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Mirabegron Dosage

Medically reviewed on September 11, 2017.

Applies to the following strengths: 25 mg; 50 mg

Usual Adult Dose for Urinary Incontinence

-Initial dose: 25 mg orally once a day
-Maintenance dose: 25 to 50 mg orally once a day based on individual patient efficacy and tolerability

Comments:
-This drug may be taken with or without food.
-Tablets should be taken with water, swallowed whole, and should not be chewed, divided, or crushed.

Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Adult Dose for Urinary Frequency

-Initial dose: 25 mg orally once a day
-Maintenance dose: 25 to 50 mg orally once a day based on individual patient efficacy and tolerability

Comments:
-This drug may be taken with or without food.
-Tablets should be taken with water, swallowed whole, and should not be chewed, divided, or crushed.

Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Renal Dose Adjustments

-Mild to moderate renal impairment (CrCl 30 to 89 mL/min): No adjustment recommended
-Severe renal impairment (CrCl 15 to 29 mL/min): Dose should not exceed 25 mg a day
-End stage renal disease (CrCl less than 15 mL/min): Not recommended

Liver Dose Adjustments

-Mild hepatic impairment (Child-Pugh A): No adjustment recommended
-Moderate hepatic impairment (Child-Pugh B): Dose should not exceed 25 mg a day
-Severe hepatic impairment (Child-Pugh C): Not recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: Not recommended
Peritoneal dialysis: Data not available

Other Comments

Administration advice:
-This drug may be taken without regard to meals.
-This drug should be taken with water, swallowed whole and should not be chewed, divided, or crushed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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