Galcanezumab Dosage

Medically reviewed by Drugs.com. Last updated on Aug 21, 2023.

Applies to the following strengths: gnlm 120 mg/mL; gnlm 100 mg/mL

Usual Adult Dose for:

Migraine Prophylaxis
Cluster Headache

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Migraine Prophylaxis

Initial dose: 240 mg subcutaneously once
Maintenance dose: 120 mg subcutaneously monthly

Comments:

The first dose is a loading dose consisting of 2 consecutive subcutaneous injections of 120 mg each.
If a dose is missed, administer as soon as possible. Thereafter, dose can be scheduled from the date of the last dose.

Use: For the preventive treatment of migraine.

Usual Adult Dose for Cluster Headache

Initial dose: 300 mg subcutaneously at the onset of the cluster period
Maintenance dose: 300 mg subcutaneously once a month until the end of the cluster period

Comments:

Each dose is administered as 3 consecutive subcutaneous injections of 100 mg each.
This drug is to be injected once a month for the length of a cluster period which may extend from several weeks to months.
If a dose is missed, administer as soon as possible. Thereafter, dose can be scheduled monthly from the date of the last dose.

Use: For the treatment of episodic cluster headaches.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

CONTRAINDICATIONS:

Serious hypersensitivity reaction to this drug or any of the excipients

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

For subcutaneous administration use only
Administer subcutaneously into abdomen, thigh, or back of upper arm or buttocks
Do not inject into areas that are tender, bruised, red, or indurated

MISSED DOSE: If a dose is missed, administer as soon as possible; thereafter, next injection can be scheduled from the date of the last dose

Storage requirements:

Not in use: Refrigerate 36F to 46F (2C to 8C); Protect from light
In-use: Once removed from refrigerator, may keep at temperatures below 86F (30C) for up to 7 days; once removed from the refrigerator, do not put back in the refrigerator
Do not shake; do not freeze; do not expose to extreme heat or direct sunlight

Reconstitution/preparation techniques:

Remove from refrigerator and allow to sit at room temperature from 30 minutes prior to use; do not warm using a heat source such as hot water or microwave
Consult manufacturer's product information for additional information and illustrations

General:

This drug is intended for self-administration; prior to use, patients should be provided with proper training.

Patient advice:

Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
Patients and/or caregivers should be instructed to contact their health care provider if they have questions on administration.
Patients should be informed that hypersensitivity reactions may occur, and they should notify their healthcare provider if they develop.