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VESIcare Side Effects

Generic Name: solifenacin

Note: This page contains side effects data for the generic drug solifenacin. It is possible that some of the dosage forms included below may not apply to the brand name VESIcare.

In Summary

Common side effects of VESIcare include: constipation and xerostomia. Other side effects include: urinary tract infection and blurred vision. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to solifenacin: oral tablet

As well as its needed effects, solifenacin (the active ingredient contained in VESIcare) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking solifenacin, check with your doctor immediately:

Less common:
  • Bladder pain
  • bloody or cloudy urine
  • chills
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult, burning, or painful urination
  • difficulty in passing urine (dribbling)
  • fever
  • frequent urge to urinate
  • painful urination
  • swelling of the lower legs
  • unusual tiredness or weakness
Incidence not known:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • fainting
  • irregular heartbeat recurrent
  • irregular or slow heart rate
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • rapid weight gain
  • shortness of breath
  • tingling of the hands or feet
  • unusual weight gain or loss

Minor Side Effects

Some solifenacin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Acid or sour stomach
  • belching
  • body aches or pain
  • congestion
  • cough
  • diarrhea
  • discouragement
  • feeling sad or empty
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • hoarseness
  • indigestion
  • irritability
  • joint pain
  • lack of appetite
  • loss of interest or pleasure
  • lower back or side pain
  • muscle aches and pains
  • nervousness
  • pounding in the ears
  • runny nose
  • shivering
  • slow or fast heartbeat
  • sore throat
  • stomach discomfort, upset, or pain
  • sweating
  • tender, swollen glands in the neck
  • tiredness
  • trouble concentrating
  • trouble with sleeping
  • trouble with swallowing
  • upper abdominal or stomach pain
  • voice changes
Incidence not known:
  • Hives or welts
  • itching
  • redness of the skin
  • skin rash

For Healthcare Professionals

Applies to solifenacin: oral tablet


Very common (10% or more): Dry mouth (up to 28%), constipation (up to 13%)
Common (1% to 10%): Nausea, dyspepsia, upper abdominal pain, vomiting
Uncommon (0.1% to 1%): Gastroesophageal reflux disease, dry throat, flatulence, throat irritation, eructation, thirst
Rare (less than 0.1%): Colonic obstruction, fecal impaction
Postmarketing reports: Ileus[Ref]


Common (1% to 10%): Pharyngitis, cough, sinusitis, bronchitis
Uncommon (0.1% to 1%): Nasal dryness
Postmarketing reports: Dysphonia[Ref]


Common (1% to 10%): Depression
Postmarketing reports: Confusion, hallucinations, delirium, somnolence[Ref]


Common (1% to 10%): Blurred vision, dry eyes
Very rare (less than 0.01%): Glaucoma[Ref]


Common (1% to 10%): Urinary tract infection, urinary retention
Uncommon (0.1% to 1%): Cystitis, suprapubic pain, bladder pain, micturition urgency[Ref]


Common (1% to 10%): Lower limb edema, hypertension
Uncommon (0.1% to 1%): Syncope, chest tightness, hot flushes
Postmarketing reports: Peripheral edema, QT prolongation, Torsade de Pointes, atrial fibrillation, tachycardia, palpitations, atrial fibrillation[Ref]


Uncommon (0.1% to 1%): Dry skin
Rare (0.01% to 0.1%): Pruritus, rash
Very rare (less than 0.01%): Erythema multiforme, urticaria, angioedema, exfoliative dermatitis[Ref]


Common (1% to 10%): Influenza[Ref]


Very rare (less than 0.01%): Decreased appetite, hyperkalemia[Ref]


Very rare (less than 0.01%): Hypersensitivity reactions (including angioedema with airway obstruction, rash, pruritus, urticaria, and anaphylactic reaction)[Ref]


Common (1% to 10%): Fatigue[Ref]


Very rare (less than 0.01%): Renal impairment[Ref]


Postmarketing reports: Abnormal liver function tests, AST (aspartate aminotransferase), ALT (alanine aminotransferase), GGT (gamma-glutamyl transferase)[Ref]


Common (1% to 10%): Arthralgia, back pain
Uncommon (0.1% to 1%): Neck pain
Postmarketing reports: Muscular weakness[Ref]

Nervous system

Common (1% to 10%): Dizziness, insomnia
Uncommon (0.1% to 1%): Dysgeusia
Rare (0.01% to 0.1%): Headache
Postmarketing reports: Headache, tremors[Ref]


1. "Product Information. VESIcare (solifenacin)." GlaxoSmithKline, Research Triangle Park, NC.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of VESIcare may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.