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Ajovy Side Effects

Generic Name: fremanezumab

Medically reviewed by Last updated on Aug 12, 2020.

Note: This document contains side effect information about fremanezumab. Some of the dosage forms listed on this page may not apply to the brand name Ajovy.

For the Consumer

Applies to fremanezumab: subcutaneous solution

Side effects requiring immediate medical attention

Along with its needed effects, fremanezumab (the active ingredient contained in Ajovy) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fremanezumab:

More common

  • Fast heartbeat
  • fever
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing

Side effects not requiring immediate medical attention

Some side effects of fremanezumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to fremanezumab: subcutaneous solution


The most commonly reported adverse reaction during clinical trials was injection site reactions.[Ref]


Very common (10% or more): Injection site reactions (up to 45%)[Ref]

Injection site reactions included injection site pain, induration, erythema, and pruritus.[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions


Common (1% to 10%): Anti-Drug-Antibodies[Ref]


1. EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL:"

2. "Product Information. Ajovy (fremanezumab)." Nephroceuticals, Miamisburg, OH.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.