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Lasmiditan Dosage

Medically reviewed by Drugs.com. Last updated on Aug 5, 2020.

Applies to the following strengths: 50 mg; 100 mg

Usual Adult Dose for Migraine

Initial dose: 50 mg, 100 mg, or 200 mg orally once
Maximum dose: 1 dose per day

Comments:
-This drug should not be taken unless the patient can wait 8 hours or more before driving or operating machinery.
-No more than 1 dose should be taken in 24 hours; a second dose has not been shown to be effective for the same migraine attack.
-The safety of treating an average of more than 4 migraine attacks in a 30-day period has not been established.
-This drug is not indicated for the prevention of migraine attacks.

Use: For the acute treatment of migraine with or without aura.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended
Severe hepatic impairment: Not recommended

Dose Adjustments

Elderly: Dose selection should be cautious, generally starting at the low end of the dosing range

Precautions

CONTRAINDICATIONS:
-None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

There is a pending decision for drug scheduling in review by the Drug Enforcement Administration

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally with or without food
-No more than 1 dose should be taken in 24 hours; the safety of treating an average of more than 4 migraine attacks in a 30-day period has not been established
-Patients should wait at least 8 hours after dosing before driving or operating machinery

General:
-In a human abuse potential study, this drug showed statistically significantly higher "drug liking" scores than placebo and statistically significantly lower scores compared to alprazolam 2 mg; euphoric mood occurred to a similar extent with lasmiditan doses of 200 mg and 400 mg and alprazolam 2 mg (43% to 49%).
-Concomitant use with other CNS depressant drugs has not been evaluated in clinical studies.
-Patients should understand that they may not be able to assess their own driving competence and the degree of impairment caused by this drug; if they are unable to wait 8 hours or more before driving a motor vehicle or operating machinery, they should not take this medication.

Monitoring:
-Monitor for risk of drug abuse and signs of misuse or abuse
-Monitor heart rate in patients for whom changes in heart rate may be problematic
-Monitor blood pressure in patients for whom increased blood pressure not be tolerated

Patient advice:
-Patients should be instructed to read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
-Patients should be instructed to avoid driving or operating machinery for at least 8 hours after taking a dose; if they are not able to wait the necessary time, they should not take a dose.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.