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Tylenol (acetaminophen) Drug Interactions

A total of 181 drugs are known to interact with Tylenol (acetaminophen).

  • 14 major drug interactions
  • 73 moderate drug interactions
  • 94 minor drug interactions

Show all medications in the database that may interact with Tylenol (acetaminophen).

Check for interactions with Tylenol (acetaminophen)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Tylenol (acetaminophen)

  • Advil (ibuprofen)
  • albuterol (Ventolin, ProAir HFA, Ventolin HFA, Proventil, Proventil HFA, ProAir RespiClick, Respirol, AccuNeb, Vospire ER, Airet, Volmax, ProAir Digihaler)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Ecotrin Adult Low Strength, Bufferin, Aspiritab, Arthritis Pain, Fasprin, Halfprin, Easprin, Durlaza, Aspirtab, St. Joseph 81 mg Chewable Aspirin, Aspergum, Low Dose ASA, Buffered Aspirin, Ecotrin Maximum Strength, Ascriptin Enteric, Acuprin 81, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Aspirin Lite Coat, Bayer Aspirin Regimen, Aspi-Cor, Empirin, Bayer Children's Aspirin, Bufferin Extra Strength, St. Joseph Aspirin, Bayer Women's Aspirin With Calcium, Miniprin, Migralex, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Ecpirin, Zero-Order Release, YSP Aspirin, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Benadryl (diphenhydramine)
  • caffeine (Vivarin, NoDoz, Caffedrine, Stay Awake, Alert, Cafcit, Keep Going, Jet Alert Regular Strength, Jet Alert Double Strength, Jet Alert Maximum Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Diurex Ultra, Pep-Back Ultra, 357 HR Magnum, Enerjets, Fastlene, Molie, Overtime, Valentine)
  • codeine
  • diclofenac (Voltaren, Cataflam, Cambia, Zorvolex, Zipsor, Voltaren-XR, Dyloject)
  • Eliquis (apixaban)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Proprinal, Motrin IB, Children's Motrin, IBU-200, Advil Migraine, Ibu-8, Motrin Childrens, Nuprin, Motrin Migraine Pain, Ibuprofen PMR, NeoProfen, Caldolor, Advil Children's, Addaprin, Motrin Infant Drops, Advil Infant's Concentrated Drops, Rufen, Genpril, A-G Profen, Ibu-Tab, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, Childrens Ibuprofen Berry, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lasix (furosemide)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Levothyrox, Euthyrox, Levo-T, L Thyroxine Roche, Eutroxsig, Novothyrox, Oroxine, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metformin (Glucophage, Glucophage XR, Glumetza, Riomet, Fortamet)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • MiraLax (polyethylene glycol 3350)
  • Mucinex (guaifenesin)
  • multivitamin (Metanx, Daflon, Theragran, Folbic, Estroven, Nephro-Vite, Neurobion, Rena-Vite, Vitamins, Cerefolin, Foltx, Folbee, Nephrocaps, Foltanx, Cod Liver Oil, Multi Vitamin+, Cerefolin NAC, Thera, Vitamin B Complex 100, B Complex 100, PoDiaPN, Super B Complex, Lipoflavonoid, Cod Liver Oil Mint, Folic Acid XTRA, Rheumate, Daily Multiple Vitamins, Daily Vite, Nephplex Rx, Infuvite, One-A-Day 50+, Renal Caps, Tab-A-Vite, Essentiale, MVI Adult, Foltrate, Xyzbac, Berocca, Reno Caps, Chewable-Vite, Flintstones Multivitamins, Triphrocaps, Fletanol, Folinic-Plus, Nephro-Vite Rx, Poly-Vi-Sol, Lysiplex, Super B-50, B Complex 50, Nephronex, FaBB, Mebolic, TL Gard, StressTabs, B-Stress, Surbex with C, Surbex, Scotts Emulsion, Hylavite, Prostate 2.4, Rena-Vite Rx, Topfit Vitamin B Complex Forte, Vitamin A and D Concentrate, Folgard RX, Folplex, Vol-Care Rx, Foltanx RF, Virt-Caps, Therems, Childrens Chewable Multivitamins, Balanced B-50, Vitacirc-B, Essential Balance, Fruity Chew, Flintstones with C Multivitamins, Poly Vit Drops, Mynephron, Celebrate B-12, Apetigen, Stress Formula, Vitamin C, E, and Rose Hips, Mega B, L-methylfolate Ca, Me-Cbl NAC, Theragenerix, Cernevit, MTX