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User Reviews for Sumatriptan to treat Cluster Headaches

Also known as: Imitrex, Tosymra, Imitrex Statdose, Zembrace SymTouch, Onzetra Xsail Imitrex Nasal

Sumatriptan has an average rating of 8.4 out of 10 from a total of 71 ratings for the treatment of Cluster Headaches. 85% of reviewers reported a positive effect, while 13% reported a negative effect.

Sumatriptan Rating Summary

8.4/10 average rating

71 ratings from 74 user reviews.

Compare all 30 medications used in the treatment of Cluster Headaches.

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Reviews for Sumatriptan

John ( Cluster Sufferer 35 yrs ) July 2, 2014

Imitrex (sumatriptan): “Imitrex in any form is the Best med for Cluster headaches by far. High flow oxygen at first twinge, and the pill at the onset (even if you think it might hurt) Most effective. You all know how fast they come on. Usually work immediately unless late in a cycle. I too wish you could take more than twice in a 24 hr period. After suffering for almost 20 yrs with no medicine at All. For these crippling things. I have tried all Imitrex types, injections ,pills, nasal sprays. Injections are fast but so very expensive and painful as well. Nasal spray is nauseating for me, the pill form has always worked well if taken at the very BLINK of headache. Because of price and insurance restrictions I would wait to take the medicine. Not anymore.”

9 / 10
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Mike · Taken for 1 to 2 years October 13, 2019

“I've had cluster headaches for about 10 years. Brutal, soul crushing headaches maybe 100 to 200 times more painful than a common tension headache. Read about Sumatran and asked my doctor. He prescribed it about 2 years ago. It's been a miracle for me. Completely gets rid of the headache within 15 to 20 minutes. No side effects of any kind. To those who have experienced side effects I might suggest taking a half or even a quarter dose. I was prescribed 20 mg and I usually cut them in half and 10 mg works great for me. If 10 mg is an effective dose, at least for some people as I can attest, then I can only imagine what taking 10 times the dose for your body or system might do, as I'm reading some people here were prescribed 50 or even 100 mg. Hope this helps.”

10 / 10
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ClusterScrewed June 30, 2016

Imitrex (sumatriptan): “Words cannot express how grateful I am for this medicine. I have dealt with these crippling headaches since my mid 20's. Now in my mid-30's, I finally happened upon a physician (at a CareNow of all places) who actually listened to me as I told him of the nightmare I face at least three times a day, every day, for months on end, and prescribed Imitrex for me. If taken at the very first sign of an attack, these little beauties (I take the oral) can save you 30 minutes to several hours of unimaginable pain. I cannot recommend enough that my fellow cluster headache sufferers ask their doctor about considering Imitrex. While there's no cure, this is the closest thing I've found so far that at least makes living with these headaches bearable”

9 / 10
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June moon May 23, 2014

Imitrex (sumatriptan): “Imitrex works very well for my eyeball pain, light and odour, toxic smells, nasal stuffiness that leads to migraines. Migraines. I am sensitive to gluten of all kinds, if I ingest some, I WILL get nasal stuffiness that will lead to a migraine or cluster headaches. Imitrex works in 45 mins, sometimes sleep is needed to take it away. Sometimes I get migraines for a week or so. Sometimes I take it as a last resort, after trying allergy meds, Tylenol or Valium. But Imitrex works for me. I eat very healthy, no breads of any kind, no gluten, very little sugar. I read all labels, eat mostly veges and meat, mostly organic, I'm getting better at that. ”

10 / 10
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Debbie42 December 4, 2013

Imitrex (sumatriptan): “This is a miracle for me. Cluster headaches would put me out of commission for 2 days. Imitrex gets rid of the intense pain of my eye feeling like it might pop out of my head! The first few times I took it I had side effects of the heavy feeling on my chest and in my muscles after 3x I can take with no side effects. I've only taken it 5x but still working great.”

9 / 10
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BeeeDeee August 12, 2019

“I go to a headache clinic to deal with my intense cluster/migraine headache bouts. My doctor asked me to try sumatriptan as an option for dealing with the worst headaches as soon as I feel them come on. I liked the idea of having something to take only during headache periods, as opposed to daily. I had the opportunity to give it a shot this weekend and... woah. Sumatriptan does NOT agree with my system. Shortly after taking it, my scalp at the crown of my head felt like it was on fire. So painful. The back of my neck also seized up and I had to lie down, even though it was impossible to get comfortable. The good thing is that this medication has a short half-life (two hours), so my discomfort, though intense, was short-lived. Did my headache fade away? Absolutely, but the discomfort it was swapped out for was arguably worse and so scary. I'm returning the remainder of this prescription to the pharmacy for disposal.”

