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Trokendi XR

Generic Name: topiramate (toe PYRE a mate)
Brand Names: Trokendi XR

Medically reviewed on Nov 26, 2018

What is Trokendi XR?

Trokendi XR (topiramate) is a seizure medicine, also called an anticonvulsant.

Trokendi XR is used to help prevent certain types of seizures in adults and children who are at least 6 years old.

Trokendi XR is also used to prevent migraine headaches in adults and teenagers who are at least 12 years old. Topiramate will only prevent migraine headaches or reduce the number of attacks. It will not treat a headache that has already begun.

Important Information

Trokendi XR may cause vision problems that can be permanent if not treated quickly. Call your doctor right away if you have a sudden decrease in vision.

Trokendi XR can decrease sweating and may cause life-threatening dehydration (especially in children). Avoid becoming overheated or dehydrated. Tell your doctor if you have decreased sweating, high fever, and hot dry skin.

Do not take Trokendi XR within 6 hours of drinking alcohol.

Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Do not stop using Trokendi XR suddenly or you could have increased seizures.

Before taking this medicine

You should not use Trokendi XR if you are allergic to topiramate. Do not take Trokendi XR within 6 hours before or 6 hours after drinking alcohol. You should not use extended-release Trokendi XR if you have metabolic acidosis (high levels of acid in your blood) and are also taking metformin for diabetes.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

Topiramate can increase the level of acid in your blood (metabolic acidosis). This can weaken your bones, cause kidney stones, or cause growth problems in children or harm to an unborn baby. You may need blood tests to make sure you do not have metabolic acidosis, especially if you are pregnant.

Some people have thoughts about suicide while taking an anticonvulsant. Your doctor will need to check your progress at regular visits while you are using Trokendi XR. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop taking Trokendi XR during pregnancy without your doctor's advice. Topiramate may increase the risk of low birth weight and cleft lip and/or cleft palate in a newborn. There may be other seizure medicine that can be more safely used during pregnancy. Tell your doctor right away if you become pregnant.

Trokendi XR can make birth control pills less effective. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy while taking Trokendi XR.

Topiramate can pass into breast milk. It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks. Tell your doctor if you are breast-feeding.

How should I take Trokendi XR?

Take Trokendi XR max exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Trokendi XR can be taken before, during, or after a meal.

The Trokendi XR extended-release capsule must be swallowed whole. Do not break open a capsule and sprinkle the contents on food. Do not crush or chew a capsule.

While using topiramate, you may need frequent blood tests. If you need surgery, tell the surgeon ahead of time that you are using topiramate. Any medical care provider who treats you should know that you take seizure medication.

Topiramate doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

Drink plenty of liquids while you are taking topiramate, to prevent kidney stones or an electrolyte imbalance.

Do not stop using Trokendi XR suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.

Call your doctor if your seizures get worse or you have them more often while taking Trokendi XR.

Store at cool room temperature away from moisture, light, and high heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if you are more than 6 hours late in taking it. Wait until your next scheduled dose. Do not take extra medicine to make up the missed dose.

Call your doctor for instructions if you miss two or more doses.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, agitation, depression, double vision, thinking problems, problems with speech or coordination, fainting, and seizure (convulsions).

What should I avoid while taking Trokendi XR?

Do not drink alcohol. Dangerous side effects or increased seizures may occur.

Avoid becoming overheated or dehydrated in hot weather. Topiramate can decrease sweating and increase body temperature, leading to life-threatening dehydration (especially in children).

Ketogenic or "ketosis" diets that are high in fat and low in carbohydrates can increase the risk of kidney stones. Avoid the use of such diets while you are taking Trokendi XR.

Topiramate may cause blurred vision or impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you.

Also avoid activities that could be dangerous if you have an unexpected seizure, such as swimming or climbing in high places.

Trokendi XR side effects

Get emergency medical help if you have signs of an allergic reaction to Trokendi XR: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening mood symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • vision problems, eye pain or redness, sudden vision loss (can be permanent if not treated quickly);

  • confusion, problems with thinking or memory, trouble concentrating, problems with speech;

  • dehydration symptoms - decreased sweating, high fever, hot and dry skin;

  • signs of a kidney stone - severe pain in your side or lower back, painful or difficult urination;

  • signs of too much acid in your blood - irregular heartbeats, feeling tired, loss of appetite, trouble thinking, feeling short of breath; or

  • signs of too much ammonia in your blood - vomiting, unexplained weakness, feeling like you might pass out.

Common Trokendi XR side effects may include:

  • fever, weight loss;

  • numbness or tingling in your arms and legs;

  • flushing (warmth, redness, or tingly feeling);

  • headache, dizziness, drowsiness, tired feeling, slow reactions;

  • mood problems, feeling nervous;

  • nausea, diarrhea, stomach pain, loss of appetite, indigestion;

  • cold symptoms such as stuffy nose, sneezing, sore throat; or

  • changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Trokendi XR?

Taking Trokendi XR with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, opioid pain medication, muscle relaxer, or medicine for anxiety or depression.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • birth control pills; or

  • divalproex (Depakote) or valproic acid (Depakene).

This list is not complete. Other drugs may interact with topiramate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trokendi XR only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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