Skip to Content

Onfi

Generic Name: clobazam (KLOE ba zam)
Brand Names: Onfi

Medically reviewed on Sep 5, 2018

What is Onfi?

Onfi (clobazam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Clobazam affects chemicals in the brain that may be unbalanced in people with anxiety.

Onfi is a prescription medicine used in combination with other medications to treat seizures caused by Lennox-Gastaut syndrome, a severe form of childhood epilepsy that also causes developmental and behavior problems.

Onfi in for use in patients 2 years of age or older. It is not known if this medicine is safe and effective in children less than 2 years old.

Important Information

Some people have thoughts about suicide while taking Onfi. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Fatal side effects can occur if you use Onfi with opioid medicine, alcohol, or other drugs that cause drowsiness or slow your breathing.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Before taking this medicine

You should not take Onfi if you are allergic to clobazam.

To make sure you can safely take Onfi, tell your doctor if you have:

  • liver or kidney disease;

  • any type of breathing problem or lung disease;

  • depression or suicidal thoughts or behavior;

  • a drug or alcohol addiction; or

  • if you use a narcotic (opioid) medication.

Some people have thoughts about suicide while taking Onfi. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Clobazam may harm an unborn baby, or problems in a newborn. Your baby could also become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor right away if you become pregnant.

Clobazam can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Onfi, and for at least 28 days after your last dose.

Clobazam can pass into breast milk and may cause drowsiness and feeding problems in a nursing baby. Tell your doctor if you are breast-feeding a baby.

Onfi should not be given to a child younger than 2 years old.

How should I take Onfi?

Take Onfi exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Clobazam may be habit-forming. Misuse can cause addiction, overdose, or death. Selling or giving away Onfi is against the law.

You may crush the Onfi tablet and mix the medicine into a spoonful of applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Do not stop using Onfi suddenly, even if you feel fine. Stopping suddenly may cause increased seizures or unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.

Contact your doctor if your seizures get worse or you have them more often while taking Onfi .

Store at room temperature away from moisture and heat.

Keep track of your medicine. Clobazam is a drug of abuse and you should be aware if anyone is using it improperly or without a prescription.

Onfi dosing information

Usual Adult Dose for Lennox-Gastaut Syndrome:

Initial daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight 30 kg or more: 10 mg orally per day
Day 7 total daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight 30 kg or more: 20 mg orally per day
Day 14 daily dose:
-Body weight 30 kg or less: 20 mg orally per day
-Body weight 30 kg or more: 40 mg orally per day

Comments:
-A daily dose greater than 5 mg should be administered in divided doses twice a day.
-Doses should be escalated no more rapidly than weekly.
-Doses should be withdrawn gradually by tapering the total daily dose by 5 to 10 mg on a weekly basis until discontinued.

Use: Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS)

Usual Geriatric Dose for Lennox-Gastaut Syndrome:

Initial dose: 5 mg orally per day
Day 7 total daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight 30 kg or more: 10 mg orally per day
Day 14 daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight 30 kg or more: 20 mg orally per day
Maximum dose:
-Body weight 30 kg or less: 20 mg/day
-Body weight 30 kg or more: 40 mg/day

Comments:
-A daily dose greater than 5 mg should be administered in divided doses twice a day.
-Doses should be escalated no more rapidly than weekly.
-Based on clinical response, maximum doses may be started after 21 days.
-Doses should be withdrawn gradually by tapering the total daily dose by 5 to 10 mg on a weekly basis until discontinued.

Use: Adjunctive treatment of seizures associated with LGS

Usual Pediatric Dose for Lennox-Gastaut Syndrome:

2 years or older:
Initial daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight 30 kg or more: 10 mg orally per day
Day 7 total daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight 30 kg or more: 20 mg orally per day
Day 14 daily dose:
-Body weight 30 kg or less: 20 mg orally per day
-Body weight 30 kg or more: 40 mg orally per day

Comments:
-A daily dose greater than 5 mg should be administered in divided doses twice a day.
-Doses should be escalated no more rapidly than weekly.
-Doses should be withdrawn gradually by tapering the total daily dose by 5 to 10 mg on a weekly basis until discontinued.

Use: Adjunctive treatment of seizures associated with LGS

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of clobazam can be fatal.

What should I avoid while taking Onfi?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Do not drink alcohol. Dangerous side effects could occur.

Onfi side effects

Get emergency medical help if you have signs of an allergic reaction to Onfi: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • confusion, hallucinations;

  • fever, chills, cough with yellow or green mucus, feeling short of breath;

  • severe drowsiness, feeling like you might pass out;

  • weak or shallow breathing;

  • pain or burning when you urinate; or

  • urinating less than usual or not at all.

The sedative effects of Onfi may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Onfi.

Common Onfi side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Onfi?

Taking Onfi with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may inteact with clobazam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Onfi only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide