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User Reviews for Zoloft to treat Depression

The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Zoloft Rating Summary

User Ratings
24% (122)
20% (102)
14% (70)
10% (48)
4% (19)
4% (21)
4% (19)
4% (18)
5% (27)
12% (59)
6.9/10 Average Rating
505 ratings from 542 user reviews

Compare all 191 medications used in the treatment of Depression.

Reviews for Zoloft

IBS/Crohn's fighter · Taken for 6 months to 1 year June 23, 2020

“I have been taking Zoloft for several months. I have IBS which flares up when I'm anxious, and Zoloft really helps with that. It has very few side effects and I feel more like myself when I'm taking Zoloft. I do have one small complaint: when I miss a few consecutive doses I tend to get dizzy. But that's it! Other than that, I have no issues with Zoloft. It's very subtle, and it certainly has improved my mood.”

9 / 10
Jay · Taken for 1 to 6 months June 8, 2020

“I started taking zoloft after 8 months of post concussion syndrome symptoms. My anxiety and very low mood were affecting every aspect of my life. I was suicidal. I started with 50mg for the first month. Only side effects for me was a bit of nausea the first week and a lack of appetite. By week 4 we went up to 100mg and everything has improved significantly! I can separate emotions from facts which I couldn't do before. The people I thought were "against me" don't seem to bother me whatsoever now. I've gotten my life back. I have energy and an optimistic attitude. My friends and family have noticed in big ways. It's been a life changed for me. The only thing I would say are side effects Low libido Shortened Sleep. I usually wake up in the middle of the night now.”

10 / 10
Stone · Taken for 1 to 6 months June 7, 2020

“I’m 50 and have struggled with anxiety because of my 26 year relationship with my wife. After 60 days I don’t have the breakdowns any more and can function. Zoloft helped me to close off to her and begin to feel safe emotionally. It really works.”

9 / 10
Anonymous · Taken for 1 to 6 months March 10, 2020

“I started taking sertraline around 5 weeks ago today (25mg). The first few days were fine, I only had a bad stomach for a day or so. However at around week 2 I felt awful, was having extreme suicidal thoughts. I carried on taking the medication as I know it gets a lot worse before it gets better. At 5 weeks now, I have increased my dose to 35.7mg and I feel pretty good. Haven’t had any side affects from increasing the dose slightly just yet. It’s worst sticking it out through the hard times, there is defiantly a light at the end of the tunnel!”

8 / 10
Hope4U March 1, 2020

“Teenage son was on Lexapro then Zoloft gradual transition of 10mg lexapro + 50 mg Zoloft for 2 weeks then 3rd 50mg of Zoloft. Next 3 weeks, was totally insane with side effects. Week 3, Zoloft increase to 100 mg with 50 mg of Seroquel for sleeping. We were wondered if Zoloft making everything worst, but we hung in there. So glad we did; by week 4 seem like everything reach an equilibrium point; it was like - my gosh what is happening...the depression, anxiety, compulsive behavior went from a 10 to a 3. He was able to control & process thoughts, listen to advice, paused more to think things through before his responses, in general very talkative about everything. Something totally wonderful happened the 4th week and continues to this day. He is now receptive to knowing the Zoloft medication has pulled him thru a very dark place and now voluntarily open to continue therapy. For us the Zoloft medication is working. Yes, it did take time & a lot of patience to see the results.”

10 / 10
Joanna · Taken for 6 months to 1 year February 29, 2020

“Been on this med for about a year. 100 mg is the best dosage for me. Really does help depression, but doesn't take away normal grief. When you're happy , but I find that on it, you're really happy and calm, when taking your pills daily and not skipping doses. I found that combining with high quality magnesium also really helps my mood. The combination is great. Magnesium alone did nothing.”

8 / 10
Mary · Taken for less than 1 month February 28, 2020

“Starting zoloft again at a dose of 25 MG today. I was on it a couple months ago at a starting dose of 50 MG. I didn't have many symptoms the first time around for two weeks. Week third, probably when it build up in my system, I experienced a continuous migraine along with high pitched ringing in my ears. I was also very constipated, bloated and had dry mouth and was very fatigued throughout that third week. I also lost my appetite and couldn't reach an orgasm. I was very uncomfortable and emotionally unstable during that whole third week. I stopped taking it and all symptoms ceased within 72 hrs. I saw my doctor who put me on wellbutrin. Wellbutrin was awesome, but unfortunately I can't continue taking it during the long term dental work I'm having done. I hope this time zoloft, with a lower dose, will not cause the same symptoms it did initially. Wish me luck.”

1 / 10
Ellie · Taken for 2 to 5 years February 23, 2020

“Hi everyone, I am glad to find a place that I can tell my story & maybe get some opinions. I started taking Zoloft when my husband of 53 years passed, that was 3 years ago. I had the doctor give me instructions on weaning from it in November. So now it has been 8 days off. I did not have any side effects until today. After I got home from church I just broke out in tears & I am not a crier. Is it normal to get this effect after 8 days off? I really would like to stay off the med. Thanks”

7 / 10
Chris · Taken for 1 to 6 months February 19, 2020

“Increased anxiety dramatically the first few days I took it - to the point I thought I would have a panic attack while I was driving. This levelled off but after every morning dose it would increase my anxiety a bit. Helped with depression I think but unfortunately after a month I started developing sexual side effects and had to cease.”