1 / 10
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Anonymous · Taken for 10 years or more June 23, 2012

Imitrex (sumatriptan): “I suffered with cluster headaches for about 15 years before finally receiving an Imitrex injection in the hospital ER. My headache was gone within 5-10 minutes, I thought it was a miracle. I do not leave home without it!”

10 / 10
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Frequently asked questions

Lynn Rose Miles June 22, 2014

Imitrex (sumatriptan): “I have been using Imitrex since it first came out in the 90's. It was a God send. I've had migraines for 42 years. I get about six migraines a month. Imitrex always works BUT for me I pay a price with stomach aches. Sometimes I refrain from taking Imitrex for fear of the stomach pains.”

9 / 10
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Chefcasey74 · Taken for 5 to 10 years July 23, 2020

Imitrex (sumatriptan): “I use Imitrex to treat my cluster headaches I have episodic clusters. Usually get them once a year for a month or more. I get two to three attacks a day during the cycle. I use Imitrex injections and pills, the injections get rid of the pain in about 10 minutes and the Imitrex pills take about about thirty minutes to work . Don’t know what I would do without them”

10 / 10
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DsisyInFlorida · Taken for 2 to 5 years May 25, 2015

Imitrex (sumatriptan): “Imatrex has helped me 100% with my cluster headaches. Certain foods trigger these painful headaches and even though I know most of the triggers and even though I try to avoid them its impossible to eat and not have at least one or two of these triggers in my food. My doctor tried me on several pain meds for these headaches but nothing worked. The headaches got so bad I was literally pulling my hair out and was thinking about suicide. Then my doctor gave me Imatrex. As long as I know I have access to Imatrex I am fine. I finally went to a wonderful neurologist who has been very patient in trying other meds to work with the Imatrex. I do take the generic of Imatrex.”

10 / 10
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Strick June 14, 2016

Imitrex (sumatriptan): “I've suffered from cluster headaches since I was 14 years old I'm 35 now. My last headache was in 2013 shortly after my mother passed. I thought I had out grown the headaches but May of 2016 here I go again going into my second month of having them everyday. I've tried imitrex you name it sometimes painkillers work sometimes they don't but like many other cluster headaches suffers Ive been threw hell.I don't know what do I'm a truck driver and it makes it hard to do my job even after the headache have gone. I just wanted to share my experience”

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jenty9 August 19, 2016

“Very bad experience/reaction with only half a dose! 1) Did not take away headache. 2) Increase in pain, heavy weight feeling on my chest, shortness of breath, cold sweats. This med was a nightmare for me! I felt immediate pain and pressure in head, neck and shoulders. The worst however was feeling like a one hundred pound weight on my chest. Additionally, nausea and cold sweats and feeling like I was in big trouble (practically and ER trip)! Beware of this med, it may not be for everyone! Will go back to 3 advil and a coke or my fiorocet. Cure is worse than the disease in this case for me!”

1 / 10
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trixiesmama5825 April 28, 2013

Imitrex (sumatriptan): “I've just started taking Imitrex, the first time I took it, I thought I was getting lock jaw. I was quite worried. I took it again the next day though because it did take care of my headache. Since the first time I took it, the side effects have been minor. Hopefully it stays this way.”

8 / 10
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phodge April 24, 2010

Imitrex (sumatriptan): “I have suffered from cluster headaches for over 15 years and have tried almost everything offered by hospitals and over the counter. I recently was given Imitrex in a nasal spray by my doctor and as long as your nasal passage is clear I have found that about five to ten minutes after you taste it in your throat the headaches go away. It is the best medicine I have ever come across for cluster headaches and my days and nights are much better because of it.”

10 / 10
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Tracy · Taken for 2 to 5 years January 7, 2021

“I have been having cluster headaches for 15 years now. I was just diagnosed 5 years ago, so for the first 10 I was told, "Oh, its just migraines", and was given multiple different medicines to prevent migraine, which obviously didn't help. So now I'm finally taking Verapamil 3 times a day. Every 2 years or so, my clusters come back, and usually only last about a month, I am currently in my episodal period, and has lasted over 2 months now. I take Sumatriptan for when I get a Cluster, but insurance only pays for 9 pills a month. And they work, but 9 a month does not work, because anyone with cluster's, know that you could have 5 or 6 a day.”

