Generic Name: solifenacin (sol ee FEN a sin)
Brand Names: VESIcare
Medically reviewed by Sanjai Sinha, MD. Last updated on Mar 6, 2019.
What is VESIcare?
VESIcare (solifenacin) reduces muscle contractions of the bladder and urinary tract.
VESIcare is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage).
VESIcare may also be used for purposes not listed in this medication guide.
You should not use VESIcare if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate.
Before using VESIcare, tell your doctor if you have glaucoma, liver disease, kidney disease, a blockage in your stomach or intestines, or a history of Long QT syndrome.
Avoid becoming overheated or dehydrated during exercise and in hot weather. VESIcare can decrease perspiration and you may be more prone to heat stroke.
VESIcare may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
Stop using VESIcare and call your doctor if you have serious side effects such as hot and dry skin, extreme thirst, severe stomach pain or constipation, pain or burning when you urinate, or if you stop urinating.
There are many other medicines that can interact with VESIcare. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Before taking this medicine
You should not use VESIcare if you are allergic to solifenacin, or if you have:
untreated or uncontrolled narrow-angle glaucoma;
a stomach disorder causing delayed emptying; or
if you are unable to urinate.
To make sure VESIcare is safe for you, tell your doctor if you have:
trouble emptying your bladder (or you have a weak stream of urine);
a blockage in your stomach or intestines; or
a history of long QT syndrome.
It is not known whether VESIcare will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether solifenacin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using this medicine.
VESIcare is not approved for use by anyone younger than 18 years old.
How should I take VESIcare?
Take VESIcare exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
VESIcare is usually taken once per day with or without food. Follow your doctor's instructions.
Take this medicine with water.
Do not crush, chew, or break the tablet. Swallow it whole.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
VESIcare dosing information
Usual Adult Dose for Urinary Incontinence:
5 mg orally per day.
Usual Adult Dose for Urinary Frequency:
5 mg orally per day.
What happens if I miss a dose?
Take the missed dose on the same day you remember it. Take your next dose at the regular time the next day and stay on your once-daily schedule. Do not take extra medicine to make up the missed dose.
Do not take 2 doses on the same day.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking VESIcare?
Avoid becoming overheated or dehydrated during exercise and in hot weather. Solifenacin can decrease perspiration and you may be more prone to heat stroke.
This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
VESIcare side effects
Get emergency medical help if you have signs of an allergic reaction to VESIcare: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using VESIcare and call your doctor at once if you have:
severe stomach pain, or constipation for 3 days or longer;
pain or burning when you urinate;
vision changes, eye pain, or seeing halos around lights;
little or no urination;
dehydration symptoms - feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
high potassium - nausea, slow or unusual heart rate, weakness, loss of movement; or
severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common VESIcare side effects may include:
pain or burning when you urinate.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect VESIcare?
Many drugs can interact with solifenacin. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
St. John's wort;
an antibiotic - clarithromycin, telithromycin;
antifungal medicine - itraconazole, ketoconazole, posaconazole, voriconazole;
heart or blood pressure medicine - nicardipine, quinidine;
antiviral medicine to treat hepatitis or HIV/AIDS - atazanavir, boceprevir, cobicistat, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir;
seizure medicine - carbamazepine, phenytoin; or
tuberculosis medicine - isoniazid, rifampin.
This list is not complete and many other drugs can interact with solifenacin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use VESIcare only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 4.01.
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- Drug class: urinary antispasmodics