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Zomig Side Effects

Generic Name: zolmitriptan

Note: This page contains side effects data for the generic drug zolmitriptan. It is possible that some of the dosage forms included below may not apply to the brand name Zomig.

For the Consumer

Applies to zolmitriptan: oral tablet, oral tablet disintegrating

Other dosage forms:

As well as its needed effects, zolmitriptan (the active ingredient contained in Zomig) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking zolmitriptan, check with your doctor immediately:

More common:
  • Chest pain (severe)
  • heaviness, tightness, or pressure in the chest or neck
  • sensation of burning, warmth, heat, numbness, tightness, or tingling
Less common or rare:
  • Abdominal or stomach pain (severe)
  • changes in facial skin color
  • cough or hoarseness
  • diarrhea
  • fast or irregular heartbeat
  • fever or chills
  • hives, itching, or skin rash
  • itching
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • puffiness or swelling of the eyelids or around the eyes, face, or lips
  • tightness in the chest
  • trouble breathing
  • weakness
  • Blurred vision
  • confusion
  • difficulty swallowing
  • dizziness
  • fainting
  • frequent strong or increased urge to urinate
  • headache
  • increased volume of pale, dilute urine
  • nervousness
  • pounding in the ears
  • severe numbness, especially on one side of the face or body
  • slow heartbeat
  • unusual tiredness or weakness
Incidence not known:
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Minor Side Effects

Some zolmitriptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Lack or loss of strength
  • sleepiness or unusual drowsiness
  • warm or cold sensation
Less common:
  • Dizziness or lightheadedness
  • dry mouth
  • feeling of constant movement of self or surroundings
  • sensation of spinning
  • Anxiety
  • crying
  • depersonalization
  • depression
  • dysphoria
  • euphoria
  • hyperventilation
  • irritability
  • loss of memory
  • paranoia
  • problems with memory
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness of the skin
  • seeing, hearing, or feeling things that are not there
  • shaking
  • trouble sleeping
  • welts

For Healthcare Professionals

Applies to zolmitriptan: nasal spray, oral tablet, oral tablet disintegrating


Common (1% to 10%): Chest pain/tightness/pressure and/or heaviness, neck/throat/jaw pain/tightness/pressure, palpitations
Uncommon (0.1% to 1%): Arrhythmias, hypertension, syncope, tachycardia
Rare (less than 0.1%): Angina pectoris, myocardial infarct, coronary vasospasm, QT prolongation, thrombophlebitis[Ref]

Rare reports of serious cardiac adverse events have been reported including acute myocardial infarction within a few hours following administration of this drug.

Chest pain/tightness/pressure and/or heaviness appear to be dose-related occurring in 2%, 3%, and 4% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively. Neck/throat/jaw pain/tightness/pressure occurred in 4%, 7%, and 10% of patients, respectively.[Ref]

Nervous system

Very Common (greater than 10%): Taste disturbances (up to 21%, inhaler)
Common (1% to 10%): Paresthesia, somnolence, dizziness, hyperesthesia
Rare (less than 0.1%): Cerebral ischemia, amnesia, convulsions, ataxia, dystonia, hyperkinesia, hypotonia, hypertonia
Frequency not reported: Serotonin syndrome[Ref]

Paresthesia appears to be a dose-related adverse event occurring in 5%, 7%, and 9% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively.[Ref]


Common (1% to 10%): Warm/cold sensation, heaviness other than chest or neck, pressure/tightness/heaviness, vertigo, asthenia, chills
Uncommon (0.1% to 1%): Tinnitus, hyperacusis, ear pain[Ref]


Common (1% to 10%): Nausea, dry mouth, dysphagia, dyspepsia, abdominal pain, vomiting
Uncommon (0.1% to 1%): Gastroenteritis, increased thirst
Rare (less than 0.1%): Stomatitis, constipation, hematemesis, pancreatitis, melena, ulcer
Very rare (less than 0.01%): Bloody diarrhea, gastrointestinal infarction or necrosis, gastrointestinal ischemic events, ischemic colitis, splenic infarction[Ref]


The most common adverse reactions included neck, throat, jaw pain; dizziness; paresthesia; asthenia; somnolence; warm and cold sensation; nausea; heaviness sensation; and dry mouth. In adolescents treated with the nasal spray, the more commonly reported adverse reactions included dysgeusia, nasal discomfort, dizziness, oropharyngeal pain, and nausea.[Ref]


Uncommon (0.1% to 1%): ecchymosis
Rare (less than 0.1%): Thrombocytopenia, eosinophilia, leucopenia[Ref]


Uncommon (0.1% to 1%): Increased appetite, thirst
Rare (less than 0.1%): Anorexia, hyperglycemia[Ref]


Common (1% to 10%): Arthralgia, myalgia, muscle weakness
Uncommon (0.1% to 1%): Back pain, leg cramps, tenosynovitis
Rare (less than 0.1%): Arthritis, tetanus, twitching[Ref]


Common (1% to 10%): Disorder/discomfort of nasal cavity, throat pain, throat tightness, oropharyngeal pain
Uncommon (0.1% to 1%): Pharyngitis, rhinitis, dyspnea, sinusitis, bronchitis, increased cough, epistaxis, laryngeal edema, hiccup, laryngitis, yawn
Rare (less than 0.1%): Apnea, voice alteration[Ref]


Uncommon (0.1% to 1%): Allergic reactions
Postmarketing reports: Hypersensitivity reactions including angioedema, anaphylactic reactions and anaphylactic shock[Ref]


Rare (less than 0.1%): Diplopia, dry eyes, lacrimation, conjunctivitis, eye pain, visual field defect[Ref]


Uncommon (0.1% to 1%): Polyuria, urinary urgency, cystitis, hematuria
Rare (less than 0.1%): Urinary frequency, miscarriage, dysmenorrhea[Ref]


Common (1% to 10%): Sweating, facial edema
Uncommon (0.1% to 1%): Urticaria, pruritus, rash, photosensitivity reaction
Rare (less than 0.1%): Angioedema[Ref]


Common (1% to 10%): Local irritation or soreness at the site of administration of nasal spray

In clinical trials using the nasal spray approximately 3% (n=460) patients reported local irritation or soreness at the site of administration. Effects were severe in about 1% of patients and approximately 57% resolved in 1 hour. Nasopharyngeal examinations of a subset of patients failed to demonstrate any clinically significant changes with repeated use of the nasal spray.


1. "Product Information. Zomig (zolmitriptan)." Zeneca Pharmaceuticals, Wilmington, DE.

2. Alonso-Navarro H, Jimenez-Jimenez FJ "Myalgia and Cramps Associated With Zolmitriptan." Clin Neuropharmacol 28 (2005): 241-242

It is possible that some side effects of Zomig may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.