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Medications for Cluster Headaches

About Cluster Headaches:  A term used to describe a headache that is typified by constant, unilateral pain around the eye, with onset usually within 2-3 hours of falling asleep. Can be accompanied by a blocked nasal passage, runny nose, and-or tearing.

Drugs Used to Treat Cluster Headaches

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
tizanidine Off Label C N X 22 reviews
7.1

Generic name: tizanidine systemic

Brand name:  Zanaflex

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

sumatriptan C N 66 reviews
8.3

Generic name: sumatriptan systemic

Brand names:  Imitrex, Imitrex Statdose

Drug class: antimigraine agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

verapamil C N X 53 reviews
9.1

Generic name: verapamil systemic

Brand names:  Calan SR, Calan, Verelan, Verelan PM, Isoptin SR …show all

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Zanaflex Off Label C N X 6 reviews
7.8

Generic name: tizanidine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

Imitrex C N 23 reviews
8.5

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

indomethacin C N X 10 reviews
7.9

Generic name: indomethacin systemic

Brand names:  Indocin, Indocin SR

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

prednisone C N 12 reviews
9.4

Generic name: prednisone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Cafergot X N 6 reviews
9.0

Generic name: caffeine / ergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Migranal X N 3 reviews
9.3

Generic name: dihydroergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Calan SR C N X 1 review
10

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

dihydroergotamine X N 6 reviews
9.2

Generic name: dihydroergotamine systemic

Brand names:  Migranal, D.H.E. 45

Drug class: antimigraine agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

caffeine / ergotamine X N 7 reviews
9.0

Generic name: caffeine / ergotamine systemic

Brand names:  Cafergot, Migergot

Drug class: antimigraine agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Imitrex Statdose C N 3 reviews
9.4

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

Indocin C N X 1 review
7.3

Generic name: indomethacin systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Calan C N X 2 reviews
9.3

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

cyproheptadine B N X 3 reviews
9.7

Generic name: cyproheptadine systemic

Drug class: antihistamines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

lithium Off Label D N X 8 reviews
8.8

Generic name: lithium systemic

Drug class: antimanic agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

zolmitriptan Off Label C N X 3 reviews
9.3

Generic name: zolmitriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Verelan C N X 1 review
8.0

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Verelan PM C N X 1 review
10

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Indocin SR C N X Add review
8.0

Generic name: indomethacin systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Isoptin SR C N X 1 review
10

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

D.H.E. 45 X N 3 reviews
9.0

Generic name: dihydroergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Migergot X N 1 review
0.0

Generic name: caffeine / ergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Emgality N 1 review
8.0

Generic name: galcanezumab systemic

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Topics under Cluster Headaches

Learn more about Cluster Headaches

Symptoms and treatments

ICD-10 CM Clinical Codes (External)

Legend

Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Off Label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

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