Solifenacin Dosage

Medically reviewed by Drugs.com. Last updated on Feb 17, 2025.

Usual Adult Dose for Urinary Incontinence

Initial dose: 5 mg orally once daily
Maintenance dose: 5 to 10 mg orally once daily

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Adult Dose for Urinary Frequency

Initial dose: 5 mg orally once daily
Maintenance dose: 5 to 10 mg orally once daily

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency

Renal Dose Adjustments

• Mild to moderate renal impairment (CrCl greater than 30 mL/min): No adjustment recommended.
• Severe renal impairment (CrCl less than 30 mL/min): Dose should not exceed 5 mg once daily.

Liver Dose Adjustments

• Milk hepatic impairment (Child-Pugh A): No adjustment recommended.
• Moderate hepatic impairment (Child-Pugh B): Dose should not exceed 5 mg once daily.
• Severe hepatic impairment (Child-Pugh C): Not recommended.

Dose Adjustments

Patients taking potent CYP450 3A4 inhibitors (e.g., ketoconazole): Dose should not exceed 5 mg once daily.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or any of the ingredients
• Urinary retention
• Gastric retention
• Uncontrolled narrow-angle glaucoma

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should be swallowed whole with water.
• This drug may be taken with or without food.

Storage requirements:

• Store at 20C to 25C (68F to 77F).
• Protect from light.

Patient advice:

• This drug can cause constipation and blurred vision. Exercise caution when engaging in potentially dangerous activities until the drug's effect on your vision has been determined.
• Contact your healthcare provider if you experience severe abdominal pain or become constipated for 3 or more days.
• Heat prostration (due to decreased sweating) can occur when anticholinergic drugs, such as this drug, are used in a hot environment.
• Promptly discontinue this drug and seek immediate attention if you experience edema of the tongue or laryngopharynx, or difficulty breathing.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer