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Tolterodine Dosage

Applies to the following strength(s): 1 mg ; 2 mg ; 4 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Urinary Incontinence

Immediate release tablets:
-Initial dose: 2 mg orally 2 times a day
-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability

Extended release capsules:
-Initial dose: 4 mg orally once a day
-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability

Comments:
-This drug can be taken with or without food.
-The extended release formulation should be swallowed whole.

Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Usual Adult Dose for Urinary Frequency

Immediate release tablets:
-Initial dose: 2 mg orally 2 times a day
-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability

Extended release capsules:
-Initial dose: 4 mg orally once a day
-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability

Comments:
-This drug can be taken with or without food.
-The extended release formulation should be swallowed whole.

Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Renal Dose Adjustments

-Severe renal impairment (CrCl 10 to 30 mL/min):
Tablets: 1 mg orally 2 times a day
Extended release capsules: 2 mg orally once a day
-End stage renal disease (CrCl less than 10 mL/min):
Use is not recommended

Liver Dose Adjustments

-Mild to moderate hepatic impairment (Child-Pugh Class A or B):
Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally 2 times a day
-Severe hepatic impairment (Child-Pugh Class C):
Not recommended

Dose Adjustments

Concomitant use of potent CYP450 3A4 inhibitors:
Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally once a day

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug can be taken with or without food.

General:
-Treatment effect should be reevaluated after 2 to 6 months.

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