Brekiya Dosage

Generic name: DIHYDROERGOTAMINE MESYLATE 1mg in 1mL
Dosage form: injection
Drug class: Antimigraine agents

Medically reviewed by Drugs.com. Last updated on May 15, 2025.

Recommended Dosage

BREKIYA autoinjector is for subcutaneous injection only.

The recommended dose of BREKIYA is 1 mg administered subcutaneously via a single 1 mL autoinjector. The dose may be repeated, as needed, at 1-hour intervals to a total maximum of 3 mg (3 doses) in a 24-hour period.

Do not exceed 6 mg (6 doses) total in a week.

Assessment Prior to First Dose

Prior to initiation of BREKIYA, a cardiovascular evaluation is recommended. For patients with risk factors predictive of coronary artery disease who are determined to have a satisfactory cardiovascular evaluation, it is strongly recommended that administration of the first dose of BREKIYA take place in the setting of an equipped healthcare facility.

Important Administration Instructions

See the “Instructions for Use” for detailed steps for administering the subcutaneous injection using the autoinjector.

Preparation

BREKIYA is a prefilled, single-dose disposable autoinjector intended to be given subcutaneously into the skin of the middle thigh.
Rotate injection sites. Choose an injection site at least 2 inches away from the last injection site.
Do not inject into moles, scars, birthmarks, or areas where the skin is tender, bruised, red, or hard.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Carefully examine the liquid medication for discoloration, cloudiness, floating flakes or particles. Administer only if clear and colorless.
Administration
Remove the red needle cap by pulling it straight off.
Position the autoinjector straight onto the cleaned injection site with the white safety guard resting on the skin. Push the autoinjector down and press and release the gray activation button to start the injection. A “click” will sound when the injection starts.
The autoinjector takes approximately 10 seconds to deliver the dose; when the viewing window is fully blocked (completely blue), the full dose has been administered.