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Nitroglycerin (topical)

Generic name: nitroglycerin (topical) [ NYE-troe-GLIS-er-in ]
Brand names: Nitro-Bid, Nitrol Appli-Kit topical
Dosage form: transdermal ointment (2%)
Drug classes: Antianginal agents, Vasodilators

Medically reviewed by Drugs.com on Aug 16, 2023. Written by Cerner Multum.

What is nitroglycerin topical?

Nitroglycerin is used to prevent attacks of chest pain (angina).

Nitroglycerin may also be used for purposes not listed in this medication guide.

Nitroglycerin topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Nitroglycerin may cause serious side effects. Call your doctor at once if you have:

Nitroglycerin can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop taking nitroglycerin. Ask your doctor before using any headache pain medication.

Common side effects of nitroglycerin may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use this medicine if you are also using medicine to treat pulmonary arterial hypertension or erectile dysfunction.

Before taking this medicine

You should not use nitroglycerin if you are allergic to it.

Do not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are using nitroglycerin topical. Using erectile dysfunction medicine with nitroglycerin can cause a sudden and serious decrease in blood pressure.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How should I use nitroglycerin topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Nitroglycerin topical is usually applied 2 times daily. Follow your doctor's instructions carefully.

Wash your hands after applying nitroglycerin.

Do not take by mouth. Topical medicine is for use only on the skin.

Nitroglycerin topical will not work fast enough to treat an angina attack that has already begun. Your doctor may prescribe an oral form of nitroglycerin (tablet, capsule, spray) to treat an angina attack. Talk with your doctor if any of your medicines do not seem to work as well in treating or preventing angina attacks.

If you need to have any type of surgery or dental work, tell the surgeon or dentist ahead of time that you are using nitroglycerin topical.

Store this medicine at room temperature, away from moisture and heat.

amlodipine, lisinopril, aspirin, metoprolol, losartan, furosemide, carvedilol, hydrochlorothiazide, clopidogrel, spironolactone

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of nitroglycerin can be fatal.

Overdose symptoms may include a severe throbbing headache, confusion, fever, fast or pounding heartbeats, dizziness, vision problems, vomiting, bloody diarrhea, trouble breathing, cold or clammy skin, fainting, and seizures.

What should I avoid while using nitroglycerin topical?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol can increase certain side effects such as dizziness, drowsiness, feeling light-headed, or fainting.

What other drugs will affect nitroglycerin topical?

Tell your doctor about all your current medicines, especially:

This list is not complete and many other drugs may affect nitroglycerin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does nitroglycerin interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Popular FAQ

How do you take GoNitro to treat an angina attack (chest pain)?

To treat an angina attack place the contents of one or two packets of GoNitro powder under the tongue at the onset of the attack. Follow the seven steps for how best to administer the contents of the packet.

An additional packet can be administered every five minutes as required.

Do not use more than three packets within 15 minutes.

Seek medical help straight away if chest pain persists after three packets of GoNitro have been administered. Continue reading

More FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.