Olmesartan Dosage

Medically reviewed by Drugs.com. Last updated on Apr 28, 2021.

Applies to the following strengths: 5 mg; 20 mg; 40 mg

Usual Adult Dose for Hypertension

20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed.

Maximum dose: 40 mg orally once a day

Comments:

For patients with possible intravascular volume depletion (e.g., patients treated with diuretics, especially those with impaired renal function), initiate this drug under close supervision and give consideration to a lower starting dose.
Twice daily dosing offers no additional benefit over the same total dose give once daily.

Usual Pediatric Dose for Hypertension

6 to 16 years:

20 to less than 35 kg: 10 mg orally once a day; may increase dose to 20 mg in two weeks if further blood pressure reduction is needed
35 kg or more: 20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed

Comments:

For children who cannot swallow tablets, the same dose can be given using an extemporaneous suspension.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

US BOXED WARNING:

FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin angiotensin system (RAS) can cause injury and death to the developing fetus.

Safety and efficacy have not been established in patients younger than 1 year; this drug has not been shown to be effective for hypertension in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

Extemporaneous suspension: Refrigerate at 2 to 8C; may store up to 4 weeks.

Reconstitution/preparation techniques (200 mL of a 2 mg/mL suspension):

Add 50 mL purified water to an amber polyethylene terephthalate (PET) bottle containing twenty, 20 mg tablets of this drug and allow to stand for at least 5 minutes.
Shake the container for at least 1 minute and allow to stand for at least another minute. Repeat 4 additional times.
Add 100 mL Ora-Sweet(R) and 50 mL Ora-Plus(R) and shake well for at least 1 minute.
Shake well before each use and return to refrigeration promptly.

Monitoring:

Monitor serum electrolytes periodically.
Monitor serum creatinine periodically in patients with impaired renal function.

Patient advice:

Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.