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Diphenhydramine and magnesium salicylate

Generic name: diphenhydramine and magnesium salicylate (DYE fen HYE dra meen and mag NEE ze um sa LIS a late)
Brand name: Doans PM
Dosage forms: oral tablet (25 mg-580 mg)
Drug class: Analgesic combinations

Medically reviewed by Drugs.com on Oct 19, 2020. Written by Cerner Multum.

What is diphenhydramine and magnesium salicylate?

Diphenhydramine is an antihistamine sometimes used as a sleep aid. Magnesium salicylate is a nonsteroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates).

Diphenhydramine and magnesium salicylate is a combination medicine that is used to treat back pain that keeps you awake during your normal sleeping hours.

Diphenhydramine and magnesium salicylate may also be used for purposes not listed in this medication guide.

Warnings

Use diphenhydramine and magnesium salicylate exactly as directed. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Magnesium salicylate may cause stomach or intestinal bleeding, which can be fatal. Call your doctor at once if you have symptoms of stomach bleeding such as dizziness, black or bloody stools, or coughing up blood.

Ask a doctor before giving the medicine to a child younger than 12 years old. Do not give this medicine to a child or teenager with a fever, flu symptoms, or chickenpox. Do not use this medicine to make a child sleepy.

Before taking this medicine

You should not use this medicine if you are allergic to aspirin or other salicylates.

Do not give this medicine to a child or teenager with a fever, flu symptoms, or chickenpox. Salicylates can cause Reye's syndrome, a serious and sometimes fatal condition in children. Ask a doctor before giving the medicine to a child younger than 12 years old.

Magnesium salicylate may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using magnesium salicylate, especially in older adults.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Taking this medicine during the last 20 weeks of pregnancy may cause serious kidney problems in the unborn baby, or bleeding in the mother or the baby during delivery.

How should I take diphenhydramine and magnesium salicylate?

Use exactly as directed on the label, or as prescribed by your doctor.

Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Take diphenhydramine and magnesium salicylate with a full glass of water before bedtime.

Take with food if this medicine upsets your stomach.

Do not use this medicine to make a child sleepy.

Stop taking this medicine and call your doctor if your pain does not improve, or if it gets worse after 10 days of using this medicine. Tell your doctor if you have a fever that lasts longer than 3 days, or if you have any redness or swelling.

If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using diphenhydramine and magnesium salicylate. You may need to stop using the medicine for a short time.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using diphenhydramine and magnesium salicylate.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diphenhydramine can be fatal.

Overdose symptoms may include vomiting, confusion, severe drowsiness, ringing in your ears, no urination, very dry eyes and mouth, dilated pupils, fast heartbeats, tremor, agitation, hallucinations, or seizure.

What should I avoid while taking diphenhydramine and magnesium salicylate?

Avoid driving or hazardous activity until you know how diphenhydramine and magnesium salicylate will affect you. Your reactions could be impaired.

Also ask a doctor or pharmacist before using any other medicine that may contain diphenhydramine or ingredients similar to magnesium salicylate (such as aspirin or other salicylates). This includes medicines for pain, fever, swelling, sleep, cold/allergy symptoms, or anti-itch medicine used on the skin. Using too much diphenhydramine may lead to a fatal overdose.

Avoid alcohol. Heavy drinking can increase your risk of stomach bleeding.

Diphenhydramine and magnesium salicylate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe drowsiness;

  • painful or difficult urination;

  • ringing in your ears, hearing loss;

  • confusion; or

  • signs of stomach bleeding--feeling light-headed, ongoing stomach pain, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

  • drowsiness;

  • dry eyes, blurred vision;

  • dry mouth, nose, or throat;

  • decreased urination;

  • heartburn, nausea, vomiting, gas;

  • constipation;

  • feeling restless or excited (especially in children); or

  • day-time drowsiness or "hangover" feeling after night-time use.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Diphenhydramine and magnesium salicylate dosing information

Usual Adult Dose for Insomnia:

Diphenhydramine-magnesium salicylate 25 mg-580 mg oral tablet:
2 tablets orally at bedtime as needed with a full glass of water.

Usual Adult Dose for Pain:

Diphenhydramine-magnesium salicylate 25 mg-580 mg oral tablet:
2 tablets orally at bedtime as needed with a full glass of water.

Usual Pediatric Dose for Insomnia:

Diphenhydramine-magnesium salicylate 25 mg-580 mg oral tablet:
12 years or older: 2 tablets orally at bedtime as needed with a full glass of water.

Usual Pediatric Dose for Pain:

Diphenhydramine-magnesium salicylate 25 mg-580 mg oral tablet:
12 years or older: 2 tablets orally at bedtime as needed with a full glass of water.

What other drugs will affect diphenhydramine and magnesium salicylate?

Ask a doctor or pharmacist before using diphenhydramine and magnesium salicylate with any other drugs that can cause drowsiness (such as opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures).

Ask a doctor or pharmacist if it is safe for you to use diphenhydramine and magnesium salicylate if you are also using:

This list is not complete. Other drugs may affect diphenhydramine and magnesium salicylate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does Diphenhydramine/magnesium salicylate interact with my other drugs?

Enter other medications to view a detailed report.

More about diphenhydramine / magnesium salicylate

Consumer resources

Other brands
Doans PM

Related treatment guides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.