscle weakness, cold and clammy skin, slow heart rate, blue lips, noisy or shallow breathing, or coma.

What should I avoid while taking hydrocodone and ibuprofen?

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how the medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Do not drink alcohol. Dangerous side effects or death could occur.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many combination medicines contain aspirin or other medicines similar to ibuprofen. Taking certain products together can cause you to get too much of this type of medicine.

Hydrocodone and ibuprofen side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.

Stop using hydrocodone and ibuprofen and call your doctor at once if you have:

  • weak or shallow breathing, sighing, slow heartbeat;

  • shortness of breath (even with mild exertion), swelling or rapid weight gain;

  • the first sign of any skin rash, no matter how mild;

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems--loss of appetite, diarrhea, upper stomach pain, tiredness, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes);

  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

  • low cortisol levels--vomiting, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Hydrocodone and ibuprofen dosing information

Usual Adult Dose for Pain:

1 tablet orally every 4 to 6 hours as needed
Maximum dose: 5 tablets in 24 hours
Duration of therapy: Generally less than 10 days

Comments:
-The lowest effective dose or the longest dosing interval should be sought for each patient.
-Each tablet provides a combination of ibuprofen 200 mg and either hydrocodone 2.5, 5, 7.5, or 10 mg.
-Because of the risks of addiction and abuse, this drug should be reserved for use in patients for whom alternative treatment options have not been tolerated, or are not expected to be tolerated; or have not provided adequate analgesia, or are not expected to provide adequate analgesia.

Use: For the short-term management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Usual Pediatric Dose for Pain:

16 years or older:

1 tablet orally every 4 to 6 hours as needed
Maximum dose: 5 tablets in 24 hours
Duration of therapy: Generally less than 10 days

Comments:
-The lowest effective dose or the longest dosing interval should be sought for each patient.
-Each tablet provides a combination of ibuprofen 200 mg and either hydrocodone 2.5, 5, 7.5, or 10 mg.
-Because of the risks of addiction and abuse, this drug should be reserved for use in patients for whom alternative treatment options have not been tolerated, or are not expected to be tolerated; or have not provided adequate analgesia, or are not expected to provide adequate analgesia.

Use: For the short-term management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

What other drugs will affect hydrocodone and ibuprofen?

Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete. Other drugs may interact with hydrocodone and ibuprofen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide