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User Reviews for Nitroglycerin to treat Anal Fissure and Fistula

Also known as: Nitrostat, Nitro-Dur, Nitro-Bid, Rectiv, Nitrolingual Pumpspray, Nitrostat Tablets, Minitran, NitroMist Nitro-Time Deponit Nitro TD Patch-A GoNitro …show all brand names

Nitroglycerin has an average rating of 7.3 out of 10 from a total of 33 ratings for the treatment of Anal Fissure and Fistula. 64% of reviewers reported a positive effect, while 15% reported a negative effect.

Nitroglycerin Rating Summary

7.3/10 average rating

33 ratings from 33 user reviews.

Compare all 2 medications used in the treatment of Anal Fissure and Fistula.

10
24%
9
15%
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24%
7
18%
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3%
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Reviews for Nitroglycerin

JustAGuy · Taken for less than 1 month February 13, 2020

Rectiv (nitroglycerin): “Dealt with anal fissures for multiple years. Lived in 24/7 anxiety. Spent countless hours researching the internet for solutions. Felt like I was becoming as knowledgeable as a colorectal surgeon. First couple of times I tried Rectiv, the headaches were INSANE. Very intense. To the point I quit taking. I started up again and dealt with it and after a couple of days, the headaches went away—as did my symptoms. The .4% nitro solution can be made into a .2% compound at a speciality pharmacy — which will ease the headaches. (And only cost $17!!) Bottom line is: the stuff works.”

9 / 10
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Bill Durham · Taken for less than 1 month January 12, 2020

Rectiv (nitroglycerin): “Suffered excruciating butt pain on and off over the last year. The anticipation of another bowel movement caused great anxiety. Tried diet change and fiber supplements. Started applying Rectiv three days ago. On my fourth day. All pain has subsided. Very slight “tingle” in my head when initially used each time. Wouldn’t consider it a headache, but more of an indication the medication was taking effect. Dr. prescribed the day before I was leaving for vacation to the Keys. Writing this on the beach - pain free.”

10 / 10
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JL May 10, 2021

Rectiv (nitroglycerin): “After countless visits to the doctor, an emergency room physician figured out I had a fissure and not hemorrhoids. For the side effect of headache? Take some Advil and drink some water and it doesn’t even hurt anymore. This medication works. In the three days I’ve been using it, my pain has reduced substantially and my bleeding has stopped.”

9 / 10
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Ameyls May 31, 2017

Rectiv (nitroglycerin): “I struggled with intense pain and bleeding due to a fissure for several months. Assuming it was hemmorhoids, I tried multiple over the counter medicines, but nothing worked. My OB/Gyn was the one who realized it was a fissure and prescribed Rectiv. The headaches were rough at first, and I almost quit using the ointment because of them. I'm so glad I didn't, though. Within one week, the headaches were gone, and my fissure symptoms were calming down. By week two, I was totally back to normal--no pain, no bleeding. I continued using it for another week, just to be sure I was completely healed. I've been off it for two weeks now, and I'm still symptom-free. I can't sing the praises of this medicine enough!!”

9 / 10
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Relief · Taken for less than 1 month September 4, 2018

Rectiv (nitroglycerin): “I suffered for over a year with a anal fissure that was so painful I’d lay in the bath 3-4 times a day to get relief. It was also infected and was leaking a horrible smelly clear discharge. I finally went to the doctor and had it checked out. He prescribed this to see if it would work and within a couple weeks I was healed and had 0 pain. The headaches only last a week or less from the first use. This stuff is amazing and I can’t praise it enough. I thought I was gonna have to deal with the excruciating pain for forever.”

10 / 10
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Fissureman · Taken for less than 1 month June 10, 2021

Rectiv (nitroglycerin): “My advice is to take 2 tylenol extra strength or, ibuprofen 15 min before applying nitroglycerin ointment to the anal area, this will help with the headache that you will get. Use a (small dab) -like on a cotton swab- and apply to the "outside" of the anus. Inside application and your asking for a "tear your head apart headache".... Do this at night when you are home for the day. I wouldn't advise using this before or during the work day. Because you can experience a back of the head migraine for around 1-2 hours. And you more than likely won't make it through the work day.”

7 / 10
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Ughhhh · Taken for less than 1 month April 18, 2020

Rectiv (nitroglycerin): “Worst headache ever instantly after application of Rectiv. It does alleviate the rectal hell I've experienced. I am miserable and I'm just praying this heals. I DON'T KNOW HOW MUCH LONGER I CAN DO THE FISSURE OR THIS MEDICATION.”

5 / 10
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Frequently asked questions

AP · Taken for less than 1 month April 28, 2020

Rectiv (nitroglycerin): “I've been using this ointment for three days now and just started noticing that bowel movements are less painful. The headache side-effect is a real thing but for me, isn't strong and only lasts for about 20-30 minutes. It does happen every single time though and it's almost instant. My insurance did cover this but I still paid $80.00 for one tube.”

7 / 10
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Bear Man · Taken for less than 1 month August 24, 2015

Rectiv (nitroglycerin): “I developed anal fissures after using Invokamet and Invokana. My GI Dr. prescribed Rectiv to heal them. It worked! However, I got an instant Migraine each time. You cannot take aspirin, so I took my Migraine medicine - Fiorcet. It took about two weeks to heal. A real godsend! Only downfall was the cost - $525.00 per tube. Insurance covered it, thankfully!”

8 / 10
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RN · Taken for less than 1 month August 15, 2019

“Im a GI nurse and I was in so much pain, tried to self manage thinking it was only hemorrhoids but in fact I had a good size fissure and was prescribed this. Yes it is expensive I was almost tempted to leave it at the pharmacy but I decided that I needed to just take care of the issue. First dose was scary, I had palpations, I was sweating and I instantly got a headache. For my second dose I used a little less (pea sized) and it was okay. Yes there is a headache but it went away within an hour. I’m on day 3 and I’m already seeing an improvement. I don’t think I would use it for 3 weeks like I was prescribed but yes meds work. FYI, use gloves when handling this med.”

7 / 10
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Julie March 23, 2018

Rectiv (nitroglycerin): “This is a fantastic medication.I was trying everything over the counter and nothing really helped till my doctor put me on rectiv. I thank god for this medication and my doctor for prescribing it. Within 3 days of use the pain subsided and I felt a major difference. I'm back to my old self again ”

10 / 10
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scaredy cat · Taken for less than 1 month January 27, 2021

Rectiv (nitroglycerin): “This medicine sat on my shelf for over 6 months - I was so afraid of the 'worst headache ever' described in many posts. I finally became desperate enough to use it, and am on 5th day now. Please don't be afraid to try this. It has absolutely helped the fissure. No pain or blood the last 3 days (after over 1 year of pain and bleeding). Every application I do get an unpleasant pressure sensation in my head immediately (which is creepy), but it does go away in an hour. Only once was it a full on headache and I think I used too much of the product. But not even so bad of headache that I took tylenol or advil for it. Be very careful to only apply the 1 inch amount. The product does burn my skin a bit - I suspect the PEG or lanolin ingredients. If I ever need it again I would ask about a compounding pharmacy preparing a hypo-allergenic version. I am F, 5'7 weight 120. I am usually very sensitive to medicines and often choose pediatric dosed of products.”

9 / 10
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AL54 · Taken for less than 1 month July 22, 2020

“This part of the Leaflet my hospital NHS gave me • About 60-70% people with a chronic anal fissure are cured with a 6-8 week course of GTN. Therefore, the chance of a cure by using GTN is better than with the supportive method alone • You should rub a pea size amount of the ointment into the skin around the rim of the anus 2-3 times a day. Do not push it inside the anus. If you do, it will be absorbed into the blood stream 3 and you are more likely to get side effects, such as a headache • It is important that you complete the full course of treatment, as it may take 6-8 weeks of treatment for the fissure to heal fully. However symptoms such as pain may ease quickly Hope it helps guys and girls”

8 / 10
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MK · Taken for 1 to 6 months August 20, 2018

“I have had a fissure for a months now. Thinking it was a hemorrhoid I tried to treat it myself. Unfortunately for me the pain go worse one day and was SO bad I had to go to the ER. Just so they could prescribe me some kind of pain killer.....which they didn't do. Fast forward two weeks and I have an appointment with a specialist. He applies the cream for inspection and just that small amount for the digital exam was enough to give me almost INSTANT pain relief. Instant as in a few minutes later the pain was bearable enough where I could sit and sleep. If you are having symptoms of hemorrhoids just go in and get your body checked out. I was in high school when I got my first one and did not have any kind of rectal exam due to embarrassment until I was 25. Don't be me. Get an exam and get relief. and get it fixed Just don't go to a crappy ER like I did.”

10 / 10
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tnurse March 10, 2014

Rectiv (nitroglycerin): “I'm on day 2 of this product and I "feel" a drastic difference. I am forever grateful to my doctor for prescribing this. 3 years ago I had the same issue and I suffered for 3 months with excruciating pain during my bowel movement to the point I added to my misery by holding it for up to a week at a time to suffer from as few painful bowel motions as possible all because I was to embarrassed to show this problem to my doctor. Never again and I really thank the pharmacist for the coupon to bring my cost down to 40 dollars. There is a mild side effect I didn't have a headache more so painless throbbing in my head for the first 1-2 after application. I was still able to function and get through my clinicals without feeling faint or ill.”

