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Pregabalin Dosage

Applies to the following strength(s): 25 mg ; 50 mg ; 75 mg ; 100 mg ; 150 mg ; 200 mg ; 300 mg ; 225 mg ; 20 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetic Neuropathy

-Initial dose: 50 mg orally 3 times a day
-Titration: The dose may be increased to 100 mg orally 3 times a day within 1 week based on efficacy and tolerability
-Maximum dose: 100 mg orally 3 times a day in patients with a creatinine clearance of at least 60 mL/min

Comment:
-This drug may be taken with or without food.

Use: Management of neuropathic pain associated with diabetic peripheral neuropathy

Usual Adult Dose for Postherpetic Neuralgia

-Initial dose: 75 mg orally 2 times a day OR 50 mg orally 3 times a day
-Titration: The dose may be increased to 100 mg orally 3 times a day within 1 week based on efficacy and tolerability
-Maintenance dose: 75 to 150 mg orally 2 times a day OR 50 to 100 mg orally 3 times a day (150 to 300 mg/day) in patients with a creatinine clearance of at least 60 mL/min
-Maximum dose: Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day and who are able to tolerate this drug, may be treated with up to 300 mg orally 2 times a day or 200 mg orally 3 times a day (due to the dose-dependent adverse effects and the higher rate of treatment discontinuation due to adverse events, dosing above 300 mg/day should be reserved only for those patients who have ongoing pain and are tolerating 300 mg daily)

Comment:
-This drug may be taken with or without food.

Use: Management of postherpetic neuralgia

Usual Adult Dose for Epilepsy

-Initial dose: 75 mg orally 2 times a day OR 50 mg orally 3 times a day
-Maintenance dose: 150 mg/day to 600 mg/day (the total daily dose should be divided and given either 2 or 3 times a day)
-Maximum dose: 600 mg/day in 2 or 3 divided doses based on individual patient response and tolerability

Comments:
-This drug may be taken with or without food.
-The efficacy of add-on therapy in patients taking gabapentin has not been evaluated in controlled trials; therefore, dosing recommendations for the use of this combination cannot be offered.

Use: Adjunctive therapy for adult patients with partial onset seizures

Usual Adult Dose for Fibromyalgia

-Initial dose: 75 mg orally 2 times a day (150 mg/day)
-Titration: The dose may be increased to 150 mg orally 2 times a day (300 mg/day) within 1 week based on efficacy and tolerability
-Maintenance dose: 300 to 450 mg/day in 2 divided doses
-Maximum dose: Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg orally 2 times a day (450 mg/day)

Comments:
-This drug may be taken with or without food.

Use: Management of fibromyalgia

Although pregabalin was also studied at 600 mg/day, there is no evidence that this dose confers additional benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 450 mg/day is not recommended.

Usual Adult Dose for Neuropathic Pain

-Initial dose: 75 mg orally 2 times a day
-Titration: The dose may be increased to 150 mg orally 2 times a day within 1 week based on efficacy and tolerability
-Maintenance dose: 150 to 600 mg/day in divided doses
-Maximum dose: Patients who do not experience sufficient pain relief after 2 to 3 weeks of treatment with 150 mg orally 2 times a day and who tolerate this drug may be treated with up to 300 mg orally 2 times a day

Comments:
-This drug may be taken with or without food.

Use: Neuropathic pain associated with spinal cord injury

Renal Dose Adjustments

-CrCl less than 15 mL/min:
Initial dose: 25 mg orally once daily
Maintenance dose: 25 to 75 mg orally once daily
-CrCl 15 to 30 mL/min:
Initial dose: 25 to 50 mg orally per day in 1 to 2 divided doses
Maintenance dose: 25 to 150 mg orally per day in 1 to 2 divided doses
-CrCl 30 to 60 mL/min:
Initial dose: 75 mg orally per day in 2 or 3 divided doses
Maintenance dose: 75 to 300 mg orally per day in 2 to 3 divided doses

For patients undergoing hemodialysis, adjust the daily dose based on renal function; in addition to the daily dose adjustment, administer a supplemental dose immediately following every 4-hour hemodialysis treatment:
-Patients on the 25 mg/day regimen: take one supplemental dose of 25 mg or 50 mg
-Patients on the 25 to 50 mg/day regimen: take one supplemental dose of 50 mg or 75 mg
Patients on the 50 to 75 mg/day regimen: take one supplemental dose of 75 mg or 100 mg
Patients on the 75 mg/day regimen: take one supplemental dose of 100 mg or 150 mg

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule V

Dialysis

For patients undergoing hemodialysis, adjust the daily dose based on renal function; in addition to the daily dose adjustment, administer a supplemental dose immediately following every 4-hour hemodialysis treatment:
-Patients on the 25 mg/day regimen: take one supplemental dose of 25 mg or 50 mg
-Patients on the 25 to 50 mg/day regimen: take one supplemental dose of 50 mg or 75 mg
-Patients on the 50 to 75 mg/day regimen: take one supplemental dose of 75 mg or 100 mg
-Patients on the 75 mg/day regimen: take one supplemental dose of 100 mg or 150 mg

Other Comments

Administration advice:
-This drug may be given with or without food.

General:
-When discontinuing therapy, taper gradually over a minimum of 1 week.

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