9 / 10
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Aquaholic · Taken for 1 to 6 months February 9, 2017

“I've had cluster headaches for about 14 years now, and haven't found any helpful meds until now. Sumatriptan has been extremely helpful for me this cluster period. I use the tablets so it takes about 30 minutes to feel the effects. I take it as soon as I start to feel tension in the head and neck, with the slight onset of a headache. By the time it starts to work, the attack is almost in full force, but once it kicks in the pain immediately subsides and begins to quickly go away. It saves me at least a good hour of the intense, tortuous pain - which also saves me a lot of the side effects of the attacks such as nausea and fatigue. I've found little to no side effects along with the drug, so I'm almost immediately able to function afterwards”

8 / 10
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Yorkshire89 · Taken for 6 months to 1 year June 24, 2017

“After suffering with cluster headaches for two years I was prescribed sumatriptan 100mg tablets which were effective if taken on an empty stomach. They got to work in about 20-30min which saved a good hour or so of debilitating pain, so were great. When the next bout hit I asked about the injections as the tablets didn't always work/work quick enough. Doctor agreed and I got Imigran 6mg. Wow. Just wow. Aborts the headache within a couple of minutes of injection (which is simple and easy). They are a lifesaver and I would recommend anybody who suffers cluster headaches to ask your doctor about it. In the UK they're available on NHS; my doctor was hesitant at first as apparently they cost £25 per 2 injection pack. But they are worth it.”

10 / 10
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Zonie March 31, 2008

Imitrex (sumatriptan): “Imitrex is a wonderful drug for us Cluster Heads. I've not been without one on or about my person for the past 17 years. I'm sure that all of us cluster suffers only wish that they would work a lot faster (like the injectitons), but I am sooooo thankful for them in any form. A real "life saver".”

8 / 10
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Suffering from defective proud · Taken for less than 1 month April 15, 2016

Sumavel DosePro (sumatriptan): “Followed the instructions. Two (2) of the shots were defective (Out of 6). One was harmless and did not fire which only cost me $100 for the non performing shot. The other did nothing until it fired accidentally into my eye. Seeking regulatory and legal help.”

1 / 10
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Anonymous January 25, 2010

Imitrex (sumatriptan): “I consider Imitrex to be the geatest medicine in the world, at least as far as my health is concerned. I am never without the auto injector. When a chronic headache comes on, I inject myself, 3 to 4 minutes later ... no pain. My muscles are fatigued and I'm somewhat tired for about 30 minutes, but NO PAIN! ... Yes!”

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tk7643 · Taken for 5 to 10 years September 8, 2020

“I told my primary care physician of headaches I was having. Not especially severe but very persistent and not responding well to otc meds. It would often require several otc doses over two to three days to obtain relief. He gave me some Relpax samples and I took one at the onset of the next headache. I had relief in about thirty minutes. I was extremely pleased and continued use of the Relpax for perhaps two years until my insurer refused to cover that med any longer due to cost. My primary care prescribed sumatriptan as a replacement. It was equally effective, usually providing relief in as little as fifteen minutes. I used sumatriptan for perhaps three more years, then my headaches simply stopped - completely. Have not had a headache requiring medication in the last six years. Can't explain it, but I'll take it. I never experienced noticeable side effects with either medication. Am currently (sept 2020) 71 year old male.”

10 / 10
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Dmyank April 13, 2010

Imitrex (sumatriptan): “Injections are expensive...but they are the only thing that I have found that work for my cluster headaches. Truly a lifesaver. The burning sensation is ugly, but better than the viciousness ripping of my head to pieces.”

9 / 10
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Sman1166 July 29, 2013

“I'm 46 yrs old and was diagnosed with cluster headaches in my late 20's. I was prescribed sumatriptan last week due to my new spell which started 2 weeks ago, and the medicine is working great for me. When ones coming on, I take a 50mg pill, and it starts working within minutes. I feel and hear crackling noises in my head, as well as my nasal cavity and eye socket, and miraculously it starts to lift away. In some cases though I had to take a second pill because the first didn't work completely, but within 30 to 45 minutes I'm relaxed and pain free. Since they've taken Cafergot off the market I've been without any medicine at all, trying steroids my neurologist experimented with, which didn't work at all. Sumatriptan is working.”

10 / 10
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dezjrrdrs · Taken for 1 to 6 months December 31, 2014

“The first time I used the Dosepro, I was leary. Within 10 minutes I was not only relieved of my migraine, but it was the most clear headed I felt in forever. The second dose I took, I was not near my medicine and I had a full blown migraine, so it wasn't as good but a very close second. I love this. Freedom to make plans and not have to worry about cancelling due to migraine. Yeah!”

10 / 10
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Dan6248 June 12, 2012

Sumavel DosePro (sumatriptan): “It worked to abort a cluster headache. Just as effective, but not any more so, than the needle version of Imitrex/sumatriptan. The injection stung quite a bit and left a fairly nasty welt similar to a wasp sting, and it bled a little bit, but it worked as advertised.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Cluster Headaches

Symptoms and treatments