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Medications for Neurogenic Detrusor Overactivity

Other names: NDO

About Neurogenic Detrusor Overactivity

Neurogenic Detrusor Overactivity (NDO) is a type of bladder dysfunction that occurs when the spinal cord and bladder are not able to communicate effectively. It most often occurs in patients with neurologic conditions such as transverse myelitis, spina bifida, multiple sclerosis (MS) and spinal cord injuries.

Neurogenic detrusor overactivity is characterized by involuntary contractions of the bladder, which causes increased pressure in the bladder and reduced bladder capacity.

Patients with neurogenic detrusor overactivity experience frequent and unexpected urine leakage. Elevated bladder pressure can also lead to bladder and kidney damage over time.

Treatments for neurogenic detrusor overactivity include medications have been used to reduce detrusor storage pressure, increase bladder capacity, and improve urinary incontinence. The most commonly used medications are antimuscarinics, beta-3 adrenergic agonists, and botulinum neurotoxin.

Drugs used to treat Neurogenic Detrusor Overactivity

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Botox Rate Add review
Rx C N

Generic name: onabotulinumtoxinA systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Ditropan XL Rate Add review
Rx B N X

Generic name: oxybutynin systemic

Drug class: urinary antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

oxybutynin Rate Add review
Rx/OTC B N X

Generic name: oxybutynin systemic

Brand name:  Ditropan XL

Drug class: urinary antispasmodics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

mirabegron Rate Add review
Rx C N

Generic name: mirabegron systemic

Brand name:  Myrbetriq

Drug class: urinary antispasmodics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Myrbetriq Rate Add review
Rx C N

Generic name: mirabegron systemic

Drug class: urinary antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

solifenacin Rate Add review
Rx C N

Generic name: solifenacin systemic

Brand name:  VESIcare LS

Drug class: urinary antispasmodics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

VESIcare LS Rate Add review
Rx C N

Generic name: solifenacin systemic

Drug class: urinary antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

onabotulinumtoxinA Rate Add review
Rx C N

Generic name: onabotulinumtoxinA systemic

Brand name:  Botox

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Learn more about Neurogenic Detrusor Overactivity

IBM Watson Micromedex

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.