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What type of drug is Ajovy?

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 30, 2024.

Official Answer by Drugs.com

Ajovy (fremanezumab-vfrm) is an injectable calcitonin gene-related peptide antagonist indicated for the preventive treatment of migraine in adults.

People who suffer from migraine have increased levels of calcitonin gene‐related peptide (CGRP), a neuropeptide present in the nervous system. When CGRP binds to its receptor, it results in a cascade of events that contribute to the inflammation associated with migraine pain. Ajovy selectively targets the CGRP ligand and blocks its binding to the receptor, blocking this cascade of events and preventing a migraine attack.

Three other CGRP antagonists have been approved:

Read next

Ajovy vs Aimovig: What's the difference between them?

Ajovy and Aimovig are both calcitonin gene-related peptide (CGRP) inhibitors used for migraine prevention in adults. The dosing, side effects, effectiveness and costs of these medicines can vary. As demonstrated in studies, these agents can reduce the number of migraine headache days you experience by about 1.5 to 3 days per month when compared to a placebo (inactive) treatment, but your response may vary. Continue reading

Does Ajovy cause weight gain?

Weight gain has not been reported as a side effect in studies with the migraine prevention medicine Ajovy, but some anecdotal reports do note this effect. Other factors, such as lack of physical activity due to migraine pain may play a role in weight gain in patients with migraine headaches. Continue reading

How long does it take for Ajovy to start working?

Most patients usually respond within a month of starting Ajovy treatment, and some respond within one week, if the medicine works for them. In general, Ajovy can help to reduce the number of migraine headache days you have by about 1.5 to 2 days per month. Continue reading

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