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Lisinopril Side Effects

In Summary

Commonly reported side effects of lisinopril include: dizziness, hypotension, hyperkalemia, increased blood urea nitrogen, and increased serum creatinine. Other side effects include: headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lisinopril: oral solution, oral tablet

Along with its needed effects, lisinopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lisinopril:

More Common

  • Blurred vision
  • cloudy urine
  • confusion
  • decrease in urine output or decrease in urine-concentrating ability
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness

Less Common

Rare

  • Arm, back, or jaw pain
  • chest discomfort, tightness, or heaviness
  • fast or irregular heartbeat
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • shivering
  • trouble sleeping

Some side effects of lisinopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

  • Decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • rash

Rare

  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • muscle cramps
  • sensation of spinning
  • stomach discomfort or upset
  • swelling

For Healthcare Professionals

Applies to lisinopril: oral solution, oral tablet

Cardiovascular

Hypotension is most likely in patients who are sodium and intravascular volume depleted. In large studies, patients have reported "heart pounding" and chest pain, although the relationship to lisinopril is questionable.[Ref]

Very common (10% or more): Hypotension (11%)

Common (1% to 10%): Chest pain, angina pectoris, orthostatic hypotension, palpitations

Uncommon (0.1% to 1%): Angioneurotic edema, myocardial infarction or cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon[Ref]

Renal

Common (1% to 10%): Creatinine increased (10%)

Very rare (less than 0.01%): Renal insufficiency[Ref]

Nervous system

Very common (10% or more): Dizziness (19%)

Common (1% to 10%): Headache, syncope

Uncommon (0.1% to 1%): Paresthesias[Ref]

Respiratory

A study has revealed a significantly higher incidence of discontinuation of angiotensin converting enzyme inhibitor therapy due to cough among black patients compared with nonblack patients (9.6% vs. 2.4%).[Ref]

Common (1% to 10%): Creatinine increased (10%)

Uncommon (0.1% to 1%): Rhinitis

Very rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia[Ref]

Metabolic

Common (1% to 10%): Hyperkalemia

Frequency not reported: Gout, hypoglycemia in diabetic patients receiving ACE inhibitors when concurrently treated with oral antidiabetic agents or insulin[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, vomiting

Frequency not reported: Pancreatitis, constipation, flatulence, dry mouth, taste disturbance[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Angioedema[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus, erythema

Rare (0.01% to 0.1%): Alopecia, urticaria, psoriasis, hypersensitivity/angioedema, angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx

Very rare (less than 0.01%): Sweating, skin lesions, skin infections, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, cutaneous pseudolymphoma

Frequency not reported: Photosensitivity, flushing, diaphoresis[Ref]

Hematologic

Very rare (less than 0.01%): Bone marrow depression, hemolytic anemia, leukopenia/neutropenia, thrombocytopenia, decreases in hemoglobin, decreases in hematocrit[Ref]

Psychiatric

Rare (0.01% to 0.1%): Memory impairment, confusion, somnolence, irritability, nervousness, hallucinations

Very rare (less than 0.01%): Mania

Hepatic

Common (1% to 10%): Creatinine increased

Very rare (less than 0.01%): Cholestatic jaundice that progresses to fulminant hepatic necrosis and sometimes death (discontinue of therapy if jaundice or markedly elevated hepatic serum enzymes develop)

Endocrine

Very rare (less than 0.01%): Diabetes, syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Other

Common (1% to 10%): Cough

Frequency not reported: Fatigue, asthenia, orthostatic effects, tinnitus, olfactory disturbance

Genitourinary

Uncommon (0.1% to 1%): Impotence

Rare (less than 0.1%): Gynecomastia

Frequency not reported: Proteinuria

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. "Product Information. Prinivil (lisinopril)." Merck & Co, Inc, West Point, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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