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Pregabalin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Pregabalin Qulipta Topamax
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Pregabalin Qulipta (atogepant) Topamax (topiramate)
Prescription only

Pregabalin is used in the treatment of nerve pain and also to prevent seizures. Drowsiness or dizziness are common side effects, and it has the potential to be misused. Prescribed for Neuropathic... View more

Prescription only

Prescribed for Migraine Prevention. Qulipta may also be used for purposes not listed in this medication guide.

Prescription only

Topamax may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraine. Drowsiness is a... View more

More about Pregabalin More about Qulipta (atogepant) More about Topamax (topiramate)
Generic Status

Lower-cost generic is available

No lower-cost generic available

Lower-cost generic is available
Ratings & Reviews

Pregabalin has an average rating of 6.7 out of 10 from a total of 1564 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 25% reported a negative effect.

Qulipta has an average rating of 6.0 out of 10 from a total of 36 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 30% reported a negative effect.

Topamax has an average rating of 6.2 out of 10 from a total of 624 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 30% reported a negative effect.

View all 1564 reviews

View all 36 reviews

View all 624 reviews

Drug Class
Side Effects

Commonly reported side effects include:

  • infection
  • ataxia
  • blurred vision
  • constipation
  • diplopia
  • dizziness
  • drowsiness
  • fatigue
  • headache
  • peripheral edema
  • tremor
  • weight gain
  • visual field loss
  • accidental injury
  • xerostomia
  • show all 15

See also: pregabalin side effects in more detail.

See also: Qulipta side effects in more detail.

Common side effects include:

  • anxiety
  • ataxia
  • confusion
  • diarrhea
  • diplopia
  • dizziness
  • drowsiness
  • dysphasia
  • fatigue
  • lack of concentration
  • memory impairment
  • nausea
  • nervousness
  • paresthesia
  • psychomotor disturbance
  • speech disturbance
  • depression
  • visual disturbance
  • weight loss
  • dysgeusia
  • mood changes
  • anorexia
  • show all 22

See also: Topamax side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Dosage 150 mg
Per Unit* $0.90
Cost* $45.20

View all pregabalin prices

Quantity 30 tablet
Dosage 10 mg
Per Unit* $36.84
Cost* $1,105.20

View all Qulipta prices

Quantity 60 tablet
Dosage 100 mg
Per Unit* $18.97
Cost* $1,137.94

View all Topamax prices and generic prices

Get free Discount Card

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Dosage Form(s) Available
  • Oral capsule
  • Oral solution
  • Oral tablet, extended release
  • Oral tablet
  • Oral tablet
Brand Names
Lyrica, Lyrica CR

N/A

 Other topiramate brands include: Eprontia, Qudexy XR, Trokendi XR
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

6.3 hours

11 hours

56 hours
CSA Schedule ** View glossary of terms
5
Some potential for abuse

Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
Drug Interactions

A total of 280 drugs are known to interact with pregabalin:

  • 27 major drug interactions (144 brand and generic names)
  • 252 moderate drug interactions (1038 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 166 drugs are known to interact with Qulipta:

  • 76 major drug interactions (213 brand and generic names)
  • 5 moderate drug interactions (10 brand and generic names)
  • 85 minor drug interactions (268 brand and generic names)

A total of 285 drugs are known to interact with Topamax:

  • 105 major drug interactions (631 brand and generic names)
  • 177 moderate drug interactions (684 brand and generic names)
  • 3 minor drug interactions (13 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of pregabalin such as dizziness, drowsiness... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Ask your doctor before using alcohol together with topiramate. This can cause excessive sleep... View more
Disease Interactions
First Approval Date

N/A

September 28, 2021

December 24, 1996
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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