Eptinezumab Side Effects
Medically reviewed by Drugs.com. Last updated on Mar 25, 2025.
Applies to eptinezumab: intravenous solution.
Precautions
It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.
This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have chest tightness, cough, rash, itching, redness of the face, trouble breathing or swallowing, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, or unusual tiredness or weakness while you are receiving this medicine.
Tell your doctor right away if you are pregnant or planning to become pregnant before receiving this medicine.
Common side effects of eptinezumab
Some side effects of eptinezumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- headache
- muscle aches
- sore throat
- stuffy or runny nose
Incidence not known
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Serious side effects of eptinezumab
Along with its needed effects, eptinezumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking eptinezumab:
Less common side effects
- chest tightness
- fast heartbeat
- feeling of warmth
- fever
- hives, itching, skin rash
- hoarseness
- irritation
- joint pain, stiffness or swelling
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
- redness of the skin
- redness of the face, neck, arms and occasionally, upper chest
- swelling of the eyelids, face, lips, hands, or feet
- trouble breathing or swallowing
Incidence not known
- cough
- dizziness
- unusual tiredness or weakness
For healthcare professionals
Applies to eptinezumab: intravenous solution.
General adverse events
The most commonly reported adverse reactions were nasopharyngitis and hypersensitivity.[Ref]
Hypersensitivity
- Common (1% to 10%): Hypersensitivity (including angioedema, urticaria, flushing, rash
- Postmarketing reports: Anaphylactic reactions (including hypotension and respiratory difficulties)
and pruritus)
Immunologic
- Very common (10% or more): Anti-drug antibodies (up to 20.6%)
Local
- Uncommon (less than 2%): Infusion-site reactions including extravasation
Other
- Common (1% to 10%): Fatigue
Respiratory
- Common (1% to 10%): Nasopharyngitis
- Frequency not reported (infusion-related respiratory symptoms): Nasal congestion, rhinorrhea, throat irritation, cough, sneezing, dyspnea
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References
1. (2022) "Product Information. Vyepti (eptinezumab)." Lundbeck Inc
2. (2022) "Product Information. Vyepti (eptinezumab)." Lundbeck Ltd
Frequently asked questions
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Further information
Eptinezumab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
