Darifenacin Dosage

Medically reviewed by Drugs.com. Last updated on Aug 14, 2023.

Usual Adult Dose for Urinary Incontinence

Initial dose: 7.5 mg orally once a day
Maintenance dose: The dosage may be increased to 15 mg orally once a day as early as 2 weeks after starting therapy

Comments:

• This drug may be taken with or without food.
• The tablet should be swallowed whole with water and not chewed, divided, or crushed.

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency

Usual Adult Dose for Urinary Frequency

Initial dose: 7.5 mg orally once a day
Maintenance dose: The dosage may be increased to 15 mg orally once a day as early as 2 weeks after starting therapy

Comments:

• This drug may be taken with or without food.
• The tablet should be swallowed whole with water and not chewed, divided, or crushed.

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild hepatic impairment (Child Pugh A): No adjustment recommended.
Moderate hepatic impairment (Child Pugh B): Do exceed 7.5 mg daily.
Severe hepatic impairment (Child Pugh C): Not recommended.

Dose Adjustments

Do not exceed 7.5 mg daily when coadministered with potent CYP450 3A4 inhibitors (e.g., ketoconazole, itraconazole, miconazole, nefazodone ritonavir).

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug may be taken with or without food.
• The tablet should be swallowed whole with water and not chewed, divided, or crushed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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