What is lasmiditan?
Lasmiditan is a type of drug called a ditan. It is an abortive migraine medication, which means it is used to help treat a migraine attack rather than prevent a migraine headache. Lasmiditan comes as a tablet.
In 2020, lasmiditan was the first ditan to be approved by the US Food and Drug Administration (FDA).
Lasmiditan works by blocking the pain pathways in the brain. It is a serotonin (5-HT)1F receptor agonist, but its exact mechanism of action is unknown.
Unlike triptans, which are the gold-standard of treatment for migraines, lasmiditan does not constrict blood vessels in the heart and brain.
What is lasmiditan used for?
Lasmiditan is a prescription medicine used for the acute treatment of migraine attacks with or without aura in adults.
- Lasmiditan is not used as a preventive treatment of migraine.
- It is not known if lasmiditan is safe and effective in children.
- Lasmiditan is a federally controlled substance (CV) because it contains lasmiditan that can be abused. Keep lasmiditan in a safe place to protect it from theft. Never give your lasmiditan to anyone else, because it may harm them. Selling or giving away lasmiditan is against the law. Tell your healthcare provider if you have ever abused or been dependent on alcohol, prescription medicines or street drugs.
- Do not drive or operate machinery for at least 8 hours after you take lasmiditan, even if you feel well enough.
- You should not take lasmiditan if you cannot wait at least 8 hours between taking lasmiditan and driving or operating machinery.
What should I tell my doctor before taking lasmiditan?
Before you take lasmiditan, tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems
- have high blood pressure
- have a low heart rate
- are allergic to lasmiditan
How should I take lasmiditan?
- Take lasmiditan exactly as your healthcare provider tells you to take it.
- Your healthcare provider may change your dose. Do not change your dose without first talking to your healthcare provider.
- Take lasmiditan tablets by mouth with or without food.
- Swallow lasmiditan tablets whole. Do not split, crush, or chew.
- Do not take more than one dose in a 24-hour period.
- If you take lasmiditan 50 mg, 100 mg, or 200 mg, and your headache goes away but comes back, you should not take a second dose within 24 hours.
- Some people who take too many lasmiditan tablets may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with lasmiditan.
- You should write down when you have headaches and when you take lasmiditan so you can talk to your healthcare provider about how lasmiditan is working for you.
What should I avoid while taking lasmiditan?
Do not drive or operate machinery for at least 8 hours after taking lasmiditan.
You should not drink alcohol or take other medicines that make you drowsy while taking lasmiditan.
- The recommended dose of lasmiditan is 50 mg, 100 mg, or 200 mg taken orally, as needed.
- No more than one dose should be taken in 24 hours.
- Administer tablets whole.
What are the side effects of lasmiditan?
Lasmiditan can cause serious side effects including:
- See “Important information”
- serotonin syndrome. Serotonin syndrome is a rare but serious problem that can happen in people using lasmiditan, especially if lasmiditan is used with anti-depressant medicines called SSRIs or SNRIs. Call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome:
- mental changes such as seeing things that are not there (hallucinations), agitation, or coma
- fast heartbeat
- changes in blood pressure
- high body temperature
- tight muscles
- trouble walking
- nausea, vomiting, or diarrhea
- medication overuse headache. Some people who take medicines like lasmiditan for the acute treatment of migraine attacks for 10 or more days each month may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with lasmiditan.
The most common side effects of lasmiditan include:
- feeling tired
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of lasmiditan. For more information ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Lilly at 1-800-LillyRx (1-800-545-5979).
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Your healthcare provider will decide if you can take lasmiditan with your other medicines.
Especially, tell your healthcare provider if you take:
- propranolol or other medicines that can lower your heart rate
- any medicines that can increase your blood pressure
- any medicines that make you sleepy
- anti-depressant medicines called:
- selective serotonin reuptake inhibitors (SSRIs)
- serotonin norepinephrine reuptake inhibitors (SNRIs)
- tricyclic anti-depressants (TCAs)
- monoamine oxidase inhibitors (MAOIs)
Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
Know the medicines you take. Keep a list of them and show it to your healthcare provider or pharmacist when you get a new medicine.
Pregnancy and breastfeeding
Tell your doctor if your are pregnant or plan to become pregnant. It is not known if lasmiditan will harm your unborn baby.
There is a pregnancy registry for women who take lasmiditan. The purpose of this registry is to collect information about the health of you and your baby. To learn more call 1-833-464-4724 or visit www.migrainepregnancyregistry.com. You may also talk to your healthcare provider about how you can take part in this registry.
Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if lasmiditan passes into your breastmilk.
- Store lasmiditan at room temperature between 68°F to 77°F (20°C to 25°C).
- Keep lasmiditan and all medicines out of the reach of children.
What are the ingredients in lasmiditan?
Active ingredient: lasmiditan hemisuccinate
Inactive ingredients: croscarmellose sodium, magnesium stearate, microcrystalline cellulose, pregelatinized starch, sodium lauryl sulfate.
Color mixture ingredients: black ferric oxide, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide. 100 mg tablets also contain red ferric oxide.
Lasmiditan is marketed under the brandname Reyvow by Lilly USA, LLC, Indianapolis, IN 46285, USA
Frequently asked questions
More about lasmiditan
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- Side effects
- Dosage information
- During pregnancy
- Drug class: antimigraine agents
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.