Skip to main content

User Reviews for Nitroglycerin

Also known as: Nitrostat, Nitro-Bid, Nitro-Dur, Rectiv, Minitran, NitroMist, Nitrolingual Pumpspray, Nitro-Time Deponit Nitro TD Patch-A GoNitro Nitrostat Tablets …show all brand names

Nitroglycerin has an average rating of 7.6 out of 10 from a total of 51 ratings on Drugs.com. 68% of reviewers reported a positive experience, while 13% reported a negative experience.

Condition Avg. Rating Reviews Compare
Anal Fissure and Fistula  
7.3
34 reviews 1 medications
Angina  
8.6
8 reviews 132 medications
Angina Pectoris Prophylaxis  
10.0
2 reviews 132 medications
Heart Attack  
9.5
2 reviews 125 medications
High Blood Pressure  
1.0
2 reviews 267 medications
Raynaud's Syndrome  
10.0
2 reviews 32 medications
Heart Failure  
10.0
1 reviews 124 medications
Summary of Nitroglycerin reviews 7.6 51 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Nitroglycerin

Anonymous · March 7, 2010

Nitrostat (nitroglycerin) for Angina: “My cardiologist recommend this drug to relieve shortness of breath at night due to atrial fibrillation. The sublingual 0.4 mg tablet gives a slight burning sensation under the tongue, which is not uncomfortable. A slight headache was felt on the forehead but was of short duration. The immediate dilation of the blood vessels achieves relief within one minute. Very positive results.”

8 / 10
Was this helpful?YesNo
JustAGuy · Taken for less than 1 month · February 13, 2020

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “Dealt with anal fissures for multiple years. Lived in 24/7 anxiety. Spent countless hours researching the internet for solutions. Felt like I was becoming as knowledgeable as a colorectal surgeon. First couple of times I tried Rectiv, the headaches were INSANE. Very intense. To the point I quit taking. I started up again and dealt with it and after a couple of days, the headaches went away—as did my symptoms. The .4% nitro solution can be made into a .2% compound at a speciality pharmacy — which will ease the headaches. (And only cost $17!!) Bottom line is: the stuff works.”

9 / 10
Was this helpful?YesNo
Costly Relief · Taken for less than 1 month · December 6, 2021

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I have been struggling with an anal fissure for about 3 months. Tried prescription strength lidocaine which didn’t help at all. Today my Doctor prescribed Rectiv and I have to say it really really works to alleviate the pain in my butt. That’s the good news. The bad news is within literally 5 minutes of applying an inch of Rectiv, I am experiencing one of the worst headaches I have ever had. It is excruciating to even look at this screen. Took over the counter headache meds but after three hours still no relief from the headache. It’s almost worse than the pain from the fissure. Almost but not quite. The other problem with this medication is my insurance will only cover 20% of the cost, that means I paid $499.00 out of pocket for one tube of this ointment!! This is unacceptable, drug manufacturers and insurance companies have got to get together and work this out so average people can afford this care. If I was on a fixed income there would be no way to get access.”

8 / 10
Was this helpful?YesNo
Bill Durham · Taken for less than 1 month · January 12, 2020

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “Suffered excruciating butt pain on and off over the last year. The anticipation of another bowel movement caused great anxiety. Tried diet change and fiber supplements. Started applying Rectiv three days ago. On my fourth day. All pain has subsided. Very slight “tingle” in my head when initially used each time. Wouldn’t consider it a headache, but more of an indication the medication was taking effect. Dr. prescribed the day before I was leaving for vacation to the Keys. Writing this on the beach - pain free.”

10 / 10
Was this helpful?YesNo
Ameyls · May 31, 2017

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I struggled with intense pain and bleeding due to a fissure for several months. Assuming it was hemmorhoids, I tried multiple over the counter medicines, but nothing worked. My OB/Gyn was the one who realized it was a fissure and prescribed Rectiv. The headaches were rough at first, and I almost quit using the ointment because of them. I'm so glad I didn't, though. Within one week, the headaches were gone, and my fissure symptoms were calming down. By week two, I was totally back to normal--no pain, no bleeding. I continued using it for another week, just to be sure I was completely healed. I've been off it for two weeks now, and I'm still symptom-free. I can't sing the praises of this medicine enough!!”

