Tizanidine Side Effects
Medically reviewed by Drugs.com. Last updated on Aug 15, 2023.
Commonly reported side effects of tizanidine include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, and xerostomia. Other side effects include: constipation, and increased liver enzymes. Continue reading for a comprehensive list of adverse effects.
Applies to tizanidine: oral capsules and tablets.
Side effects include:
For Healthcare Professionals
Applies to tizanidine: oral capsule, oral tablet.
The most frequently reported adverse reactions include dry mouth, somnolence/sedation, asthenia, and dizziness.[Ref]
Very common (10% or more): Somnolence (up to 48%), dizziness (up to 16%)
Common (1% to 10%): Speech disorder, dyskinesia
Frequency not reported: Headache, ataxia, dysarthria
Postmarketing reports: Convulsion, paresthesia, tremor[Ref]
Very common (10% or more): Dry mouth (up to 49%)
Rare (0.01% to 0.1%): Nausea, gastrointestinal disorder
Frequency not reported: Abdominal pain, loss of appetite[Ref]
Common (1% to 10%): Liver test abnormality
Very rare (less than 0.01%): Hepatic failure
Frequency not reported: Hepatotoxicity
Postmarketing reports: Hepatitis[Ref]
Common (1% to 10%): Amblyopia
Frequency not reported: Accommodation disorder[Ref]
Frequency not reported: Pruritus
Common (1% to 10%): Fatigue
Frequency not reported: Drug withdrawal reactions including rebound hypertension, tachycardia, and hypertonia[Ref]
Frequency not reported: Anaphylaxis, hypersensitivity reactions
Rare (0.01% to 0.1%): Muscular weakness
Postmarketing reports: Arthralgia[Ref]
Common (1% to 10%): Nervousness
Frequency not reported: Confusional state
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Related treatment guides
1. Product Information. Zanaflex (tizanidine). Acorda Therapeutics. 2001.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.