Trintellix Dosage
Generic name: VORTIOXETINE HYDROBROMIDE 5mg
Dosage form: tablet, film coated
Drug class: Miscellaneous antidepressants
Medically reviewed by Drugs.com. Last updated on Mar 5, 2025.
Recommended Dosage
The recommended starting dose is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated. The efficacy and safety of doses above 20 mg/day have not been evaluated in controlled clinical trials. A dose decrease down to 5 mg/day may be considered for patients who do not tolerate higher doses.
Screen for Bipolar Disorder Prior to Starting TRINTELLIX
Prior to initiating treatment with TRINTELLIX or another antidepressant, screen patients for personal or family history of bipolar disorder, mania, or hypomania.
Discontinuing Treatment
Although TRINTELLIX can be abruptly discontinued, in placebo-controlled trials patients experienced transient adverse reactions such as headache and muscle tension following abrupt discontinuation of TRINTELLIX 15 mg/day or 20 mg/day. It is recommended that the dose be decreased to 10 mg/day for one week before full discontinuation of TRINTELLIX 15 mg/day or 20 mg/day.
Switching a Patient to or From a Monoamine Oxidase Inhibitor (MAOI) Intended to Treat Psychiatric Disorders
At least 14 days must elapse between discontinuation of a MAOI intended to treat psychiatric disorders and initiation of therapy with TRINTELLIX to avoid the risk of Serotonin Syndrome. Conversely, at least 21 days must elapse after stopping TRINTELLIX before starting an MAOI intended to treat psychiatric disorders.
Use of TRINTELLIX in Known CYP2D6 Poor Metabolizers or in Patients Taking Strong CYP2D6 Inhibitors
The maximum recommended dose of TRINTELLIX is 10 mg/day in known CYP2D6 poor metabolizers. Reduce the dose of TRINTELLIX by one-half when patients are receiving a CYP2D6 strong inhibitor (e.g., bupropion, fluoxetine, paroxetine, or quinidine) concomitantly. The dose should be increased to the original level when the CYP2D6 inhibitor is discontinued.
Use of TRINTELLIX in Patients Taking Strong CYP Inducers
Consider increasing the dose of TRINTELLIX when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for greater than 14 days. The maximum recommended dose should not exceed three times the original dose. The dose of TRINTELLIX should be reduced to the original level within 14 days, when the inducer is discontinued.
Frequently asked questions
- How long does Trintellix withdrawal last?
- Does Trintellix cause sexual side effects?
- How effective is Trintellix for depression?
- Is Trintellix the same as Brintellix?
- Does Trintellix (vortioxetine) cause weight gain or loss?
- How long does it take for Trintellix (vortioxetine) to start working?
- Is Trintellix (vortioxetine) good for anxiety?
- Shall I take Trintellix (vortioxetine) in the night or morning?
- Can I take Cymbalta (duloxetine) and Trintellix (vortioxetine) together?
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