9 / 10
Was this helpful?YesNo
Relief · Taken for less than 1 month · September 4, 2018

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I suffered for over a year with a anal fissure that was so painful I’d lay in the bath 3-4 times a day to get relief. It was also infected and was leaking a horrible smelly clear discharge. I finally went to the doctor and had it checked out. He prescribed this to see if it would work and within a couple weeks I was healed and had 0 pain. The headaches only last a week or less from the first use. This stuff is amazing and I can’t praise it enough. I thought I was gonna have to deal with the excruciating pain for forever.”

10 / 10
Was this helpful?YesNo
vigra · January 18, 2009

Nitro-Bid (nitroglycerin) for Raynaud's Syndrome: “I am 60 years old and have had Raynaud's Syndrome for 10 years. The first episode was when I was diagnosed, when I looked like I would lose a finger from severe frostbite. However a wonderful surgeon told me to try Nitro-Bid cream on that finger for 7 days, before resorting to removing the finger. It was miraculous as within those 7 days my skin started to renew itself and the sheer pain of it all was gone within 3 days. He saved my index finger on my left hand and I was extremely grateful.”

10 / 10
Was this helpful?YesNo

Frequently asked questions

Ughhhh · Taken for less than 1 month · April 18, 2020

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “Worst headache ever instantly after application of Rectiv. It does alleviate the rectal hell I've experienced. I am miserable and I'm just praying this heals. I DON'T KNOW HOW MUCH LONGER I CAN DO THE FISSURE OR THIS MEDICATION.”

5 / 10
Was this helpful?YesNo
JL · May 10, 2021

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “After countless visits to the doctor, an emergency room physician figured out I had a fissure and not hemorrhoids. For the side effect of headache? Take some Advil and drink some water and it doesn’t even hurt anymore. This medication works. In the three days I’ve been using it, my pain has reduced substantially and my bleeding has stopped.”

9 / 10
Was this helpful?YesNo
scaredy cat · Taken for less than 1 month · January 27, 2021

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “This medicine sat on my shelf for over 6 months - I was so afraid of the 'worst headache ever' described in many posts. I finally became desperate enough to use it, and am on 5th day now. Please don't be afraid to try this. It has absolutely helped the fissure. No pain or blood the last 3 days (after over 1 year of pain and bleeding). Every application I do get an unpleasant pressure sensation in my head immediately (which is creepy), but it does go away in an hour. Only once was it a full on headache and I think I used too much of the product. But not even so bad of headache that I took tylenol or advil for it. Be very careful to only apply the 1 inch amount. The product does burn my skin a bit - I suspect the PEG or lanolin ingredients. If I ever need it again I would ask about a compounding pharmacy preparing a hypo-allergenic version. I am F, 5'7 weight 120. I am usually very sensitive to medicines and often choose pediatric dosed of products.”

9 / 10
Was this helpful?YesNo
AP · Taken for less than 1 month · April 28, 2020

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I've been using this ointment for three days now and just started noticing that bowel movements are less painful. The headache side-effect is a real thing but for me, isn't strong and only lasts for about 20-30 minutes. It does happen every single time though and it's almost instant. My insurance did cover this but I still paid $80.00 for one tube.”

7 / 10
Was this helpful?YesNo
Bear Man · Taken for less than 1 month · August 24, 2015

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I developed anal fissures after using Invokamet and Invokana. My GI Dr. prescribed Rectiv to heal them. It worked! However, I got an instant Migraine each time. You cannot take aspirin, so I took my Migraine medicine - Fiorcet. It took about two weeks to heal. A real godsend! Only downfall was the cost - $525.00 per tube. Insurance covered it, thankfully!”

