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Oxybutynin Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 26, 2024.

Applies to oxybutynin: oral syrup, oral tablet, oral tablet extended release.

Other dosage forms:

Precautions

It is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to use it.

This medicine may cause a serious type of allergic reaction called angioedema. Angioedema may be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash, itching, a large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, trouble breathing, or chest tightness while you are using this medicine.

Oxybutynin may cause anxiety, confusion, irritability, sleepiness or unusual drowsiness, or hallucinations (seeing, hearing, or feeling things that are not there). These symptoms are more likely to occur when you begin taking this medicine, or when the dose is increased. If you or your child have these symptoms, tell your doctor right away.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you or your child are using this medicine.

This medicine may cause your eyes to become more sensitive to light than they are normally. Wearing sunglasses and avoiding too much exposure to bright light may help lessen the discomfort.

This medicine may cause some people to become dizzy, drowsy, or have blurred vision. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, not alert, or not able to see well.

Oxybutynin may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you or your child are taking this medicine, since overheating may result in heat stroke. Also, hot baths or saunas may make you feel dizzy or faint while you or your child are taking this medicine.

Your mouth, nose, and throat may feel very dry while you or your child are taking this medicine. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of oxybutynin

Some side effects of oxybutynin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • acid or sour stomach
  • belching
  • decreased sweating
  • diarrhea
  • difficulty having a bowel movement (stool)
  • drowsiness
  • dryness of the eyes, mouth, nose, or throat
  • heartburn
  • indigestion
  • runny nose
  • stomach discomfort, upset, or pain

Less common or rare side effects

  • blurred vision
  • decreased flow of breast milk
  • decreased sexual ability
  • difficulty in swallowing
  • feeling of warmth or heat
  • headache
  • increased sensitivity of the eyes to light
  • nausea or vomiting
  • trouble with sleeping
  • unusual tiredness or weakness

Incidence not known

- Observed during clinical practice with oxybutynin; estimates of frequency cannot be determined
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss

Serious side effects of oxybutynin

Along with its needed effects, oxybutynin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxybutynin:

Rare side effects

  • eye pain
  • skin rash or hives

Get emergency help immediately if any of the following symptoms of overdose occur while taking oxybutynin:

Symptoms of overdose

For healthcare professionals

Applies to oxybutynin: oral solution, oral syrup, oral tablet, oral tablet extended release, transdermal film extended release, transdermal gel.

General adverse events

The most common (incidence 5% or greater) adverse reactions were dry mouth, constipation, diarrhea, headache, somnolence, and dizziness.[Ref]

Cardiovascular

Dermatologic

Endocrine

Gastrointestinal

Hypersensitivity

Genitourinary

Immunologic

Local

Metabolic

Musculoskeletal

Nervous system

Ocular

Other

Psychiatric

Respiratory

Other

Concomitant use of oxybutynin with carbamazepine and dantrolene has been associated with adverse events suggestive of carbamazepine toxicity, such as vomiting, drowsiness, confusion, unsteadiness, slurred speech, and nystagmus.

See also:

References

1. (2001) "Product Information. Ditropan (oxybutynin)." Hoechst Marion Roussel

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Pharmaceutical Society of Australia (2006) APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp

Further information

Oxybutynin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.