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Lisinopril Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 26, 2021.

Summary

Commonly reported side effects of lisinopril include: dizziness, hypotension, hyperkalemia, increased blood urea nitrogen, and increased serum creatinine. Other side effects include: headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lisinopril: oral extemporaneous suspension, oral tablets

Warning

  • May cause fetal and neonatal morbidity and mortality if used during pregnancy.1 2 3 4 74 75 (See Fetal/Neonatal Morbidity and Mortality under Cautions.)

  • If pregnancy is detected, discontinue lisinopril as soon as possible.1 2 3 4 75

Side effects include:

Patients with hypertension: Headache, dizziness, cough, fatigue, diarrhea, upper respiratory tract infection, nausea. With fixed combination preparation, muscle cramps, asthenia, orthostatic effects, paresthesia.

Patients with heart failure: Dizziness, hypotension, headache, diarrhea, chest pain, nausea, abdominal pain, rash, upper respiratory tract infection.

Patients with acute MI: Hypotension, renal dysfunction.

For Healthcare Professionals

Applies to lisinopril: oral solution, oral tablet

Cardiovascular

Very common (10% or more): Hypotension (11%)

Common (1% to 10%): Chest pain, angina pectoris, orthostatic hypotension, palpitations

Uncommon (0.1% to 1%): Angioneurotic edema, myocardial infarction or cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon[Ref]

Hypotension is most likely in patients who are sodium and intravascular volume depleted. In large studies, patients have reported "heart pounding" and chest pain, although the relationship to lisinopril is questionable.[Ref]

Renal

Common (1% to 10%): Creatinine increased (10%)

Very rare (less than 0.01%): Renal insufficiency[Ref]

Nervous system

Very common (10% or more): Dizziness (19%)

Common (1% to 10%): Headache, syncope

Uncommon (0.1% to 1%): Paresthesias[Ref]

Respiratory

Common (1% to 10%): Creatinine increased (10%)

Uncommon (0.1% to 1%): Rhinitis

Very rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia[Ref]

A study has revealed a significantly higher incidence of discontinuation of angiotensin converting enzyme inhibitor therapy due to cough among black patients compared with nonblack patients (9.6% vs. 2.4%).[Ref]

Metabolic

Common (1% to 10%): Hyperkalemia

Frequency not reported: Gout, hypoglycemia in diabetic patients receiving ACE inhibitors when concurrently treated with oral antidiabetic agents or insulin[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, vomiting

Frequency not reported: Pancreatitis, constipation, flatulence, dry mouth, taste disturbance[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Angioedema[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus, erythema

Rare (0.01% to 0.1%): Alopecia, urticaria, psoriasis, hypersensitivity/angioedema, angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx

Very rare (less than 0.01%): Sweating, skin lesions, skin infections, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, cutaneous pseudolymphoma

Frequency not reported: Photosensitivity, flushing, diaphoresis[Ref]

Hematologic

Very rare (less than 0.01%): Bone marrow depression, hemolytic anemia, leukopenia/neutropenia, thrombocytopenia, decreases in hemoglobin, decreases in hematocrit[Ref]

Psychiatric

Rare (0.01% to 0.1%): Memory impairment, confusion, somnolence, irritability, nervousness, hallucinations

Very rare (less than 0.01%): Mania

Hepatic

Common (1% to 10%): Creatinine increased

Very rare (less than 0.01%): Cholestatic jaundice that progresses to fulminant hepatic necrosis and sometimes death (discontinue of therapy if jaundice or markedly elevated hepatic serum enzymes develop)

Endocrine

Very rare (less than 0.01%): Diabetes, syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Other

Common (1% to 10%): Cough

Frequency not reported: Fatigue, asthenia, orthostatic effects, tinnitus, olfactory disturbance

Genitourinary

Uncommon (0.1% to 1%): Impotence

Rare (less than 0.1%): Gynecomastia

Frequency not reported: Proteinuria

Frequently asked questions

References

1. "Product Information. Prinivil (lisinopril)." Merck & Company Inc (2002):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp." (2006):

4. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.