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Tylenol (acetaminophen) Drug Interactions

A total of 179 drugs are known to interact with Tylenol (acetaminophen).

  • 14 major drug interactions
  • 71 moderate drug interactions
  • 94 minor drug interactions

Show all medications in the database that may interact with Tylenol (acetaminophen).

Check for interactions with Tylenol (acetaminophen)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Tylenol (acetaminophen)

  • Advil (ibuprofen)
  • albuterol (ProAir HFA, Ventolin, Ventolin HFA, Proventil, Proventil HFA, Respirol, ProAir RespiClick, AccuNeb, Airet, Volmax, Vospire ER)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Arthritis Pain, Fasprin, Ecotrin Adult Low Strength, Low Dose ASA, Bufferin, Aspiritab, Aspirin Lite Coat, Easprin, Bayer Children's Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Aspirtab, Halfprin, Aspergum, Durlaza, Acuprin 81, Miniprin, Bufferin Low Dose, Empirin, Buffered Aspirin, Entercote, St. Joseph Aspirin, Ascriptin Enteric, Ecpirin, Bayer Women's Aspirin With Calcium, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspi-Cor, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Ecotrin Maximum Strength, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Zero-Order Release, YSP Aspirin, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Benadryl (diphenhydramine)
  • caffeine (Vivarin, Alert, NoDoz, Cafcit, Keep Going, Jet Alert Regular Strength, Jet Alert Double Strength, Jet Alert Maximum Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Caffedrine, Keep Alert, Stay Awake, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Diurex Ultra, Pep-Back Ultra, 357 HR Magnum, Enerjets, Fastlene, Molie, Overtime, Valentine)
  • codeine
  • diclofenac (Voltaren, Cataflam, Cambia, Zorvolex, Zipsor, Voltaren-XR, Dyloject)
  • Eliquis (apixaban)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Advil Infant's Concentrated Drops, Children's Motrin, Advil Children's, Ibu-8, Ibuprofen PMR, Caldolor, Motrin Childrens, Motrin Migraine Pain, Addaprin, Ibu-4, Ibu-Tab, Rufen, Midol IB, A-G Profen, Childrens Ibuprofen Berry, Advil Migraine, Ibu-6, Motrin Infant Drops, NeoProfen, Genpril, Haltran, Menadol, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lasix (furosemide)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Levothyrox, Unithroid, Euthyrox, Levo-T, L Thyroxine Roche, Novothyrox, Levotabs, Oroxine, Eutroxsig, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metformin (Glucophage, Glumetza, Glucophage XR, Riomet, Fortamet)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • MiraLax (polyethylene glycol 3350)
  • Mucinex (guaifenesin)
  • multivitamin (Metanx, Daflon, Rena-Vite, Folbic, Theragran, Estroven, Nephro-Vite, Cerefolin, Neurobion, Folbee, Nephrocaps, Lipoflavonoid, Vitamins, B Complex 100, Vitamin B Complex 100, Foltx, Multi Vitamin+, Foltanx, Cod Liver Oil, Cod Liver Oil Mint, Super B Complex, Daily Multiple Vitamins, Folic Acid XTRA, Thera, PoDiaPN, Tab-A-Vite, Triphrocaps, Renal Caps, Infuvite, Rena-Vite Rx, Nephplex Rx, Chewable-Vite, Cerefolin NAC, Rheumate, Folinic-Plus, Foltrate, Folgard RX, Xyzbac, Berocca, Reno Caps, Flintstones Multivitamins, B Complex 50, Essentiale, Metafolbic Plus, Lipogen, Therems, Daily Vite, Lysiplex, Cernevit, Abidec, Topfit Vitamin B Complex, MVI Adult, Nephronex, Metafolbic, Nephro-Vite Rx, Virt-Vite, 1000 BC, Ivites Rx, Childrens Chewable Multivitamins, Oncovite, Apetigen, Super B-50, Theragenerix, MTX Support, Cardiotek, Topfit Vitamin B Complex Forte, Dialyvite 800, Biotin Forte, Vol-Care Rx, Folplex 2.2, StressTabs, Protegra, Super Plenamins, Essential Balance, Folast, Sunkist Child Chewable with C, Triphro, Geravine, Poly Vit Drops, Mynephron, Surbex, Vitamin