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How often can you take Zomig tablets or spray?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Oct 31, 2022.

Official answer


If you’ve taken one Zomig or Zomig-ZMT tablet, or one Zomig nasal spray for your migraine and still need more relief after 2 hours, you can take a second dose. You should not exceed 5 mg per single dose and a total dose of 10 mg in any 24-hour period. Zomig (zolmitriptan) is used to treat (not prevent) migraine headaches.

Zomig (zomitriptan) is a serotonin (5-HT) 1B/1D receptor agonist (often called a “triptan”). The tablet and nasal spray is used for the acute treatment of migraine (with or without aura).

How many Zomig can I take in a day or a week?

You can take two doses of Zomig tablets or nasal spray in a 24-hour period (one day) not to exceed a total dose of 10 mg. The maximum recommended single dose of Zomig is 5 mg.

  • For example if you took the 5 mg Zomig tablet or 5 mg nasal spray when your migraine first started, and your migraine symptoms are not relieved after 2 hours or return, you can take another 5 mg dose within a 24-hour (one day) period from your first dose. There is only 1 dose in each nasal sprayer (2.5 or 5 mg).
  • If you need to treat more than 4 migraine headaches per month with Zomig, contact your healthcare prescriber who can evaluate your treatment or headaches further.
  • This medicine is not meant to be taken everyday to help prevent a migraine. It is used to help stop a migraine that has already started.

How often can I take Zomig?

If you need to treat more than 4 headaches per month with Zomig, contact your doctor for further instructions. You may need a different dose or you may need an alternative medicine. The safety of Zomig in the treatment of an average of more than four headaches in a 30 day period is not known.

Related Questions

Do triptans cause rebound headaches?

Medication overuse of drugs to treat migraine headaches for 10 days or more per month can worsen your headaches. This includes:

  • triptans like Zomig or Imitrex
  • opioids
  • certain ergotamines
  • over-the-counter pain relievers like NSAIDs, aspirin or acetaminophen
  • caffeine
  • a combination of these medicines.

Consider keeping a diary to record your migraine frequency and treatments throughout the month. Report the need for excessive use of migraine treatments to your healthcare provider.

If you use too much Zomig, call your doctor or call emergency medical services (call 911) right away.

What dose of Zomig should I use?

The recommended starting dose of the oral or orally disintegrating tablets is 1.25 mg or 2.5 mg. If you need a 1.25 mg dose, you can break the scored Zomig 2.5 mg tablet in half. Do not break the Zomig-ZMT orally disintegrating tablets in half. The starting dose of the nasal spray is 2.5 mg.

Zomig and Zomig-ZMT (orally-disintegrating) tablets are approved to be used in adults.
Zomig Nasal Spray is used in adults and children 12 years and older.

Always follow your doctor’s instructions on how to take Zomig tablets or nasal spray. Do not change your dose or stop treatment without contacting your doctor first.

This is not all the information you need to know about Zomig (zolmitriptan) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.


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