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Medications for Cluster Headaches

What is Cluster Headaches: A term used to describe a headache that is typified by constant, unilateral pain around the eye, with onset usually within 2-3 hours of falling asleep. Can be accompanied by a blocked nasal passage, runny nose, and-or tearing.

Compare drugs associated with Cluster Headaches

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Zanaflex Off Label Rx C N X 5 reviews
7.0

Generic name: tizanidine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
tizanidine Off Label Rx C N X 15 reviews
6.0

Generic name: tizanidine systemic

Brand name:  Zanaflex

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
sumatriptan Rx C N 57 reviews
8.0

Generic name: sumatriptan systemic

Brand names:  Imitrex, Sumavel DosePro, Imitrex Statdose, Imitrex Nasal, Alsuma

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Imitrex Rx C N 22 reviews
8.0

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
verapamil Rx C N X 46 reviews
9.0

Generic name: verapamil systemic

Brand names:  Calan SR, Calan, Verelan, Verelan PM, Covera-HS, Isoptin SR

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
indomethacin Rx C N X 7 reviews
7.0

Generic name: indomethacin systemic

Brand names:  Indocin, Indocin SR, Indocin IV

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Cafergot Rx X N 5 reviews
8.0

Generic name: caffeine / ergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Migranal Rx X N 2 reviews
9.0

Generic name: dihydroergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Calan SR Rx C N X 1 review
10

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
prednisone Rx C N 5 reviews
9.0

Generic name: prednisone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Sumavel DosePro Rx C N 4 reviews
7.0

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Indocin Rx C N X Add review
6.0

Generic name: indomethacin systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Calan Rx C N X 2 reviews
9.0

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Imitrex Statdose Rx C N 3 reviews
9.0

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

 
caffeine / ergotamine Rx X N 6 reviews
8.0

Generic name: caffeine / ergotamine systemic

Brand names:  Cafergot, Migergot

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
dihydroergotamine Rx X N 5 reviews
9.0

Generic name: dihydroergotamine systemic

Brand names:  Migranal, D.H.E. 45

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Imitrex Nasal Rx C N 3 reviews
9.0

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

 
cyproheptadine Rx B N X 3 reviews
9.0

Generic name: cyproheptadine systemic

Drug class: antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Alsuma Rx C N Add review Add

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Indocin SR Rx C N X Add review
8.0

Generic name: indomethacin systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Verelan Rx C N X 1 review
8.0

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Verelan PM Rx C N X 1 review
10

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
lithium Off Label Rx D N X 6 reviews
8.0

Generic name: lithium systemic

Drug class: miscellaneous antipsychotic agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Covera-HS Rx C N X Add review Add

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Isoptin SR Rx C N X 1 review
10

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
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Topics under Cluster Headaches

Learn more about Cluster Headaches

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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