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Generic name: sumatriptan (transdermal) [ SOO-ma-TRIP-tan ]
Drug class: Antimigraine agents

Medically reviewed by Last updated on Sep 18, 2023.

What is Zecuity?

Zecuity is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Zecuity skin patches are used to treat migraine headaches in adults. Sumatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Zecuity should not be used to treat a common tension headache or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches.


You should not use Zecuity if you have any history of heart disease or coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, circulation problems affecting your intestines, history of a stroke, or if your headache seems to be different from your usual migraine headaches.

Do not use Zecuity if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Do not use Zecuity within 24 hours before or after using another migraine headache medicine.

Before taking this medicine

You should not use Zecuity if you are allergic to sumatriptan, or if you have:

  • coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;

  • a heart disorder called Wolff-Parkinson-White syndrome;

  • a history of heart disease, heart attack, or stroke, including "mini-stroke";

  • untreated or uncontrolled high blood pressure;

  • severe liver disease;

  • circulation problems affecting your intestines; or

  • a headache that seems different from your usual migraine headaches.

Do not use Zecuity if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure Zecuity patches are safe for you, tell your doctor if you have:

  • liver or kidney disease;

  • epilepsy or other seizure disorder;

  • high blood pressure, a heart rhythm disorder; or

  • risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

The Zecuity transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test.

It is not known whether Zecuity will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether sumatriptan transdermal passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Zecuity is not approved for use by anyone younger than 18 years old.

How should I use Zecuity patches?

Your doctor may want to give your first dose of Zecuity in a hospital or clinic setting to quickly treat any serious side effects that occur.

Follow all directions on your prescription label. Do not use Zecuity in larger or smaller amounts or for longer than recommended. Overuse of migraine headache medicine can actually make your headaches worse.

Use Zecuity as soon as you notice headache symptoms, or after an attack has already begun.

Do not take by mouth. Zecuity transdermal is for use only on the skin.

Apply the patch to clean, dry, and hairless skin on your thigh or the outer part of your upper arm. Avoid skin that has scars, tattoos, a rash, or other skin condition. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Do not wear more than one Zecuity skin patch at a time. Using extra skin patches will not make the medication more effective. Never cut a skin patch.

Wear the skin patch for 4 hours, or until the LED dosing light goes out.

After applying a Zecuity skin patch: If your headache does not completely go away, call your doctor before applying a second patch. Choose a different place on your body to apply the second patch. If your headache goes away and then comes back, you may use a second patch if it has been at least 2 hours since you applied the first patch. Do not use more than two (2) patches in 24 hours. If your symptoms do not improve, call your doctor before using any more patches.

You should not use more than 4 Zecuity skin patches in one month. Your blood pressure may need to be checked as you continue to use this medicine.

After removing a Zecuity skin patch: fold it in half firmly with the sticky side in, and throw the patch away in a place where children and pets cannot get to it.

Store at room temperature away from moisture and heat. Do not keep Zecuity skin patches in a refrigerator or freezer.

Keep Zecuity in its original carton and packaging until you are ready to use it.

What happens if I miss a dose?

Since Zecuity is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using Zecuity.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Zecuity skin patches?

Do not bathe, shower, or swim while wearing a sumatriptan transdermal patch.

Do not use Zecuity within 24 hours before or after using another migraine headache medicine, including:

  • sumatriptan tablets, injection, or nasal spray, almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or

  • ergot medicine - dihydroergotamine, ergotamine, ergonovine, methylergonovine.

Sumatriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Zecuity side effects

Get emergency medical help if you have signs of an allergic reaction to Zecuity: hives, severe itching, swelling; feeling light-headed; pounding heartbeats, difficulty breathing; swelling of your face, lips, tongue, or throat.

Remove the Zecuity skin patch and call your doctor at once if you have:

  • severe skin symptoms (redness, pain, discoloration, itching, blistering, peeling, warmth, cracked skin, or open sores) where a patch was worn;

  • sudden and severe stomach pain and bloody diarrhea;

  • severe chest pain, shortness of breath, irregular heartbeats;

  • seizure (convulsions);

  • blood circulation problems - cramps in your hips or legs, tight or heavy feeling in your legs, numbness or tingling in your legs, muscle weakness, burning pain in your feet, pale or blue-colored appearance in your toes;

  • dangerously high blood pressure - severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion;

  • heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or

  • high levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

Common Zecuity side effects may include:

  • pain, numbness, tingling, warmth, itching, or minor irritation where a patch was worn;

  • skin discoloration where a patch was worn; or

  • minor skin redness for up to 24 hours after removing a skin patch.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zecuity skin patches?

Using Zecuity while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use:

  • medicine to treat depression;

  • medicine to treat a psychiatric disorder;

  • a narcotic (opioid) medication; or

  • medicine to prevent nausea and vomiting.

This list is not complete. Other drugs may interact with sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Popular FAQ

Ubrelvy and Imitrex are both oral tablets used to treat migraine, but there are differences in the way they work. Ubrelvy prevents a protein called CGRP thought to play a role in migraine attacks from binding to its receptor and Imitrex is thought to bind to serotonin 5‑HT1B/1D receptors, and inhibit pro-inflammatory substances Although no head-to-head comparison trials compare Ubrelvy to Imitrex, indirect evidence suggests that overall, Ubrelvy is no more effective, and may be inferior to Imitrex at relieving migraine in adults who are able to tolerate triptans. For those adults with moderate-to-severe migraine attacks that cannot tolerate triptans or who have found them ineffective, Ubrelvy is beneficial for treating migraines compared to no treatment. Ubrelvy is associated with fewer side effects than Imitrex, but is more expensive, costing almost twice as much. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zecuity only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.