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What is the difference between Sympazan and Onfi?

Medically reviewed by Judith Stewart, BPharm. Last updated on June 26, 2023.

Both drugs contain clobazam, so what is the difference between them?

Official answer


Sympazan (clobazam) is available an oral film that dissolves when placed on top of the tongue, and Onfi (clobazam) is available as an oral tablet or oral suspension.

Clobazam belongs to the benzodiazepine class of drugs.

The Sympazan and Onfi brands of clobazam are prescription medicines used along with other medicines to treat seizures associated with Lennox-Gastaut syndrome in people 2 years of age or older.

Dosage Forms

Sympazan Onfi
Oral Film: 5 mg, 10 mg and 20 mg Tablet: 10 mg and 20 mg
Oral Suspension: 2.5 mg/mL

Lennox-Gastaut syndrome (LGS) is a severe form of epilepsy that begins in early childhood and is characterized by multiple types of seizures and intellectual disability.

LGS patients may often have difficulty swallowing pills and oral suspensions due to physical, behavioral or cognitive limitations. The Sympazan oral film may be an easier dosage form for LGS patients to use. The berry flavored Sympazan oral film is placed on top of the tongue where it dissolves without the need for liquid.

Generic Availability
Sympazan: There are no approved generic versions of Sympazan.
Onfi: Generic versions of Onfi are available in both tablet and oral suspension dosage forms.

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