B-100, Hexavitamin, One Tab Daily, Vitamin C, E, and Rose Hips, Scotts Emulsion, Mega B, Prostate 2.4, Full Spectrum B with C, Bugs Bunny Multiple Vitamins, Fletanol, Tender Age Vitamin ADC, Vitamin A, D, Vitamin Daily Liquid, L-Methyl-MC, Folbee Plus, Vitamin B Compound Strong, Jetepar, Centrum 8400, Folbalin, Multi Vits with Beta Carotene, Hair, Skin, & Nails Gummies, FaBB, One-A-Day Men's Health Formula, Daily-Vite Men's Formula, Folplex, Vimar, Nature's Bounty Hair Skin & Nails, Foltanx RF, Nufola, Omega Q Plus, Primaplex, Vitaplex, TL Gard, Liponol, Virt-Caps, Neurodep, Poly-Vi-Sol, B-Complex SR, Niva-Fol, Watkins Harvest, Balanced B-100, B-Stress, B-Scorbic, Bee with C, Balanced B-50, Nat-Rul B-125, Balanced B-150, Unicap Capsule, Unicap Jr, Vitacirc-B, Unicap, Optilets-500, Vitamins for Hair, One-A-Day Essentials, Vi-Daylin Chewable, Enfolast, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Fruity Chew, Poly-Vit Chew, Vita-Respa, Bugs Bunny with Extra C, Flintstones with C Multivitamins, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Poly-Vi-Sol Drops, Baby Vitamin Drop, Vita Drop, MVC SDV, Glutofac, Allbee-C, Vitabee with C, Stress B with C, High Potency B+C, Av-VITE FB, Farbee with C, Surbex with C, Renatabs, Tri-Vitamin, DEKAs Essential, Vitamin B-50, Folika-T, D-400 international units, Vitamin B-100 T/R, Celebrate B-12, Kenwood Therapeutic, Theravite, Thera-Plus, Glycogenics, Beminal-500, High Potency B Complex with B12 and C, Super B-100 TD, Tri-Vit Drops, Stress Formula, Flintstones Toddler, Stress Formula 600, Tri-Vit, Apatate, T-Vites, L-methylfolate Ca, Me-Cbl NAC, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Beminal, Beminal with C Fortis, Allbee with C, Prevital, Surbex Filmtab, Folgard Rx 2.2, Cernevit-12, SeroSyn, Infuvite Pediatric, Diatx, One-A-Day 50+, Thex Forte, Metafolbic Plus RF, Protegra Cardio, Virt-Vite Plus, Renaphro, Apetex, Virt-Gard, Dialyvite Rx, Folastin, Levomefolate Calcium-Algal Powder, Vesselvite, Folcaps, Combgen, Unichem Multivitamin, L-Methyl-B6-B12, Health Aid Multivitamin, AllanTex, Vitamin A and D Concentrate, One Daily Multi-Essential, Larobec, Cardiotek Rx, Folbalin Plus, Multi-Delyn, Foleve Plus, Foltabs 800, Folnate, Folnate Plus, B-Complex with B-12, Foleve, Folamin, DexFol, Equaline One Daily Essential, Menopause Relief with Lifenol, Av-VITE FB Forte, Folmor, Zycose, Vigomar Forte, Allbee Plus, Triveen-CF, B 100 Complex, Folbic RF, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Mebolex, Methazel, Mebolic, Dyzbac, Mynephrocaps, Acnepril, Super Theravite-M, Becomject-100, Poly-Vita Drops, MVI-12, B-Ject 100, L-Methyl-MC NAC, Therobec, B-Plex, Formula B, Tri-Vi-Sol, Vi-Daylin ADC, Nephrocaps QT, Lipotriad, Virt-Vite Forte, Stress-600, Cholinoid, Tri-Vita Drops, Thera-Tabs, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, Neuroforte-Six, MVI Pediatric, B-Plex Plus, Nephrolan Rx, Zymacap, Vi-Daylin, Dayalets, Sigtab, Allbee-C 800, Cefol, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Superplex-T, Vi-Stress, T-BMP, Animal Shape Vitamins, B-50 Complex)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, Flanax Pain Reliever, EC-Naprosyn, Leader Naproxen Sodium, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramedo, GenRx Tramadol, ConZip, Zydol, Ryzolt, Larapam SR, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Rybix, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • wine
  • Xarelto (rivaroxaban)
  • Zoloft (sertraline)

Tylenol (acetaminophen) alcohol/food Interactions

There is 1 alcohol/food interaction with Tylenol (acetaminophen)

Tylenol (acetaminophen) disease Interactions

There are 3 disease interactions with Tylenol (acetaminophen) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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