8 / 10
Was this helpful?YesNo
Fissureman · Taken for less than 1 month · June 10, 2021

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “My advice is to take 2 tylenol extra strength or, ibuprofen 15 min before applying nitroglycerin ointment to the anal area, this will help with the headache that you will get. Use a (small dab) -like on a cotton swab- and apply to the "outside" of the anus. Inside application and your asking for a "tear your head apart headache".... Do this at night when you are home for the day. I wouldn't advise using this before or during the work day. Because you can experience a back of the head migraine for around 1-2 hours. And you more than likely won't make it through the work day.”

7 / 10
Was this helpful?YesNo
RN · Taken for less than 1 month · August 15, 2019

For Anal Fissure and Fistula: “Im a GI nurse and I was in so much pain, tried to self manage thinking it was only hemorrhoids but in fact I had a good size fissure and was prescribed this. Yes it is expensive I was almost tempted to leave it at the pharmacy but I decided that I needed to just take care of the issue. First dose was scary, I had palpations, I was sweating and I instantly got a headache. For my second dose I used a little less (pea sized) and it was okay. Yes there is a headache but it went away within an hour. I’m on day 3 and I’m already seeing an improvement. I don’t think I would use it for 3 weeks like I was prescribed but yes meds work. FYI, use gloves when handling this med.”

7 / 10
Was this helpful?YesNo
AL54 · Taken for less than 1 month · July 22, 2020

For Anal Fissure and Fistula: “This part of the Leaflet my hospital NHS gave me • About 60-70% people with a chronic anal fissure are cured with a 6-8 week course of GTN. Therefore, the chance of a cure by using GTN is better than with the supportive method alone • You should rub a pea size amount of the ointment into the skin around the rim of the anus 2-3 times a day. Do not push it inside the anus. If you do, it will be absorbed into the blood stream 3 and you are more likely to get side effects, such as a headache • It is important that you complete the full course of treatment, as it may take 6-8 weeks of treatment for the fissure to heal fully. However symptoms such as pain may ease quickly Hope it helps guys and girls”

8 / 10
Was this helpful?YesNo
Principe · February 24, 2016

For Angina: “I have had heart disease for many years and always have a bottle (tiny!) of sub-lingual nitros in my pocket. When I feel chest pain, one under the tongue and the pain goes away, in my case, every time. The nitro works very quickly to dilate your blood vessels allowing more blood and oxygen to get to your heart muscle. Ask your doctor how to proceed should one pill not relieve the pain. Sub-linguals have a limited life once the bottle is opened the first time, about 3-6 months. If you find yourself using all the pills within that time (25 tiny tablets, typically), then they are best. If you only need it occasionally, get the pump spray as it has a much longer life. It is, however, more expensive.”

10 / 10
Was this helpful?YesNo
Julie · March 23, 2018

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “This is a fantastic medication.I was trying everything over the counter and nothing really helped till my doctor put me on rectiv. I thank god for this medication and my doctor for prescribing it. Within 3 days of use the pain subsided and I felt a major difference. I'm back to my old self again ”

10 / 10
Was this helpful?YesNo
virbull · Taken for 10 years or more · April 18, 2020

Nitrolingual Pumpspray (nitroglycerin) for Angina: “I have used nitrolingual spray for about 10 years now and hate going out anywhere without it. Just a note though. On the bottle it says "200 doses" ..... absolutely no way. Further, about 8mm height of the liquid is left in each bottle and not able to be dispensed. Surely a better designed bottle/dispenser is not that hard to come up with. That's probably over 300mm in depth wasted over the 10 years I have used the product. Plus, I will be out walking and need the spray. Seeing there seems to be plenty in the bottle I take it with me. Everytime I get caught and am not able to spray any of the product.”

