Skip to main content


Generic name: nitroglycerinNYE-troe-GLI-ser-in ]
Drug classes: Antianginal agents, Vasodilators

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jul 13, 2021.

What is Nitromist?

NitroMist belongs to a group of drugs called nitrates. Nitroglycerin dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Nitromist is used to treat or prevent attacks of chest pain (angina).

NitroMist is a metered aerosol spray and each dose should be should be sprayed onto or under the tongue.


You should not use Nitromist if you are also using medicine to treat pulmonary arterial hypertension (PAH). Do not take erectile dysfunction medicine (Viagra, Cialis, Levitra and others) while you are using Nitromist.

You should not use Nitromist if you have severe anemia, increased pressure inside your skull, circulation problems, chest pain that spreads to your jaw or shoulder, or signs of shock (pale skin, suddenly feeling light-headed).

Seek emergency medical attention if you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, general ill feeling).

Get emergency medical help if you still have chest pain after using a total of 3 doses in 15 minutes, or if you have chest pain that seems unusual.

Before using this medicine

You may not be able to use Nitromist if you have:

  • severe anemia (low red blood cells);

  • increased pressure inside the skull;

  • circulation problems or shock (pale or clammy skin, cold sweat, numbness or tingling, fast or irregular heartbeats, or feeling like you might pass out); or

  • if you also take riociguat or vericiguat.

Do not use erectile dysfunction medicine (such as Viagra, Cialis, or Levitra) or you could have a sudden and serious decrease in blood pressure.

To make sure Nitromist is safe for you, tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

Nitromist is not approved for use by anyone younger than 18 years old.

How should I use Nitromist?

Use Nitromist exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Try to rest or stay seated when you use Nitromist (may cause dizziness or fainting).

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use this medicine at the first sign of chest pain. Use another dose every 5 minutes as needed, up to a total of 3 doses.

Get emergency medical help if you still have chest pain after using a total of 3 doses in 15 minutes, or if your chest pain seems unusual.

You may use Nitromist spray within 5 to 10 minutes before an activity that might cause chest pain.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Nitromist.

If you use Nitromist on a regular schedule to prevent angina, do not stop using it suddenly or you could have a severe attack of angina. Keep this medicine on hand at all times. Get your prescription refilled before you run out of medicine completely.

Store Nitromist at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Angina Pectoris:

1 to 2 sprays (0.4 to 0.8 mg) on or under tongue every 5 minutes as needed, up to 3 sprays in 15 minutes. If pain persists after maximum dose, prompt medical attention is recommended

Usual Adult Dose for Angina Pectoris Prophylaxis:

1 to 2 sprays (0.4 to 0.8 mg) on or under tongue 5 to 10 minutes prior to activity that might precipitate an acute attack.

What happens if I miss a dose?

If you use Nitromist on a regular schedule, skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of nitroglycerin can be fatal.

Overdose symptoms may include a throbbing headache, confusion, pounding heartbeats, vision problems, vomiting, bloody diarrhea, sweating, clammy skin, blue lips, weak or shallow breathing, loss of movement, seizure, or fainting.

What should I avoid while using Nitromist?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol can increase certain side effects such as dizziness, drowsiness, feeling light-headed, or fainting.

Nitromist side effects

Get emergency medical help if you have signs of an allergic reaction to Nitromist: hives, sweating, pale skin; nausea, vomiting; feeling weak or light-headed; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe or throbbing headaches that do not become less severe with continued use of Nitromist;

  • pounding heartbeats or fluttering in your chest;

  • slow heart rate;

  • a light-headed feeling, like you might pass out;

  • blurred vision or dry mouth; or

  • heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Nitromist can cause severe headaches that should become less severe as you continue to use the medicine.

Common Nitromist side effects may include:

  • flushing (sudden warmth, redness, or tingly feeling);

  • feeling light-headed, fainting;

  • headache, dizziness; or

  • numbness, tingling, burning pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nitromist?

Tell your doctor about all your current medicines, especially:

This list is not complete and many other drugs may interact with nitroglycerin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

To treat an angina attack place the contents of one or two packets of GoNitro powder under the tongue at the onset of the attack. Follow the seven steps for how best to administer the contents of the packet.

An additional packet can be administered every five minutes as required.

Do not use more than three packets within 15 minutes.

Seek medical help straight away if chest pain persists after three packets of GoNitro have been administered. Continue reading

More FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Nitromist only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.