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Solifenacin Dosage

Medically reviewed by Drugs.com. Last updated on May 10, 2019.

Applies to the following strengths: 5 mg; 10 mg

Usual Adult Dose for Urinary Incontinence

Initial dose: 5 mg orally once daily
Maintenance dose: 5 to 10 mg orally once daily

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Adult Dose for Urinary Frequency

Initial dose: 5 mg orally once daily
Maintenance dose: 5 to 10 mg orally once daily

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency

Renal Dose Adjustments

-Mild to moderate renal impairment (CrCl greater than 30 mL/min): No adjustment recommended.
-Severe renal impairment (CrCl less than 30 mL/min): Dose should not exceed 5 mg once daily.

Liver Dose Adjustments

-Milk hepatic impairment (Child-Pugh A): No adjustment recommended.
-Moderate hepatic impairment (Child-Pugh B): Dose should not exceed 5 mg once daily.
-Severe hepatic impairment (Child-Pugh C): Not recommended.

Dose Adjustments

Patients taking potent CYP450 3A4 inhibitors (e.g., ketoconazole): Dose should not exceed 5 mg once daily.

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-Urinary retention
-Gastric retention
-Uncontrolled narrow-angle glaucoma

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug should be swallowed whole with water.
-This drug may be taken with or without food.

Storage requirements:
-Store at 20C to 25C (68F to 77F).
-Protect from light.

Patient advice:
-This drug can cause constipation and blurred vision. Exercise caution when engaging in potentially dangerous activities until the drug's effect on your vision has been determined.
-Contact your healthcare provider if you experience severe abdominal pain or become constipated for 3 or more days.
-Heat prostration (due to decreased sweating) can occur when anticholinergic drugs, such as this drug, are used in a hot environment.
-Promptly discontinue this drug and seek immediate attention if you experience edema of the tongue or laryngopharynx, or difficulty breathing.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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