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Advil (ibuprofen) Drug Interactions

A total of 479 drugs are known to interact with Advil (ibuprofen).

  • 125 major drug interactions
  • 325 moderate drug interactions
  • 29 minor drug interactions

Show all medications in the database that may interact with Advil (ibuprofen).

Check for interactions

Type in a drug name to check for interactions with Advil (ibuprofen).

Most frequently checked interactions

View interaction reports for Advil (ibuprofen) and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • Aleve (naproxen)
  • aspirin (Ecotrin, Acetylsalicylic Acid, Aspir 81, Bayer Aspirin, Aspirin Low Strength, Bufferin, Arthritis Pain, Easprin, Ascriptin, Fasprin, Low Dose ASA, Buffered Aspirin, Aspir-Low, Durlaza, Ascriptin Enteric, Acuprin 81, Halfprin, Aspergum, Empirin, Bayer Children's Aspirin, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Entercote, Minitabs, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Aspiritab, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Benadryl (diphenhydramine)
  • caffeine (Vivarin, Caffedrine, Diurex Ultra, 357 HR Magnum, Overtime, Valentine, NoDoz, Jet Alert Regular Strength, Jet Alert Double Strength, Jet Alert Maximum Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Stay Awake, Verv, Alert, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, Cafcit, Enerjets, Fastlene, Keep Going, Molie)
  • codeine
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Eltroxin, Levothroid, Levothyrox, Euthyrox, Unithroid, Levo-T, Oroxine, L Thyroxine Roche, Eutroxsig, Novothyrox, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • melatonin (Melatonin Time Release, SGard, Bio-Melatonin, Health Aid Melatonin, VesPro Melatonin)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metformin (Glucophage, Glumetza, Fortamet, Glucophage XR, Riomet)
  • Mucinex (guaifenesin)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • Percocet (acetaminophen / oxycodone)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Liquid Pred, Meticorten, Orasone, Prednicen-M)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramahexal, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol, Zamadol, Zydol XL, Rybix ODT, Ultram ODT)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Advil (ibuprofen) alcohol/food interactions

There are 3 alcohol/food interactions with Advil (ibuprofen)

Advil (ibuprofen) disease interactions

There are 13 disease interactions with Advil (ibuprofen) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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