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User Reviews for Bupropion to treat Depression

Also known as: Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion SR Forfivo XL Budeprion

Bupropion has an average rating of 7.0 out of 10 from a total of 1218 ratings for the treatment of Depression. 60% of reviewers reported a positive experience, while 19% reported a negative experience.

Bupropion rating summary

7.0/10 average rating

1218 ratings from 1303 user reviews.

Compare all 188 medications used in the treatment of Depression.

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14%
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Reviews for Bupropion

Max · Taken for 6 months to 1 year · October 19, 2020

Wellbutrin XL (bupropion): “Real and honest review. I’m a 52 yo male living in Canada. I’ve been suffering from Anxiety/ADD/Depression forever. I resisted and procrastinated to take meds again for “years” because of not so great experiences with SSRI’s but also because I read way too much online which scared me off. So I suffered for years until one really bad episode that forced me to take action. I asked my doc to give me Wellbutrin (Bupropion) since it had the least negative reviews (from my years of online self-help nonsense). Started 150mg of Wellbutrin XL for 3 weeks then 300 mg plus 10mg of Citalopram ever since . It’s been LIFE CHANGING really! It’s crazy how I can finally function like a normal human being. I swore to myself that I would write a review here if I found the remedy to my suffering, so here it is. Wellbutrin XL 300mg+10mg of Citalopram has worked “wonders” for me. No more Anxiety, very low ADD and NO MORE depression I really hope this helps a few of you out there.”

10 / 10
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Courtney R · Taken for 1 to 6 months · April 23, 2021

Wellbutrin (bupropion): “Background: depression, anxiety, intrusive thoughts, seasonal depression I went with Wellbutrin because it had the least side effects compared to most depression medications and it was recommended by many people. I must say it really has been life changing. When I started Wellbutrin it made me think much clearer. While I still do get thoughts, they are not intrusive. My mood is stable and I feel generally happy! Week 1- sensitivity to caffeine, racing heart for one day, increased energy, appetite decreased Week 2- energy balanced out, appetite low Week 3- appetite back, energy consistent, mood improving, felt happy and no intrusive thoughts Week 4- I feel great! I do sometimes experience ringing in my ear, but nothing that is bothersome. Overall, this medication has saved me. I recommend taking this medication while seeing your therapist. Both of them together have really pushed me in the right direction.”

10 / 10
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Browntrout · Taken for 2 to 5 years · February 27, 2020

Wellbutrin XL (bupropion): “I always had a funk before I started taking Wellbuitrin. It was an underlining stress that I couldn't kick. It was hard to manage my stressful job and family. Wellbutrin has literally changed my life in so many positive ways. I manage stresses better, the feeling of a looming funk is gone and I've gotten really into running and lost a lot of weight. After about 2 years of being on Wellbutrin I slowly stopped taking it. After a few months of not being off of it I could feel familiar old feelings coming back. I've decided I like who I am better on Wellbutrin and started taking it again. Long story short I've very happy with this medication.”

10 / 10
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Kai2277 · October 10, 2018

Wellbutrin (bupropion): “I had an odd situation where I was not really depressed with sadness but I just felt nothing. I never got angry, never got happy- never wanted to do anything besides lay in bed. I tried to fake it as much as possible but I couldn’t anymore. I stopped answering my phone, lost all interest and motivation. I had taken all the antidepressants on the market but they made me feel crazy. My hands shook and I felt out of my body. I started researching the symptoms of low dopamine and I had almost all of the symptoms- poor memory, poor concentration, excessive worrying, lack of motivation- and overall just not giving a $#|+ about anything. I asked my doctor for Wellbutrin. In a couple of days I was calling old friends, kicking butt at work, and motivated for life again. My problem all along was dopamine not serotonin. I am thankful I figured it out. DON'T GIVE UP. Read about brain chemicals- dopamine, serotonin, and, norephenephrine- and make the choice based on research.”

