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Tylenol (acetaminophen) Drug Interactions

A total of 181 drugs are known to interact with Tylenol (acetaminophen).

  • 14 major drug interactions
  • 73 moderate drug interactions
  • 94 minor drug interactions

Show all medications in the database that may interact with Tylenol (acetaminophen).

Check for interactions

Type in a drug name to check for interactions with Tylenol (acetaminophen).

Most frequently checked interactions

View interaction reports for Tylenol (acetaminophen) and the medicines listed below.

  • Advil (ibuprofen)
  • albuterol (Ventolin, Ventolin HFA, ProAir HFA, Proventil, Proventil HFA, ProAir RespiClick, AccuNeb, Respirol, Vospire ER, Volmax, ProAir Digihaler, Airet)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Benadryl (diphenhydramine)
  • caffeine (Vivarin, Stay Awake, NoDoz, Jet Alert Regular Strength, Jet Alert Maximum Strength, Caffedrine, Alert, Diurex Ultra, Cafcit, Jet Alert Double Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, 357 HR Magnum, Enerjets, Fastlene, Keep Going, Molie, Overtime, Valentine)
  • codeine
  • diclofenac (Voltaren, Cataflam, Cambia, Zorvolex, Zipsor, Voltaren-XR, Dyloject)
  • Eliquis (apixaban)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lasix (furosemide)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • MiraLax (polyethylene glycol 3350)
  • Mucinex (guaifenesin)
  • multivitamin (Daflon, Metanx, Neurobion, Vitamins, Theragran, Vitamin B Complex 100, Cerefolin NAC, Cerefolin, Rena-Vite, Folbic, Foltx, Estroven, Nephro-Vite, Lipoflavonoid, Folbee, Foltanx, Thera, Super B Complex, MVI Adult, Nephrocaps, PoDiaPN, Folic Acid XTRA, Tab-A-Vite, Cod Liver Oil Mint, B Complex 100, Triphrocaps, FaBB, Nufola, Nephro-Vite Rx, Cod Liver Oil, Multi Vitamin+, Rheumate, Renal Caps, Essentiale, Berocca, Daily Vite, Rena-Vite Rx, Xyzbac, Lysiplex, Flintstones Multivitamins, Surbex, Super B-50, Fletanol, Infuvite, Infuvite Pediatric, Folcaps, Folinic-Plus, StressTabs, Reno Caps, Surbex with C, Folika-T, Apetigen, Stress Formula, B Complex 50, Cernevit, Vitamin Daily Liquid, Topfit Vitamin B Complex, Vitamin B Compound Strong, Nephronex, Folgard RX, One-A-Day Men's Health Formula, Folplex, Nephplex Rx, Metafolbic Plus, Virt-Caps, Therems, Daily Multiple Vitamins, Childrens Chewable Multivitamins, Vitacirc-B, One-A-Day Essentials, Essential Balance, Flintstones with C Multivitamins, Stress B with C, Theravite, Thera-Plus, High Potency B Complex with B12 and C, Super B-100 TD, L-methylfolate Ca, Me-Cbl NAC, Theragenerix, Apetex, Folastin, Topfit Vitamin B Complex Forte, L-Methyl-B6-B12, Jetepar, Vitamin A and D Concentrate, Centrum 8400, Foltabs 800, Menopause Relief with Lifenol, Daily-Vite Men's Formula, Biotin Forte, Vimar, B 100 Complex, Vol-Care Rx, Folbic RF, Foltanx RF, Mebolex, Mebolic, B-Plex, Vitaplex, Metafolbic, Stress-600, Thera-Tabs, Vi-Daylin, Poly-Vi-Sol, Watkins Harvest, Balanced B-100, B-Stress, B-Scorbic, Bee with C, Balanced B-50, Nat-Rul B-125, Balanced B-150, Unicap Capsule, Unicap Jr, Unicap, Optilets-500, Super Plenamins, Vitamins for Hair, Vi-Daylin Chewable, Folast, Enfolast, Sunkist Child Chewable with C, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Fruity Chew, Triphro, Poly-Vit Chew, Vita-Respa, Chewable-Vite, Bugs Bunny with Extra C, Geravine, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Poly-Vi-Sol Drops, Baby Vitamin Drop, Vita Drop, Poly Vit Drops, MVC SDV, Glutofac, Allbee-C, Vitabee with C, High Potency B+C, Av-VITE FB, Farbee with C, Mynephron, Renatabs, Tri-Vitamin, DEKAs Essential, Vitamin B-50, Vitamin B-100, D-400 international units, Vitamin B-100 T/R, Hexavitamin, Celebrate B-12, Kenwood Therapeutic, Oncovite, Glycogenics, Beminal-500, Tri-Vit Drops, Flintstones Toddler, One Tab Daily, Vitamin C, E, and Rose Hips, Scotts Emulsion, Stress Formula 600, Tri-Vit, Mega B, Apatate, T-Vites, Hylavite, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Prostate 2.4, MTX Support, Cardiotek, Beminal, Beminal with C Fortis, Full Spectrum B with C, Bugs Bunny Multiple Vitamins, Allbee with C, Prevital, Surbex Filmtab, Tender Age Vitamin ADC, Folgard Rx 2.2, Cernevit-12, SeroSyn, Diatx, Vitamin A, D, One-A-Day 50+, Thex Forte, Metafolbic Plus RF, Dosoquin, Protegra Cardio, Virt-Vite Plus, K2 Plus D3, Renaphro, Virt-Gard, Dialyvite Rx, L-Methyl-MC, Levomefolate Calcium-Algal Powder, VP-Vite Rx, Vesselvite, Folbee Plus, Combgen, Abidec, Unichem Multivitamin, Health Aid Multivitamin, AllanTex, One Daily Multi-Essential, Larobec, Foltrate, Cardiotek Rx, Folbalin Plus, Dialyvite 800, Folbalin, Multi-Delyn, Multi Vits with Beta Carotene, Foleve Plus, Folnate, Folnate Plus, B-Complex with B-12, Foleve, Hair, Skin, & Nails Gummies, Folamin, DexFol, Equaline One Daily Essential, Av-VITE FB Forte, Folmor, Zycose, Vigomar Forte, Allbee Plus, Triveen-CF, Nature's Bounty Hair Skin & Nails, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Methazel, Dyzbac, Mynephrocaps, Omega Q Plus, Acnepril, Super Theravite-M, Primaplex, Becomject-100, Poly-Vita Drops, MVI-12, B-Ject 100, L-Methyl-MC NAC, Therobec, Formula B, Tri-Vi-Sol, TL Gard, Vi-Daylin ADC, Lipogen, Nephrocaps QT, Virt-Vite, Lipotriad, Virt-Vite Forte, Folplex 2.2, Cholinoid, Tri-Vita Drops, Liponol, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, 1000 BC, Neurodep, Neuroforte-Six, MVI Pediatric, B-Plex Plus, Nephrolan Rx, Ivites Rx, Zymacap, Dayalets, Sigtab, Allbee-C 800, Cefol, B-Complex SR, Protegra, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Superplex-T, Vi-Stress, T-BMP, Animal Shape Vitamins, B-50 Complex, Niva-Fol)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • wine
  • Xarelto (rivaroxaban)
  • Zoloft (sertraline)

Tylenol (acetaminophen) alcohol/food interactions

There is 1 alcohol/food interaction with Tylenol (acetaminophen)

Tylenol (acetaminophen) disease interactions

There are 3 disease interactions with Tylenol (acetaminophen) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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