Generic Name: propafenone (proe PAF e none)
Brand Name: Rythmol, Rythmol SR
What is Rythmol (propafenone)?
Propafenone is in a group of drugs called Class IC anti-arrhythmics. It affects the way your heart beats.
Propafenone is used in certain situations to prevent serious heart rhythm disorders.
Propafenone may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Rythmol (propafenone)?
You should not use this medication if you have untreated or uncontrolled congestive heart failure, a heart condition called "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats or severely low blood pressure, an electrolyte imbalance, a breathing disorder such as asthma, or if you have recently had a heart attack.
Propafenone may cause a new or worsening heartbeat pattern. Call your doctor at once if you have a headache and chest pain with severe dizziness, fainting, and fast or pounding heartbeats.
What should I discuss with my healthcare provider before taking Rythmol (propafenone)?
You should not use propafenone if you are allergic to it, or if you have:
heart failure, or if you have recently had a heart attack;
a genetic heart condition, especially a certain heart rhythm disorder called Brugada syndrome;
a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
severe low blood pressure, or history of slow heart beats that have caused you to faint;
a severe or uncontrolled electrolyte imbalance (such as low levels of potassium in your blood); or
a breathing disorder such as severe COPD (chronic obstructive pulmonary disease).
To make sure propafenone is safe for you, tell your doctor if you have:
heart disease or prior heart attack;
a breathing disorder;
liver or kidney disease;
myasthenia gravis; or
if you have ever had an abnormal blood test called Antinuclear Antibody Test or ANA.
It is not known whether propafenone will harm an unborn baby. Tell your doctor if you are pregnant.
This medicine may affect fertility (ability to have children) in men. Talk with your doctor if you have concerns about this risk.
Propafenone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Rythmol (propafenone)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take propafenone with or without food.
Your heart function may need to be checked with an electrocardiograph or ECG (sometimes called an EKG), before and during treatment with propafenone.
You may have very low blood pressure while taking this medication. Call your doctor if you are sick with vomiting or diarrhea, extreme thirst, loss of appetite, or if you are sweating more than usual.
While using propafenone, you may need frequent blood tests.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Rythmol (propafenone)?
Grapefruit and grapefruit juice may interact with propafenone and lead to unwanted side effects. Avoid the use of grapefruit products while taking propafenone.
Rythmol (propafenone) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
shortness of breath (even with mild exertion), swelling, rapid weight gain;
headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;
confusion, unusual thoughts or behavior;
slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).
Common side effects may include:
nausea, vomiting, constipation;
headache, dizziness, tired feeling; or
unusual or unpleasant taste in your mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Rythmol (propafenone)?
Many drugs can interact with propafenone. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
orlistat (alli, Xenical);
warfarin (Coumadin, Jantoven);
an antibiotic--ciprofloxacin, clarithromycin, enoxacin, telithromycin;
an antidepressant--bupropion (Wellbutrin), fluoxetine (Prozac), paroxetine (Paxil);
antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole;
heart medication--digoxin, nicardipine, lidocaine, quinidine; or
antiviral medicine to treat hepatitis C or HIV/AIDS--atazanavir, boceprevir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.
This list is not complete and many other drugs can interact with propafenone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
More about Rythmol (propafenone)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Español
- 4 Reviews – Add your own review/rating
- Generic Availability
- Drug class: group I antiarrhythmics
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about propafenone.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 9.02.
Date modified: July 24, 2017
Last reviewed: July 19, 2016