9 / 10
Was this helpful?YesNo
AF · Taken for 1 to 6 months · July 21, 2021

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I developed a fissure just before the pandemic and was only able to get a virtual appointment. I was prescribed Rectiv and it did provide relief. I experienced a dull, but unpleasant headache for a couple of weeks before I adjusted and the headaches improved and eventually went away. It did help with pain relief and some healing, but the fissure never healed and I ended up having a surgical procedure to repair it.”

7 / 10
Was this helpful?YesNo
MK · Taken for 1 to 6 months · August 20, 2018

For Anal Fissure and Fistula: “I have had a fissure for a months now. Thinking it was a hemorrhoid I tried to treat it myself. Unfortunately for me the pain go worse one day and was SO bad I had to go to the ER. Just so they could prescribe me some kind of pain killer.....which they didn't do. Fast forward two weeks and I have an appointment with a specialist. He applies the cream for inspection and just that small amount for the digital exam was enough to give me almost INSTANT pain relief. Instant as in a few minutes later the pain was bearable enough where I could sit and sleep. If you are having symptoms of hemorrhoids just go in and get your body checked out. I was in high school when I got my first one and did not have any kind of rectal exam due to embarrassment until I was 25. Don't be me. Get an exam and get relief. and get it fixed Just don't go to a crappy ER like I did.”

10 / 10
Was this helpful?YesNo
Ardleystar · March 27, 2012

For Angina: “This spray is very effective in eradicating nocturnal angina pain and as a precursor to physical exercise thereby inhibiting pain. Very effective pain reliever in a convenient delivery system, fantastic!”

10 / 10
Was this helpful?YesNo
tnurse · March 10, 2014

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I'm on day 2 of this product and I "feel" a drastic difference. I am forever grateful to my doctor for prescribing this. 3 years ago I had the same issue and I suffered for 3 months with excruciating pain during my bowel movement to the point I added to my misery by holding it for up to a week at a time to suffer from as few painful bowel motions as possible all because I was to embarrassed to show this problem to my doctor. Never again and I really thank the pharmacist for the coupon to bring my cost down to 40 dollars. There is a mild side effect I didn't have a headache more so painless throbbing in my head for the first 1-2 after application. I was still able to function and get through my clinicals without feeling faint or ill.”

9 / 10
Was this helpful?YesNo
Mfish · January 23, 2020

Rectiv (nitroglycerin) for Anal Fissure and Fistula: “I have never had such a severe headache in my life. Made the mistake of using before bed. Headache kept me up all night into the morning finally had to take caffeine pills to try to constrict the blood vessels in my head. I will NEVER use this again. Rather have pain my my butt the feel like my head is being ripped apart.”

1 / 10
Was this helpful?YesNo
K9 · December 2, 2020

For Angina: “The only variable in my routine is that I took Valerian Root to help me sleep. I have been using it for a week following the directions on the bottle. It wasn't having any affect helping me sleep so I increased the dose. Within 30 minutes of taking it my heart symptoms started, severe pain etc. I decided to try nitroglycerin instead of calling an ambulance for several reasons including not wanting to get COVID at the hospital. It mostly relieved the chest pain, but only temporarily so I took more nitroglycerin for a total of 4 times, one pill at a time with the same results. After 6 hours the pain went away. I am not going to take Valerian Root again and I hope that I won't experience chest pain. Today I feel horrible, dull headache, tingling hands, listless, out of it mentally, and sluggish physically. But no more chest pain. I attribute these feelings to nitroglycerin.”

6 / 10
Was this helpful?YesNo
for Pop · September 26, 2013

Nitro-Bid (nitroglycerin) for Heart Attack: “My dad is in the last stages of congestive heart failure. This mainly means he still functions as much as he can but will continue to degrade. His heart seemed to hurt very consistently. His Dr. gave him Nitro-bid. He applied it as a cream to the chest area 1 or 2 times a day. After less than 2 months he was only using it as needed which was perhaps 1-2 times a month. A very good, fast acting addition to comfort care.”

10 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.