6 / 10
Anonymous · Taken for less than 1 month February 17, 2020

“Day 18 on Zoloft started with 50mg increased to 75mg after day 7. Day 11-15 were terrible days, I felt a lot of anxiety mixed with crying, lost of appetite and I experienced panic attacks in the early mornings three days in a row (I’ve never once had that issue before). My physician added 10mg of Buspirone twice a day to help fight those battles and it helped. Today was a beautiful day — I don’t remember a signal thought holding me back, I felt balanced. Hope this continues.”

8 / 10
Symone · Taken for less than 1 month February 16, 2020

“I was on the medicine Zoloft for 4 days I experienced hallucinations, heart racing, shaking, blurry vision, insomnia, dry mouth, shivers & I can’t remember if I ever went to sleep one night”

1 / 10
Mich · Taken for 1 to 6 months February 10, 2020

“This drug saved my life. I started having chronic anxiety and depression very suddenly, and insomnia. I am so thankful for the positive and encouraging reviews on websites like this, because they helped me push through this difficult time, and I hope to do the same for someone else. I agree with many other reviews that it does get worse before it gets better. My anxiety increased at first, I think out of desperation for each day to finally be the day I would feel normal again. But it takes time and patience, and there will be ups and downs. I started seeing improvement around 4 weeks, but took a dive again around week 5 before increasing my dosage. Now I am at about week 7-8 and I would say 90% myself again. I highly recommend doing therapy too, and Xanax has helped curb the increased anxiety while my body adapts. Side effects are minimal, just nausea if I don’t take it with food. Zoloft helped me get my mind back under control and enjoy life again!”

10 / 10
JMM February 7, 2020

“2 mths ago I was desperately going through these pages to find something positive about sertraline My had mother died and my daughter, 3 weeks after, went into treatment for 6 weeks for anorexia. Long story short, I had an acute panic/anxiety/depression event in early December. I started on Zoloft 25mg on Dec 11. I had most hours of feeling 'ok' but I was frustrated that I was still feeling that adrenalin and anxiety. By week 5 I was still frustrated by feelings of anxiety. Then everything lifted. I promise you will feel better. I absolutely promise. Stick with it. But do the work too! Go out! Exercise! Eat well! (I had no appetite!) Don't watch the news. Look for the small things. And read or listen to Claire Weekes on you tube (it's like your grandma giving you a talking to) xxx You will be better x”

9 / 10
Dantheman18 · Taken for 1 to 6 months February 6, 2020

“Zoloft really didn't do anything for me and my depression. I've been on it from August to December increasing up to a dose of 75 mg. I felt no different. I was still able to ejaculate so that was a little suspect too. This is just my experience. Ever since I just quit on the spot with no adjustment I've been feeling worse though.”

4 / 10
Bad mood February 3, 2020

“Thank you all for sharing your experiences. I was on Zoloft 10 years ago ( back in 2009), for 6-7 months only, took only a dose 50mg (started with 25mg) per day for mild depression ( or rather bad moods). It worked well for me and had no side effects, maybe I was drinking more water only (dry mouth feeling). I felt very happy - my mood was up , even maybe a little too high ( my friends noticed that as well), but I felt happier, also I became very brave :-) started to tell people things i would usually be afraid to do before. So my doctor smiled at me and said - congratulations , you are healthy now! So after 6 months I discontinued ( slowly dosage down), as I felt totally fine. I would love to take again this medicine, but I am very sad to read the reviews and wonder that they have changed the formula of Zoloft and side effects have gone worst :-( this is true? Why would they do that? Anyone could share their experience old zoloft and recent formula zoloft effects? Thanks”

8 / 10
Francis January 28, 2020

“Was issued a prescription of Zoloft 6 months ago, the worst time of my life, everything declined. My physical and mental health, shaking, no follow up in what I start, neurotic, depressed, anxiety attack, eyes problems, ears ringing.....I decided this week end that I will go back to what I was under before. NOT FOR ME!”

2 / 10
D · Taken for 6 months to 1 year January 23, 2020

“I was on Zoloft for depression and I felt like the greatest thing since sliced bread. I thought I perfect. However, the people around me saw someone different. I became crazy and I completely changed for the worst. I was very violent and at one point I woke up in the morning, walked in the kitchen where my family was eating breakfast and slammed my head against the wall and just walked back upstairs.. I was loud and obnoxious. My parents actually begged my psychiatrist to take me off of it. Flash foward to today- Depression free and happy. The best thing I've ever done was stop taking anti depressants and reduced my marijuana smoking. Look up the correlation between depression and marijuana...”

