What type of drug is Ajovy?
Ajovy (fremanezumab-vfrm) is an injectable calcitonin gene-related peptide antagonist indicated for the preventive treatment of migraine in adults.
People who suffer from migraine have increased levels of calcitonin gene‐related peptide (CGRP), a neuropeptide present in the nervous system. When CGRP binds to its receptor, it results in a cascade of events that contribute to the inflammation associated with migraine pain. Ajovy selectively targets the CGRP ligand and blocks its binding to the receptor, blocking this cascade of events and preventing a migraine attack.
Three other CGRP antagonists have been approved:
- Aimovig (erenumab-aooe) was the first approved CGRP antagonist. Aimovig binds potently and selectively to the CGRP receptor (not the ligand) to block CGRP activation, thereby preventing migraine pain.
- Emgality (galcanezumab-gnlm) has a similar mechanism of action to Ajovy; it binds to the CGRP ligand and blocks its binding to the receptor to help prevent migraine pain.
- Vyepti (eptinezumab-jjmr) also binds to the CGRP ligand and blocks its binding to the receptor.
Read next
Ajovy vs Aimovig: What's the difference between them?
Ajovy and Aimovig are both calcitonin gene-related peptide (CGRP) inhibitors used for migraine prevention in adults. The dosing, side effects, effectiveness and costs of these medicines can vary. As demonstrated in studies, these agents can reduce the number of migraine headache days you experience by about 1.5 to 3 days per month when compared to a placebo (inactive) treatment, but your response may vary. Continue reading
Why does Aimovig cause constipation?
The gastrointestinal (digestive) tract contains CGRP proteins. Some studies suggest that CGRP may play an important role in maintaining the movement of the bowels. Blocking intestinal CGRP with a CGRP antagonist such as Aimovig (erenumab-aooe), a medicine used for migraine prevention, may lead to constipation, which can be severe in some patients. Continue reading
How long does Aimovig last in your system?
It takes approximately 154 days (22 weeks, or over 5 months) for Aimovig to be eliminated out of your system. Aimovig is a prescription medicine injected monthly for the preventive treatment of migraine in adults. Continue reading
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