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What type of drug is Ajovy?

Medically reviewed by Drugs.com Last updated on Oct 15, 2018.

Official Answer

by Drugs.com

Ajovy is an injectable migraine preventive for adults that targets the calcitonin gene-related peptide (CGRP) and prevents CGRP from binding to its receptor site.

When CGRP binds to the receptor, a cascade of events such as vasodilation and protein leakage begin that leads to the inflammation and pain associated with migraine. Ajovy (fremanezumab-vfrm) from Teva Pharmaceuticals, is a monoclonal antibody and selectively targets the CGRP ligand (a molecule that produces a signal by binding to a site on a target protein).

Two other CGRP antagonists have also been approved:

  • Emgality (galcanezumab-gnlm) from Eli Lilly has a similar mechanism as Ajovy; it binds to the CGRP ligand and blocks its binding to the receptor to help prevent migraine pain.
  • Aimovig (erenumab-aooe) from Amgen was the first approved CGRP antagonist and works in a slightly different way than Ajovy or Emgality. Aimovig actually binds potently and selectively to the CGRP receptor (not the ligand) to block CGRP activation, thereby preventing the migraine pain.

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