Generic Name: amiodarone (oral) (A mi OH da rone)
Brand Name: Cordarone, Pacerone
What is Pacerone (amiodarone)?
Amiodarone affects the rhythm of your heartbeats.
Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular tachycardia or ventricular fibrillation.
Amiodarone is for use only in treating life-threatening heart rhythm disorders. You will receive your first few doses in a hospital setting, where your heart rhythm can be monitored using an electrocardiograph or ECG (sometimes called an EKG).
Amiodarone may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Pacerone (amiodarone)?
Amiodarone is for use only in treating life-threatening heart rhythm disorders.
You should not take this medicine if you are allergic to amiodarone or iodine, or if you have a serious heart condition such as "AV block" (unless you have a pacemaker), a history of slow heart beats, or if your heart cannot pump blood properly.
This medicine can cause dangerous side effects on your liver or your lungs.
Call your doctor at once if you have: chest pain, trouble breathing, upper stomach pain, dark urine, jaundice (yellowing of the skin or eyes), or if you cough up blood.
What should I discuss with my healthcare provider before taking Pacerone (amiodarone)?
You should not use this medicine if you are allergic to amiodarone or iodine, or if you have:
certain serious heart conditions, especially "AV block" (unless you have a pacemaker);
a history of slow heart beats that have caused you to faint; or
if your heart cannot pump blood properly.
Amiodarone can cause dangerous side effects on your heart, liver, lungs, or thyroid.
To make sure amiodarone is safe for you, tell your doctor if you have:
asthma or another lung disorder;
a thyroid disorder;
high or low blood pressure;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
if you have a pacemaker or defibrillator implanted in your chest.
Do not use amiodarone if you are pregnant. Taking amiodarone during pregnancy can harm the unborn baby or cause thyroid problems or abnormal heartbeats after the baby is born. Amiodarone may also affect the child's growth or development (speech, movement, academic skills) later in life. Use effective birth control to prevent pregnancy during treatment.
Amiodarone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Pacerone (amiodarone)?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
If you have been taking another heart rhythm medicine, you may need to gradually stop taking it when you start using amiodarone. Follow your doctor's dosing instructions very carefully.
You may take amiodarone with or without food, but take it the same way each time.
It may take up to 2 weeks before your heart rhythm improves. Keep using the medicine as directed even if you feel well.
While using amiodarone, you will need frequent medical tests and chest x-rays to check your thyroid, vision, lungs, and liver function. Amiodarone can have long lasting effects on your body. You may need medical tests for several months after you stop using this medicine.
If you need surgery (including laser eye surgery), tell the surgeon ahead of time that you are using amiodarone. You may need to stop using the medicine for a short time.
Amiodarone can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using amiodarone.
Store at room temperature away from moisture, heat, and light.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amiodarone can be fatal.
Overdose symptoms may include weakness, slow heart rate, feeling light-headed, or loss of consciousness.
What should I avoid while taking Pacerone (amiodarone)?
Grapefruit and grapefruit juice may interact with amiodarone and lead to unwanted side effects. Avoid the use of grapefruit products while taking amiodarone.
Avoid exposure to sunlight or tanning beds. Amiodarone can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Pacerone (amiodarone) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Amiodarone takes a long time to completely clear from your body. You may continue to have side effects from amiodarone after you stop using it. It could take up to several months for the medicine to completely clear from your body.
Call your doctor at once if you have any of these side effects, even if they occur up to several months after you stop using amiodarone:
wheezing, cough, chest pain, coughing up blood, breathing problems that get worse;
a new or a worsening irregular heartbeat pattern (fast, slow, or pounding heartbeats);
a light-headed feeling, like you might pass out;
blurred vision, vision loss, headache or pain behind your eyes, sometimes with vomiting;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
signs of overactive thyroid--weight loss, thinning hair, feeling too hot or too cold, increased sweating, irregular menstrual periods, swelling in your neck (goiter); or
signs of underactive thyroid--extreme tired feeling, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cold temperatures, weight gain.
Common side effects may include:
dizziness, vision problems, seeing halos around lights;
loss of coordination, feeling weak or tired;
nausea, vomiting, constipation;
numbness or tingling;
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Pacerone (amiodarone)?
Many drugs can interact with amiodarone. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
an antibiotic--azithromycin, ciprofloxacin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine, rifampin, and others;
an antidepressant--amitriptyline, citalopram, desipramine, doxepin, imipramine, nortriptyline, trazodone, and others;
a blood thinner--warfarin, Coumadin, Jantoven;
a diuretic or "water pill";
"statin" cholesterol medicine--atorvastatin, lovastatin, simvastatin, Lipitor, Zocor, Vytorin, and others;
heart or blood pressure medication--digoxin, disopyramide, dofetilide, flecainide, procainamide, propranolol, quinidine, sotalol, verapamil, and many others;
hepatitis C medication--ledipasvir, simeprevir, sofosbuvir, Harvoni, Olysio, Sovaldi;
HIV or AIDS medication--indinavir, nelfinavir, rilpivirine, ritonavir, saquinavir; or
medicine to treat mental illness--chlorpromazine, fluphenazine, haloperidol, lithium, pimozide, promethazine, thioridazine, ziprasidone, and others.
This list is not complete and many other drugs can interact with amiodarone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Amiodarone takes a long time to completely clear from your body, and drug interactions are possible for up to several months after you stop using amiodarone. Talk to your doctor before taking any medication during this time. Keep track of how long it has been since your last dose of amiodarone.
More about Pacerone (amiodarone)
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about amiodarone.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 6.03.
Date modified: November 30, 2016
Last reviewed: May 23, 2016