Aleve Interactions
There are 458 drugs known to interact with Aleve (naproxen), along with 11 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 99 are major, 341 are moderate, and 18 are minor.
- View all 458 medications that may interact with Aleve
- View Aleve alcohol/food interactions (4)
- View Aleve disease interactions (11)
Most frequently checked interactions
View interaction reports for Aleve (naproxen) and the medicines listed below.
- aspirin
- aspirin
- atorvastatin
- atorvastatin
- gabapentin
- gabapentin
- ibuprofen
- ibuprofen
- levothyroxine
- levothyroxine
- lisinopril
- lisinopril
- melatonin
- melatonin
- metformin
- metformin
- omeprazole
- omeprazole
- prednisone
- prednisone
- tramadol
- tramadol
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
- Zyrtec (cetirizine)
Aleve alcohol/food interactions
There are 4 alcohol/food interactions with Aleve (naproxen).
Aleve disease interactions
There are 11 disease interactions with Aleve (naproxen) which include:
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- sodium
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
Report options
More about Aleve (naproxen)
- Aleve consumer information
- Compare alternatives
- Reviews (154)
- Drug images
- Latest FDA alerts (8)
- Side effects
- Dosage information
- During pregnancy
- Support group
- Drug class: Nonsteroidal anti-inflammatory drugs
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Cyclobenzaprine
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Meloxicam
Meloxicam is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Aspirin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about ...
Ibuprofen
Ibuprofen (Advil, Motrin) treats minor aches and pains caused by the common cold, headaches ...
Prednisone
Prednisone is used to treat allergic disorders, ulcerative colitis, psoriasis and arthritis. Learn ...
Acetaminophen
Acetaminophen is a widely used pain reliever and fever reducer for conditions like headaches ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
