Aleve Interactions
There are 459 drugs known to interact with Aleve (naproxen), along with 11 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 99 are major, 342 are moderate, and 18 are minor.
- View all 459 medications that may interact with Aleve
- View Aleve alcohol/food interactions (4)
- View Aleve disease interactions (11)
Most frequently checked interactions
View interaction reports for Aleve (naproxen) and the medicines listed below.
- aspirin
- aspirin
- atorvastatin
- atorvastatin
- gabapentin
- gabapentin
- ibuprofen
- ibuprofen
- levothyroxine
- levothyroxine
- lisinopril
- lisinopril
- melatonin
- melatonin
- metformin
- metformin
- omeprazole
- omeprazole
- prednisone
- prednisone
- tramadol
- tramadol
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
- Zyrtec (cetirizine)
Aleve alcohol/food interactions
There are 4 alcohol/food interactions with Aleve (naproxen).
Aleve disease interactions
There are 11 disease interactions with Aleve (naproxen) which include:
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- sodium
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
Report options
More about Aleve (naproxen)
- Aleve consumer information
- Compare alternatives
- Reviews (154)
- Drug images
- Latest FDA alerts (8)
- Side effects
- Dosage information
- During pregnancy
- Support group
- Drug class: Nonsteroidal anti-inflammatory drugs
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
