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Trokendi XR (topiramate) Drug Interactions

A total of 638 drugs are known to interact with Trokendi XR (topiramate).

  • 361 major drug interactions
  • 268 moderate drug interactions
  • 9 minor drug interactions

Show all medications in the database that may interact with Trokendi XR (topiramate).

Check for interactions

Type in a drug name to check for interactions with Trokendi XR (topiramate).

Most frequently checked interactions

View interaction reports for Trokendi XR (topiramate) and the medicines listed below.

  • amitriptyline (Elavil, Endep, Vanatrip)
  • caffeine (Vivarin, Caffedrine, Jet Alert Regular Strength, Jet Alert Maximum Strength, Stay Awake, Alert, Diurex Ultra, Valentine, NoDoz, Jet Alert Double Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, Cafcit, 357 HR Magnum, Enerjets, Fastlene, Keep Going, Molie, Overtime)
  • clonazepam (Klonopin, Klonopin Wafer)
  • cyclobenzaprine (Flexeril, Fexmid, Amrix, Comfort Pac with Cyclobenzaprine)
  • Cymbalta (duloxetine)
  • Fioricet (acetaminophen / butalbital / caffeine)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Children's Motrin, Proprinal, Motrin IB, Childrens Ibuprofen Berry, Advil Children's, Ibuprofen PMR, Ibu-8, Rufen, IBU-200, Motrin Childrens, Advil Migraine, Caldolor, Ibu-Tab, Menadol, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Pediatric, Genpril, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, NeoProfen, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Levothyrox, Eltroxin, Euthyrox, Unithroid, Oroxine, Eutroxsig, Levo-T, L Thyroxine Roche, Novothyrox, Levotabs, Tirosint-Sol, Levotec, Evotrox)
  • magnesium oxide (Mag-Ox, Mag-Oxide, Mag-Ox 400, Uro-Mag, Mag-200, MagGel, Phillips' Cramp-free, Mag-Caps)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • phentermine (Adipex-P, Lomaira, Fastin, Suprenza, T-Diet, Teramine, Oby-Cap, Ionamin, Obenix, Atti-Plex P, Pro-Fast HS, Phentercot, Phentride, Obephen, Panshape M, Pro-Fast SR, Zantryl, Oby-Trim, Pro-Fast SA, Teramine ER)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
  • rizatriptan (Maxalt, Maxalt-MLT)
  • Singulair (montelukast)
  • tizanidine (Zanaflex)
  • Topamax (topiramate)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, ConZip, Ultram ER, Zydol, Tramahexal, Zamadol, Ryzolt, Tramal SR, Larapam SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Trokendi XR (topiramate) alcohol/food interactions

There is 1 alcohol/food interaction with Trokendi XR (topiramate)

Trokendi XR (topiramate) disease interactions

There are 9 disease interactions with Trokendi XR (topiramate) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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