1 / 10
kitty January 18, 2020

“I was experiencing depression and sleep issues. 1st tried Effexor 37.5. From 1 pill, I was throwing up all night with a pounding headache. Felt shaky+defeated rest of the week. Doc prescribed Zoloft 25mg. Took 12.5mg for first 4 nights with TylenolPMs. Felt no side effects from Zoloft +was finally sleeping again. Got a new job; relief. 25mg for a few weeks felt a bit better, but couldn't tell if it was from Zoloft or from life changes and was still feeling a bit empty. Upped to 50mg. It's only been 3 weeks but I feel better+better. It's kinda subtle so far but I feel myself smiling more. Nearly no side effects except major CONSTIPATION. Pharmacist told me meds can cause this. Laxatives are barely working, will try daily Metamucil. Assuming I can get my system back to normal, I think it's worth it. I'm not shaky, drowsy, etc. And I feel better.”

9 / 10
Val · Taken for 1 to 2 years January 14, 2020

“Horrible, I was constantly sad on Zoloft, never wanted to leave my house or do anything. I never really felt happy, I was always just kinda mellow and sad. When I finally got off of it was was actually happy and chose not to go on any medication at all and I’ve been doing great ever since”

1 / 10
2020 · Taken for 1 to 6 months January 14, 2020

“Hello, I have been taking Sertraline for almost two months and I give it 10 out of 10, I feel amazing! In addition to taking the medication, I created my own healing plan: drink water, 8 hour sleep, cognitive behaviour therapy, cut off alcohol, caffeine and sugar, eat vegetables, fish, fruits and nuts, exercise 3 times a week, take vitamin D, B12, magnesium, spend time with friends and family, enjoy the sun, do something fun, meditate and do yoga (try these apps: Calm and Headspace). There is also a free app called Flow which help you to treat depression, have a reiki session and let go what is not making you happy (job, relationships, addiction), etc. Medication is great but you need to look at other aspects of your life as well to heal :-)”

10 / 10
Nicolefreel · Taken for less than 1 month January 9, 2020

“I went on Zoloft for 4 days. I had been on it before and did not experience any side effects. However this time I experienced every side effect in the book, dizziness, drowsiness, hot flashes, nervousness, shaking, nausea and vomiting, diarrhea. Most importantly, my mental state declined immensely. I felt 100x worse on the pill than before taking it. I had uncontrollable crying, anxiety attacks and feelings of hopelessness. I really scared myself and I felt that I was never going to get better. And this was only after 4 days of being on the medication and I was at my lowest point I ever have been. This was not the right medication for me.”

3 / 10
Marie · Taken for less than 1 month January 8, 2020

“I've only been taking Zoloft for about a week, so I haven't gotten to feel the full effects... but I will say when I introduced Zoloft to my body the first day, I had serious side effects. Insomnia, anxiety when I closed my eyes, strange thoughts (non dangerous), dizzy. I felt super exhausted and tired but energetic at the same time. Didn't sleep entire night. The next few days I wake up periodically to my limbs twitching like crazy, I have bruxism (grinding of teeth) and sometimes I wake up by jumping upright or throwing myself around in bed. My left pupil is more dilated than my right. I will say, aside from side effects - everyone around me has noticed I am much more calm lately. I am taking it for OCD, depression, anxiety, and panic attacks. I do get random anxiety at night due to side effects, haven't felt depressed at all in a week. I hope the side effects subside because my sleep is atrocious, and bruxism causes migraines.”

8 / 10
Vicki · Taken for 1 to 6 months December 22, 2019

“This is a very irresponsible website in that you do not instruct the reviewers to state the AMOUNT of Zoloft they take. Without knowing the amount the reviewers are taking, it just amounts to a bunch of worthless babble. It is of no use to anyone.”

7 / 10
KS December 20, 2019

“I was put on Zoloft a month ago. I'd gone to my doctor after a recent breakup and mentioned I had really bad anxiety attacks throughout my last relationship as he'd cheated on me and it was an emotional traumatising. My doctor prescribed me with Zoloft. Within a week I was having active suicidal thoughts, I went back to the doctors and said something felt wrong. They said I should let the antidepressants settle in over a six week period and it would be all fine. Taking this advice I stayed on it - then a few days later I tried to overdose and was hospitalised. The psychiatrists were so shocked I'd been prescribed Zoloft and said doctors are often too quick to medicate. It was the scariest experience of my life, and I'd warn anyone else who is prescribed this to really think about it. Now instead of working through the emotions of a break up I was working through the pain of a mental illness bought on by antidepressants.”

2 / 10
Jamie · Taken for 1 to 6 months December 18, 2019

“It made me feel a little better- it lifted the sadness that I feel all the time but only slightly. I still feel the depression, and it has made my positive emotions feel weaker, almost like the things that made me happy aren’t as powerful anymore. My OCD has worsened and the (very) slight improvement in mood is outweighed by the negatives I’ve experienced. Overall, my anxiety is less and I feel less fragile. As time goes on this effect is becoming less strong, but the side effects remain. I am going to talk to my doctor about switching, it’s been 6 weeks with little improvement.”

4 / 10