Medications for Cluster Headaches
See also: sub-topics
Drugs used to treat Cluster Headaches
The following list of medications are in some way related to or used in the treatment of this condition.
Drug name | Rating | Reviews | Activity ? | Rx/OTC | Pregnancy | CSA | Alcohol |
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tizanidine Off-label | 6.9 | 30 reviews | Rx | ||||
Generic name: tizanidine systemic Brand name: Zanaflex Drug class: skeletal muscle relaxants For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information Off-label: Yes |
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sumatriptan | 8.4 | 80 reviews | Rx | ||||
Generic name: sumatriptan systemic Brand names: Imitrex, Imitrex Statdose Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information |
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verapamil | 8.9 | 62 reviews | Rx | ||||
Generic name: verapamil systemic Brand names: Calan SR, Verelan PM, Verelan Drug class: calcium channel blocking agents, group IV antiarrhythmics For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information |
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Zanaflex Off-label | 8.0 | 7 reviews | Rx | ||||
Generic name: tizanidine systemic Drug class: skeletal muscle relaxants For consumers: dosage, interactions, side effects For professionals: Prescribing Information Off-label: Yes |
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Imitrex | 8.8 | 28 reviews | Rx | ||||
Generic name: sumatriptan systemic Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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indomethacin | 8.5 | 17 reviews | Rx | ||||
Generic name: indomethacin systemic Brand names: Indocin, Indocin SR Drug class: Nonsteroidal anti-inflammatory drugs For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information |
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prednisone | 9.0 | 21 reviews | Rx | ||||
Generic name: prednisone systemic Drug class: glucocorticoids For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information |
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Migranal | 9.3 | 3 reviews | Rx | ||||
Generic name: dihydroergotamine systemic Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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Cafergot | 9.0 | 6 reviews | Rx | ||||
Generic name: caffeine / ergotamine systemic Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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Calan SR | 10 | 2 reviews | Rx | ||||
Generic name: verapamil systemic Drug class: calcium channel blocking agents, group IV antiarrhythmics For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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cyproheptadine | 9.8 | 4 reviews | Rx | ||||
Generic name: cyproheptadine systemic Drug class: antihistamines For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information |
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Emgality | 5.8 | 31 reviews | Rx | ||||
Generic name: galcanezumab systemic Drug class: CGRP inhibitors For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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dihydroergotamine | 8.8 | 8 reviews | Rx | ||||
Generic name: dihydroergotamine systemic Brand names: Migranal, D.H.E. 45 Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information |
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caffeine / ergotamine | 9.1 | 10 reviews | Rx | ||||
Generic name: caffeine / ergotamine systemic Brand names: Cafergot, Migergot Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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Imitrex Statdose | 9.7 | 3 reviews | Rx | ||||
Generic name: sumatriptan systemic Drug class: antimigraine agents For consumers: dosage, interactions, side effects |
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Indocin | 9.0 | 1 review | Rx | ||||
Generic name: indomethacin systemic Drug class: Nonsteroidal anti-inflammatory drugs For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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zolmitriptan Off-label | 9.3 | 3 reviews | Rx | ||||
Generic name: zolmitriptan systemic Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information Off-label: Yes |
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lithium Off-label | 8.8 | 8 reviews | Rx | ||||
Generic name: lithium systemic Drug class: antimanic agents For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information Off-label: Yes |
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Verelan PM | 10 | 1 review | Rx | ||||
Generic name: verapamil systemic Drug class: calcium channel blocking agents, group IV antiarrhythmics For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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Verelan | 8.0 | 1 review | Rx | ||||
Generic name: verapamil systemic Drug class: calcium channel blocking agents, group IV antiarrhythmics For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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D.H.E. 45 | 9.0 | 3 reviews | Rx | ||||
Generic name: dihydroergotamine systemic Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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Indocin SR | Rate | Add review | Rx | ||||
Generic name: indomethacin systemic Drug class: Nonsteroidal anti-inflammatory drugs For consumers: dosage, interactions, side effects |
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galcanezumab | 5.8 | 33 reviews | Rx | ||||
Generic name: galcanezumab systemic Brand name: Emgality Drug class: CGRP inhibitors For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph |
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Migergot | 0.0 | 1 review | Rx | ||||
Generic name: caffeine / ergotamine systemic Drug class: antimigraine agents For consumers: dosage, interactions, side effects For professionals: Prescribing Information |
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Frequently asked questions
- Prednisone: What are 12 Things You Should Know?
- What are the new drugs for the treatment of migraines?
- Emgality vs Aimovig - how do they compare?
- Does injecting Emgality cause a reaction?
- What are the brands of sumatriptan?
Topics under Cluster Headaches
- Cluster-Tic Syndrome (6 drugs)
Learn more about Cluster Headaches
Care guides
Symptoms and treatments
Medicine.com guides (external)
Legend
Rating | For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). |
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Activity | Activity is based on recent site visitor activity relative to other medications in the list. |
Rx | Prescription only. |
OTC | Over-the-counter. |
Rx/OTC | Prescription or Over-the-counter. |
Off-label | This medication may not be approved by the FDA for the treatment of this condition. |
EUA | An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. |
Expanded Access | Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. |
Pregnancy Category | |
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A | Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). |
B | Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. |
C | Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |
D | There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |
X | Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. |
N | FDA has not classified the drug. |
Controlled Substances Act (CSA) Schedule | |
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M | The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. |
U | CSA Schedule is unknown. |
N | Is not subject to the Controlled Substances Act. |
1 | Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. |
2 | Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
3 | Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
4 | Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
5 | Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |
Alcohol | |
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X | Interacts with Alcohol. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.