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Tylenol (acetaminophen) Drug Interactions

A total of 181 drugs are known to interact with Tylenol (acetaminophen).

  • 14 major drug interactions
  • 73 moderate drug interactions
  • 94 minor drug interactions

Show all medications in the database that may interact with Tylenol (acetaminophen).

Check for interactions

Type in a drug name to check for interactions with Tylenol (acetaminophen).

Most frequently checked interactions

View interaction reports for Tylenol (acetaminophen) and the medicines listed below.

  • Advil (ibuprofen)
  • albuterol (Ventolin HFA, Ventolin, ProAir HFA, Proventil, Proventil HFA, ProAir RespiClick, AccuNeb, Respirol, ProAir Digihaler, Vospire ER, Airet, Volmax)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Arthritis Pain, Bufferin, Ascriptin, Easprin, Fasprin, Aspergum, Empirin, Aspiritab, Bayer Children's Aspirin, Durlaza, Ascriptin Enteric, Entercote, Acuprin 81, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Halfprin, Ecotrin Adult Low Strength, Buffered Aspirin, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Ecotrin Maximum Strength, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Benadryl (diphenhydramine)
  • caffeine (Vivarin, Diurex Ultra, Caffedrine, Jet Alert Regular Strength, Jet Alert Maximum Strength, Stay Awake, Alert, 357 HR Magnum, Overtime, Valentine, NoDoz, Jet Alert Double Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, Cafcit, Enerjets, Fastlene, Keep Going, Molie)
  • codeine
  • diclofenac (Voltaren, Cataflam, Cambia, Zorvolex, Zipsor, Voltaren-XR, Dyloject)
  • Eliquis (apixaban)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Motrin IB, Proprinal, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Motrin Childrens, Rufen, Ibuprofen PMR, Ibu-8, Motrin Pediatric, Menadol, Nuprin, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, NeoProfen, Ibu-Tab, Genpril, Haltran, IBU-200, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lasix (furosemide)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Levothyrox, Euthyrox, Unithroid, L Thyroxine Roche, Levo-T, Oroxine, Eutroxsig, Novothyrox, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • metoprolol (Metoprolol Succinate ER, Metoprolol Tartrate, Lopressor, Toprol-XL, Kapspargo Sprinkle)
  • MiraLax (polyethylene glycol 3350)
  • Mucinex (guaifenesin)
  • multivitamin (Metanx, Daflon, Neurobion, Theragran, Vitamin B Complex 100, Rena-Vite, Vitamins, Nephro-Vite, Cerefolin, Folbic, Estroven, Cerefolin NAC, Nephrocaps, Foltx, Super B Complex, Rheumate, Renal Caps, Lipoflavonoid, Cod Liver Oil, B Complex 100, Folbee, PoDiaPN, Foltanx, Thera, Essentiale, Folic Acid XTRA, MVI Adult, Tab-A-Vite, Vitamin Daily Liquid, Topfit Vitamin B Complex, Folinic-Plus, Multi Vitamin+, Triphrocaps, Zyvit, Flintstones Multivitamins, Apetigen, Dosoquin, Rena-Vite Rx, Virt-Gard, Biotin Forte, Nufola, Omega Q Plus, Xyzbac, Metafolbic Plus, Lipogen, Chewable-Vite, Surbex, Theravite, Super B-50, MTX Support, Fletanol, Vitamin A, D, Apetex, L-Methyl-B6-B12, Nephronex, Foltrate, Nephro-Vite Rx, Thera-Tabs, Virt-Caps, Poly-Vi-Sol, Daily Multiple Vitamins, Cod Liver Oil Mint, Reno Caps, Unicap Capsule, Essential Balance, Lysiplex, Poly-Vi-Sol Drops, Stress B with C, Vitamin B-50, Folika-T, Vitamin B-100, Hexavitamin, Thera-Plus, High Potency B Complex with B12 and C, Flintstones Toddler, B Complex 50, Hylavite, Theragenerix, Prostate 2.4, Beminal, Bugs Bunny Multiple Vitamins, K2 Plus D3, Folastin, Levomefolate Calcium-Algal Powder, Folbee Plus, Vitamin B Compound Strong, Jetepar, Folgard RX, B-Complex with B-12, FaBB, One-A-Day Men's Health Formula, Vigomar