Generic Name: nitroglycerin (rectal) (NYE troe GLIS er in)
Brand Names: Rectiv
Medically reviewed on November 17, 2017
What is Rectiv?
Rectiv Ointment contains nitroglycerin, a nitrate that dilates (widens) blood vessel.
Rectiv is used to treat moderate to severe pain caused by chronic anal fissures (tears in the skin lining your rectum).
Rectiv may also be used for purposes not listed in this medication guide.
You should not use Rectiv if you have: severe anemia (a lack of red blood cells), or a brain injury, hemorrhage, or tumor.
You also should not use this medicine if you are using medicine to treat pulmonary arterial hypertension (PAH), such as riociguat, (Adempas), sildenafil (Revatio), or tadalafil (Adcirca).
Do not take erectile dysfunction medicine (Viagra, Cialis, and others) while you are using Rectiv, or you could have a sudden and serious decrease in blood pressure.
Before using Rectiv, tell your doctor if you have congestive heart failure, low blood pressure, glaucoma, liver disease, migraine headaches, or a history of heart attack, stroke, or circulation problems.
Do not use Rectiv without the advice of a doctor if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling). Seek emergency medical attention if you have symptoms of a heart attack.
Rectiv can cause severe headaches, which may occur each time you use the medication. Your doctor may recommend treating fever and pain with an aspirin free pain reliever such as acetaminophen (Tylenol). Follow the label directions or your doctor's instructions about how much of this medicine to use.
Before taking this medicine
You should not use Rectiv if you are allergic to:
isosorbide mononitrate; or
other forms of nitroglycerin (pill, spray, or skin ointment, or skin patch).
Do not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are using Rectiv. Using erectile dysfunction medicine with nitroglycerin can cause a sudden and serious decrease in blood pressure.
You also should not use Rectiv if you have:
severe anemia (a lack of red blood cells); or
a brain injury, hemorrhage, or tumor.
Do not use Rectiv if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling). Seek emergency medical attention if you have symptoms of a heart attack.
To make sure Rectiv is safe for you, tell your doctor if you have:
congestive heart failure;
a history of heart attack, stroke, or circulation problems;
low blood pressure;
migraine headaches; or
FDA pregnancy category C. It is not known whether Rectiv will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether nitroglycerin rectal passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Rectiv is not approved for use by anyone younger than 18 years old.
How should I use Rectiv?
Use Rectiv exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Rectiv can cause severe headaches. Ask your doctor before using any headache pain medication.
It may take up to 3 weeks before your symptoms improve. Keep using as directed and tell your doctor if your symptoms do not improve or if they get worse while using Rectiv. Do not use this medicine for longer than 3 weeks unless your doctor tells you to.
Store at room temperature away from moisture and heat. Keep the tube tightly closed when not in use. Throw away any Rectiv ointment you have not used within 8 weeks after you first opened the tube.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Rectiv?
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin, such as dizziness, drowsiness, feeling light-headed, or fainting.
Rectiv side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Rectiv: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a light-headed feeling, like you might pass out.
Common Rectiv side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Rectiv?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Rectiv, especially:
aspirin or heparin;
blood pressure medication;
ergot medicine - dihydroergotamine, ergotamine, ergonovine, methylergonovine;
medicine to treat a blood clot - alteplase, streptokinase, urokinase, tenecteplase); or
nitroglycerin used in a pill form or spray under the tongue, or as a skin patch or skin ointment.
This list is not complete. Other drugs may interact with nitroglycerin rectal, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 3.01.
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- Drug class: antianginal agents