Tolterodine Dosage
Applies to the following strength(s): 1 mg ; 2 mg ; 4 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Urinary Incontinence
Immediate release tablets:
-Initial dose: 2 mg orally 2 times a day
-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability
Extended release capsules:
-Initial dose: 4 mg orally once a day
-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability
Comments:
-This drug can be taken with or without food.
-The extended release formulation should be swallowed whole.
Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency
Usual Adult Dose for Urinary Frequency
Immediate release tablets:
-Initial dose: 2 mg orally 2 times a day
-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability
Extended release capsules:
-Initial dose: 4 mg orally once a day
-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability
Comments:
-This drug can be taken with or without food.
-The extended release formulation should be swallowed whole.
Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency
Renal Dose Adjustments
-Severe renal impairment (CrCl 10 to 30 mL/min):
Tablets: 1 mg orally 2 times a day
Extended release capsules: 2 mg orally once a day
-End stage renal disease (CrCl less than 10 mL/min):
Use is not recommended
Liver Dose Adjustments
-Mild to moderate hepatic impairment (Child-Pugh Class A or B):
Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally 2 times a day
-Severe hepatic impairment (Child-Pugh Class C):
Not recommended
Dose Adjustments
Concomitant use of potent CYP450 3A4 inhibitors:
Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally once a day
Precautions
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-This drug can be taken with or without food.
General:
-Treatment effect should be reevaluated after 2 to 6 months.
