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Trokendi XR

Generic name: topiramate (toe PYRE a mate)
Brand name: Trokendi XR
Drug class: Carbonic anhydrase inhibitor anticonvulsants

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jun 14, 2021.

What is Trokendi XR?

Trokendi XR (topiramate) is a seizure medicine, also called an anticonvulsant.

Trokendi XR is used to help prevent certain types of seizures in adults and children who are at least 6 years old.

Trokendi XR is also used to prevent migraine headaches in adults and teenagers who are at least 12 years old. Topiramate will only prevent migraine headaches or reduce the number of attacks. It will not treat a headache that has already begun.

Warnings

Trokendi XR may cause vision problems that can be permanent if not treated quickly. Call your doctor right away if you have a sudden decrease in vision.

Trokendi XR may increase the risk of a birth defect called cleft lip and palate in a newborn. There may be other medications that are safer to use during pregnancy. Tell your doctor right away if you become pregnant.

Trokendi XR can increase body temperature and decrease sweating, which may lead to life-threatening dehydration. Tell your doctor if you have decreased sweating, high fever, and hot dry skin.

Trokendi XR can also increase the level of acid in your blood (metabolic acidosis). Tell your doctor if you have irregular heartbeats, shortness of breath, loss of appetite, or trouble thinking.

Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Do not stop using Trokendi XR suddenly or you could have increased seizures.

Before taking this medicine

You should not use Trokendi XR if you are allergic to topiramate. Do not take Trokendi XR within 6 hours before or 6 hours after drinking alcohol.

Tell your doctor if you are sick with diarrhea, or if you have ever had:

  • glaucoma or other eye problems;

  • metabolic acidosis (high levels of acid in your blood);

  • kidney disease, kidney stones, or dialysis;

  • lung disease, breathing problems;

  • mood problems, depression, or suicidal thoughts or actions;

  • liver disease;

  • a growth disorder; or

  • soft or brittle bones (osteoporosis, osteomalacia).

Topiramate can increase the level of acid in your blood (metabolic acidosis). This can weaken your bones, cause kidney stones, or cause growth problems in children or harm to an unborn baby. You may need blood tests to make sure you do not have metabolic acidosis, especially if you are pregnant.

Some people have thoughts about suicide while taking an anticonvulsant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking Trokendi XR during pregnancy may increase the risk of cleft lip and/or cleft palate, a birth defect that can develop early in pregnancy even before you know you are pregnant. However, having a seizure during pregnancy could harm both the mother and the baby. Tell your doctor right away if you become pregnant.

If you take Trokendi XR during pregnancy: The benefit of preventing seizures may outweigh any risks posed by this medicine. There may be other medications that are safer to use. Do not start or stop taking Trokendi XR without your doctor's advice.

If you are not pregnant or planning to become pregnant, use effective birth control to prevent pregnancy while taking topiramate.

Topiramate can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy.

It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks.

How should I take Trokendi XR?

Take Trokendi XR exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Trokendi XR can be taken with or without food.

Swallow the tablet whole and do not crush, chew, or break it. The Trokendi XR extended-release capsule must be swallowed whole. Do not break or open.

Carefully follow the swallowing instructions for your medicine.

Topiramate doses are sometimes based on weight in children. Your child's dose needs may change if the child gains or loses weight.

Drink plenty of liquids while you are taking Trokendi XR, to prevent kidney stones or an electrolyte imbalance.

You will need frequent medical tests. If you need surgery, tell the surgeon ahead of time that you are using topiramate. Any medical care provider who treats you should know that you take seizure medication.

Do not stop using Trokendi XR suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.

Call your doctor if your seizures get worse or you have them more often while taking Trokendi XR.

Store at cool room temperature away from moisture, light, and high heat.

What happens if I miss a dose?

Take the medicine as soon as you can. Do not take two doses at one time.

Call your doctor if you have missed more than one dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of topiramate can be fatal. Overdose can cause drowsiness, agitation, depression, double vision, thinking problems, problems with speech or coordination, fainting, and seizure (convulsions).

What to avoid

Do not drink alcohol. Dangerous side effects or increased seizures may occur.

Avoid becoming overheated or dehydrated in hot weather. Topiramate can increase body temperature and decrease sweating, leading to life-threatening dehydration (especially in children).

Avoid the use of a ketogenic or "ketosis" diet (high in fat, low in carbohydrates) while you are taking Trokendi XR.

Topiramate may cause blurred vision or impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you.

Also avoid activities that could be dangerous if you have an unexpected seizure, such as swimming or climbing in high places.

Trokendi XR side effects

Get emergency medical help if you have signs of an allergic reaction to Trokendi XR (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening mood symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • a skin rash, no matter how mild;

  • vision problems, blurred vision, eye pain or redness, sudden vision loss (can be permanent if not treated quickly);

  • confusion, problems with thinking or memory, trouble concentrating, problems with speech;

  • dehydration symptoms - decreased sweating, high fever, hot and dry skin;

  • signs of a kidney stone - severe pain in your side or lower back, painful or difficult urination;

  • signs of too much acid in your blood - irregular heartbeats, feeling tired, loss of appetite, trouble thinking, feeling short of breath; or

  • signs of too much ammonia in your blood - vomiting, unexplained weakness, feeling like you might pass out.

Common Trokendi XR side effects may include:

  • dizziness, drowsiness, tired feeling, slow reactions;

  • problems with speech or memory;

  • abnormal vision;

  • numbness or tingling in your arms and legs, decreased sensation (especially in the skin);

  • changes in your sense of taste;

  • feeling nervous;

  • nausea, diarrhea, stomach pain, loss of appetite;

  • fever, weight loss; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Trokendi XR?

Using Trokendi XR with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or depression.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with topiramate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Yes, topiramate (Topamax) has been shown to cause weight loss when used for both seizure control and migraine prevention. Topiramate by itself is not specifically approved by the FDA for weight loss, but is used in an "off-label" fashion for this condition. Qsymia, an extended-release medicine that contains phentermine and topiramate, is FDA approved for weight loss, along with diet and exercise. Continue reading

Yes, topiramate, the active ingredient in Trokendi XR has been shown to cause hair loss (alopecia) in clinical studies, but it is not a common side effect. Alopecia with topiramate has been reported in 1% to 4% of children ages 6 to 16 years of age, and in 3% to 4% of patients older than 16 years of age. Trokendi XR is an extended-release form of topiramate. Continue reading

Yes, topiramate has been shown to cause hair loss in studies, but it is not a common side effect. Hair loss (also called alopecia) has been reported in 1% to 4% of children ages 6 to 16 years of age, and in 3% to 4% of patients older than 16 years of age. Higher daily doses (400 mg/day) of topiramate were associated with greater rates of hair loss than lower doses (50 mg/day) in both age groups. Continue reading

It may take 8 to 12 weeks for you to see the full effect of Topamax on your migraine headaches. In clinical studies, some people had fewer headaches after 4 weeks of treatment. In the treatment of epilepsy, Topamax is also started slowly and the dose is increased over a 6-week period. Continue reading

You can usually stay on Topamax (topiramate) to help prevent your migraine headaches as long as the treatment is needed and remains safe for you. You and your doctor will decide how long you stay on treatment. This will be based on how well it is working for you and any side effects you may experience. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trokendi XR only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.