Tolterodine Dosage
Medically reviewed by Drugs.com. Last updated on Jul 26, 2021.
Applies to the following strengths: 1 mg; 2 mg; 4 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Urinary Incontinence
Immediate release tablets:
-Initial dose: 2 mg orally 2 times a day
-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability
Extended release capsules:
-Initial dose: 4 mg orally once a day
-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability
Comments:
-This drug can be taken with or without food.
-The extended release formulation should be swallowed whole.
Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency
Usual Adult Dose for Urinary Frequency
Immediate release tablets:
-Initial dose: 2 mg orally 2 times a day
-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability
Extended release capsules:
-Initial dose: 4 mg orally once a day
-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability
Comments:
-This drug can be taken with or without food.
-The extended release formulation should be swallowed whole.
Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency
Renal Dose Adjustments
-Severe renal impairment (CrCl 10 to 30 mL/min):
Tablets: 1 mg orally 2 times a day
Extended release capsules: 2 mg orally once a day
-End stage renal disease (CrCl less than 10 mL/min):
Use is not recommended
Liver Dose Adjustments
-Mild to moderate hepatic impairment (Child-Pugh Class A or B):
Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally 2 times a day
-Severe hepatic impairment (Child-Pugh Class C):
Not recommended
Dose Adjustments
Concomitant use of potent CYP450 3A4 inhibitors:
Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally once a day
Precautions
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-This drug can be taken with or without food.
General:
-Treatment effect should be reevaluated after 2 to 6 months.
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- Tolterodine (Advanced Reading)
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- Tolterodine Extended-Release Capsules
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