9 / 10
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Mfish January 23, 2020

Rectiv (nitroglycerin): “I have never had such a severe headache in my life. Made the mistake of using before bed. Headache kept me up all night into the morning finally had to take caffeine pills to try to constrict the blood vessels in my head. I will NEVER use this again. Rather have pain my my butt the feel like my head is being ripped apart.”

1 / 10
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Cb April 25, 2019

Rectiv (nitroglycerin): “Tried this cream (Rectiv) once and I had a severe headache. Not knowing it was the cause I tried the second dose and I had an excruciating headache that not even pain killers could take away. Didn’t take it again...”

1 / 10
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AF · Taken for 1 to 6 months July 21, 2021

Rectiv (nitroglycerin): “I developed a fissure just before the pandemic and was only able to get a virtual appointment. I was prescribed Rectiv and it did provide relief. I experienced a dull, but unpleasant headache for a couple of weeks before I adjusted and the headaches improved and eventually went away. It did help with pain relief and some healing, but the fissure never healed and I ended up having a surgical procedure to repair it.”

7 / 10
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Lee September 3, 2018

“I have gone to my new surgeon she had done a colonoscopy on me. After that went to the follow up she said I have a really bad fissure tear with hemorrhoids so she gave me this medicine. She said it will make you dizzy, headaches or even fall down I am 24 years old I have had this pain for almost 2-3 years with blood in my stool. She even put me on a high fiber diet, I am now taking stool softeners and Metamucil. So she said start with a pea size then a inch pea size 1-3 times a day. If you can and start with 1 inch 12 hours a day then do a other pea size if you took a shower or a bowel movement. Side effects I had. Weakness, headaches, little,dizzy lets see the results when I go back to the surgeon I hope no surgery. But once I got used to it I barely had headaches. Mild after a month and a half of using cannot remember.”

8 / 10
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Mrnoone · Taken for less than 1 month May 23, 2021

“Hi. Had fissure for 18 months due to chronic ideopathic constipation. I used to bleed every time I had a bowel motion and had severe pain.. I was on this before but it didn't work so trying once more other wise ill need botox injection. Anyway Ive been on it for over a week and yes had slight headache and been very dizzy. I still am getting pain but so far no bleeding!! I will continue for 7-11 weeks, fingers crossed for yall.. I'm 5'2 & 100lbs.. 24..BTW”

8 / 10
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masterofnone3 December 8, 2016

“Had bleeding fissure for several years. nitrogylerine mixture healed it within two days. As the doctor suggested, I continued to use for a month. I do not know if it will be a permanent fix. I did get headaches from it. Wasn't too bad though and given it worked... BTW, my doctor had a compounding pharmacy create the mixture. It cost $22 for year's supply. I noticed a prescription equivalent like Rectiv costs around $500. Thanks doctor!”

10 / 10
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amaan911 · Taken for less than 1 month April 12, 2015

“The best magic medication for fissure pain. I was suffering for 3 months was in severe pain and was getting mentally frustrated, but jst after twice use all pain vanished, Really amazing product ,bear headache and use paracetomol to counter it”

10 / 10
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RMS_10011 March 10, 2017

Rectiv (nitroglycerin): “I've been on Rectiv for 2 weeks alongside an initial 10-day course of Cipro for a fistula. The Rectiv does cause an immediate headache within minutes of use, but after a few days it goes away, or you get used to it. I did notice relief of pain and swelling for a while until a sudden return of the pain, fistula and swelling! For no apparent reason and after no sudden changes in diet! Seeing my doctor tomorrow to try and determine another angle.”

8 / 10
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masterofnone3 December 5, 2016

“My doctor had a compounding pharmacy make the equivalent for me. Only cost $22. I hear some of the people paying $500 for the prescription type? Anyway, before taking the medicine, I bled everyday. No pain but lots of blood for several years. After about 3 days the bleeding has stopped. As my doctor suggested, I continue to take the medicine for at least one month. Bottom line is that it let the fissure heal. Whether it will begin bleeding again after the medicine is stopped is another question. I hope not.”

10 / 10
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Karen · Taken for less than 1 month October 30, 2021

“A month of laying on my side, unable to move without pain, drinks with Miralax to avoid the pain and I finally got into my gastro. She spotted a fissure immediately. Two days in and the pain is gone. My prescription only requires a pea size portion. The tube, IMO, recommends a ridiculous amount that would give anyone side affects. Ask your doctor, no way would most People require a one inch ribbon like the box says! Thank God Medicare covers this, $785.00 a tube? Big pharma at work… I took an Advil with each dose on day one, no headache.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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