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Tizanidine Dosage

Medically reviewed by Last updated on Feb 27, 2023.

Applies to the following strengths: 4 mg; 2 mg; 6 mg

Usual Adult Dose for Muscle Spasm

Initial dose: 2 mg orally every 6 to 8 hours as needed

Maximum single dose: 16 mg
Maximum daily dose: 36 mg in 24 hours


Use: Management of spasticity.

Renal Dose Adjustments

Severe renal impairment (CrCl less than 25 mL/min): Individualize therapy with lower doses during dose titration; if higher doses are required, individual doses should be increased rather increasing the dosing frequency; closely monitor for toxicity

Liver Dose Adjustments

Not recommended

Dose Adjustments

Use with caution in elderly patients, especially those with renal impairment.

Drug withdrawal:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:



Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.