Support, Cardiotek, Bugs Bunny Multiple Vitamins, Infuvite Pediatric, Vitamin A, D, Folastin, Levomefolate Calcium-Algal Powder, Folbee Plus, Folcaps, Abidec, Topfit Vitamin B Complex, Vitamin B Compound Strong, Jetepar, Centrum 8400, Folbalin, Foltabs 800, One-A-Day Men's Health Formula, Daily-Vite Men's Formula, Biotin Forte, B 100 Complex, B-Plex, Vitaplex, Tri-Vi-Sol, Metafolbic, Metafolbic Plus, Lipogen, Virt-Vite, Virt-Vite Forte, Stress-600, 1000 BC, Neurodep, Cefol, Protegra, Watkins Harvest, Balanced B-100, B-Scorbic, Bee with C, Nat-Rul B-125, Balanced B-150, Unicap Capsule, Unicap Jr, Unicap, Optilets-500, Super Plenamins, Vitamins for Hair, One-A-Day Essentials, Vi-Daylin Chewable, Folast, Enfolast, Sunkist Child Chewable with C, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Triphro, Poly-Vit Chew, Vita-Respa, Bugs Bunny with Extra C, Geravine, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Poly-Vi-Sol Drops, Baby Vitamin Drop, Vita Drop, MVC SDV, Glutofac, Allbee-C, Vitabee with C, Stress B with C, High Potency B+C, Av-VITE FB, Farbee with C, Renatabs, Tri-Vitamin, DEKAs Essential, Vitamin B-50, Folika-T, Vitamin B-100, D-400 international units, Vitamin B-100 T/R, Hexavitamin, Kenwood Therapeutic, Theravite, Thera-Plus, Oncovite, Glycogenics, Beminal-500, High Potency B Complex with B12 and C, Super B-100 TD, Tri-Vit Drops, Flintstones Toddler, One Tab Daily, Stress Formula 600, Tri-Vit, Apatate, T-Vites, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Beminal, Beminal with C Fortis, Full Spectrum B with C, Allbee with C, Prevital, Surbex Filmtab, Tender Age Vitamin ADC, Folgard Rx 2.2, Cernevit-12, SeroSyn, Diatx, Thex Forte, Metafolbic Plus RF, Dosoquin, Protegra Cardio, Virt-Vite Plus, K2 Plus D3, Vitamin Daily Liquid, Renaphro, Apetex, Virt-Gard, Dialyvite Rx, L-Methyl-MC, VP-Vite Rx, Vesselvite, Combgen, Unichem Multivitamin, L-Methyl-B6-B12, Health Aid Multivitamin, AllanTex, One Daily Multi-Essential, Larobec, Cardiotek Rx, Folbalin Plus, Dialyvite 800, Multi-Delyn, Multi Vits with Beta Carotene, Foleve Plus, Folnate, Folnate Plus, B-Complex with B-12, Foleve, Hair, Skin, & Nails Gummies, Folamin, DexFol, Equaline One Daily Essential, Menopause Relief with Lifenol, Av-VITE FB Forte, Folmor, Zycose, Vigomar Forte, Allbee Plus, Vimar, Triveen-CF, Nature's Bounty Hair Skin & Nails, Folbic RF, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Mebolex, Methazel, Dyzbac, Mynephrocaps, Nufola, Omega Q Plus, Acnepril, Super Theravite-M, Primaplex, Becomject-100, Poly-Vita Drops, MVI-12, B-Ject 100, L-Methyl-MC NAC, Therobec, Formula B, Vi-Daylin ADC, Nephrocaps QT, Lipotriad, Folplex 2.2, Cholinoid, Tri-Vita Drops, Thera-Tabs, Liponol, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, Neuroforte-Six, MVI Pediatric, B-Plex Plus, Nephrolan Rx, Ivites Rx, Zymacap, Vi-Daylin, Dayalets, Sigtab, Allbee-C 800, B-Complex SR, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Superplex-T, Vi-Stress, T-BMP, Animal Shape Vitamins, B-50 Complex, Niva-Fol)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Anaprox-DS, Naprelan, EC-Naprosyn, Flanax Pain Reliever, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • prednisone (Deltasone, Rayos, Sterapred, Sterapred DS, Prednicot, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Larapam SR, Tramedo, Ryzolt, GenRx Tramadol, ConZip, Zydol, Tramal SR, Tramahexal, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • wine
  • Xarelto (rivaroxaban)
  • Zoloft (sertraline)

Tylenol (acetaminophen) alcohol/food interactions

There is 1 alcohol/food interaction with Tylenol (acetaminophen)

Tylenol (acetaminophen) disease interactions

There are 3 disease interactions with Tylenol (acetaminophen) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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