Forte, Vimar, Genicin Vita-Q, Foltanx RF, Mebolex, Methazel, Berocca, Metafolbic, Folplex 2.2, 1000 BC, Neurodep, B-Plex Plus, Ivites Rx, Vi-Daylin, StressTabs, B-Complex SR, Daily Vite, Protegra, Superplex-T, T-BMP, Watkins Harvest, Balanced B-100, B-Stress, B-Scorbic, Bee with C, Childrens Chewable Multivitamins, Balanced B-50, Nat-Rul B-125, Balanced B-150, Unicap Jr, Vitacirc-B, Unicap, Optilets-500, Super Plenamins, Vitamins for Hair, One-A-Day Essentials, Vi-Daylin Chewable, Folast, Enfolast, Sunkist Child Chewable with C, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Fruity Chew, Triphro, Poly-Vit Chew, Vita-Respa, Bugs Bunny with Extra C, Flintstones with C Multivitamins, Geravine, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Baby Vitamin Drop, Vita Drop, Poly Vit Drops, MVC SDV, Glutofac, Allbee-C, Vitabee with C, High Potency B+C, Av-VITE FB, Farbee with C, Mynephron, Surbex with C, Renatabs, Tri-Vitamin, DEKAs Essential, D-400 international units, Vitamin B-100 T/R, Celebrate B-12, Kenwood Therapeutic, Oncovite, Glycogenics, Beminal-500, Super B-100 TD, Tri-Vit Drops, Stress Formula, One Tab Daily, Vitamin C, E, and Rose Hips, Scotts Emulsion, Stress Formula 600, Tri-Vit, Mega B, Apatate, T-Vites, L-methylfolate Ca, Me-Cbl NAC, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Cernevit, Cardiotek, Beminal with C Fortis, Full Spectrum B with C, Allbee with C, Prevital, Surbex Filmtab, Tender Age Vitamin ADC, Folgard Rx 2.2, Cernevit-12, SeroSyn, Infuvite, Infuvite Pediatric, Diatx, One-A-Day 50+, Thex Forte, Metafolbic Plus RF, Protegra Cardio, Virt-Vite Plus, Renaphro, Dialyvite Rx, L-Methyl-MC, VP-Vite Rx, Vesselvite, Folcaps, Combgen, Abidec, Unichem Multivitamin, Topfit Vitamin B Complex Forte, Health Aid Multivitamin, AllanTex, Vitamin A and D Concentrate, One Daily Multi-Essential, Centrum 8400, Larobec, Cardiotek Rx, Folbalin Plus, Dialyvite 800, Folbalin, Multi-Delyn, Multi Vits with Beta Carotene, Foleve Plus, Foltabs 800, Folnate, Folnate Plus, Foleve, Hair, Skin, & Nails Gummies, Folamin, DexFol, Equaline One Daily Essential, Menopause Relief with Lifenol, Daily-Vite Men's Formula, Av-VITE FB Forte, Folplex, Folmor, Zycose, Allbee Plus, Triveen-CF, B 100 Complex, Vol-Care Rx, Folika-V, Nature's Bounty Hair Skin & Nails, Genicin Vita-S, Tobakient, Folbic RF, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Mebolic, Dyzbac, Mynephrocaps, Acnepril, Super Theravite-M, Primaplex, Becomject-100, Poly-Vita Drops, MVI-12, Nephplex Rx, B-Ject 100, L-Methyl-MC NAC, Therobec, B-Plex, Formula B, Vitaplex, Tri-Vi-Sol, TL Gard, Vi-Daylin ADC, Nephrocaps QT, Virt-Vite, Lipotriad, Virt-Vite Forte, Stress-600, Cholinoid, Tri-Vita Drops, Liponol, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, Neuroforte-Six, MVI Pediatric, Nephrolan Rx, Zymacap, Dayalets, Sigtab, Therems, Allbee-C 800, Cefol, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Vi-Stress, Animal Shape Vitamins, B-50 Complex, Niva-Fol)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, EC-Naprosyn, Midol Extended Relief, Flanax Pain Reliever, Aflaxen, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Zydol, Tramahexal, Ryzolt, Tramal SR, ConZip, Larapam SR, GenRx Tramadol, Tramedo, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • wine
  • Xarelto (rivaroxaban)
  • Zoloft (sertraline)

Tylenol (acetaminophen) alcohol/food interactions

There is 1 alcohol/food interaction with Tylenol (acetaminophen)

Tylenol (acetaminophen) disease interactions

There are 3 disease interactions with Tylenol (acetaminophen) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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