10 / 10
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Michigan Girl · November 20, 2019

Wellbutrin XL (bupropion): “I have been clinically depressed at various times in my life (postpartum and SAD) but have avoided medication for it. Recently I’ve been weepy, couldn’t get moving, and chores/phone calls/bills began piling up - No energy to deal with life. I talked to my GP who suggested Wellbutrin. I was hesitant but desperate to function again. It worked within a week. I am on 150 mg, XR. I was diagnosed with ADD as a young adult, and Wellbutrin is like the gentler, kinder version of Adderall. I have focus, can complete tasks, am happier. I have energy and willpower to exercise (instead of thinking about it all day and then feeling guilty for not doing it). I have less of an appetite, but not because I feel manically energetic/hyped up/shaky...Binging (which I did before) is not even a thought in my head. I’ve been on Wellbutrin for two and a half months, lost about 12 lbs. I would like to take Wellbutrin for the rest of my life - never felt this calm, even and steady, and capable.”

10 / 10
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Cancer2Depression · September 5, 2020

Wellbutrin (bupropion): “I was a 250 pound fat and happy married man until I was diagnosed with stage 3B cancer. My wife and kids convinced me to see a Psych and get treated. Anyway, he started my on Wellbutrin (BUPROPION generic) at 200mg per day. He said this med has been around a long time and it's very safe and effective. Note that I don't have Anxiety. After a week on BUPROPION, I would sing on the way to work and was unable to take the smile off my face. After about 6 months these feelings wore off, but I was still better than before. My Psych upped the dosage to 300mg per day. I take two 100mg pills at 9am and then one 100mg pill at 230pm. Overall, I'm happy. It worked for me. Only side effects are a little insomnia twice per month and ringing in my ears 4 times per month, which lasts for hours each time. The ringing is very low. I get my meds Generic for a 90 day supply each time and my insurance charges me $24 for that 90 day supply (300mg/day).”

9 / 10
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AJ · Taken for 1 to 6 months · August 6, 2020

Wellbutrin XL (bupropion): “I took Wellbutrin XL for 6 months, the first 3 months my dose was 150mg, the last 3 months dose was 300mg. I was taking it for anxiety and depression. Took a little getting used to, but nothing terrible. In the 6 months I went from 150 lbs to 128 lbs (part of it was appetite-suppressant, part was that I had the energy to go out and do things/exercise). When I was at 150mg I had more anxiety attacks, but when I went to 300mg I felt like a normal human being (still having panic attacks, but they were due to being in a bad relationship). I loved this medication, only got off because I am now pregnant and didn’t want to worry about whether it was safe for the baby or not. Will be going back on once my baby is born.”

10 / 10
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Frequently asked questions

TheTwizler · Taken for less than 1 month · June 1, 2020

Wellbutrin (bupropion): “I'm on day 3 of wellbutrin. So far it's been miserable. I'm on the lowest dose and still having horrible stomach side effects. I can't eat, I have no appetite, severe diarrhea with intense stomach pain. I'm also exhausted but can't seem to sleep more than a few hours at a time. My mouth is dry and my eyeballs feel like sandpaper. And to top it all off, just looking at my husband arouses me. I'd actually enjoy that side effect if I could stay off the toilet. I'm gonna try to stick it out in hopes that this will pass. I know I need to give it some time.”

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Grateful_Bread · Taken for 1 to 6 months · November 9, 2019

Wellbutrin XL (bupropion): “I am prescribed 150 mg of XL and it has been a God-send. I could not get out of bed, no sex drive, thoughts about suicide and I burned some work bridges with adjusting firms that I was working for bc I was suffering silently. I was also living in filth (by myself which didn't help matters) I was diagnosed with depression and began this med immediately. Now as soon as I wake up (fully erect again mind you) I am ready to tackle the day. I am in a great mood and am very hopeful for the future. I have a 1973 VW bus that I bought as a project and it sat the last 6 months. In the last few weeks I have done more to it than I have since I bought it. The magic bus is running again. Sort of a metaphor for my life. I moved out of the apartment as I had some dark memories there. I feel like my old self again and have my life back! I hope the same happens for any of you suffering with this affliction. Keep on truckin!!!”

8 / 10
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Anonymous · March 30, 2021

Wellbutrin (bupropion): “Saved my life and marriage after I had severe PPD and PPA. I would still have some bad anxiety every once in a while but overall totally worth it. I also found that Benadryl really helps if you have anxiety with this at night. I was able to gain the confidence to start my own business and actually believe for the first time in my life I could truly accomplish something. I pray this med helps others like it’s helped me.”

10 / 10
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Boog · Taken for 6 months to 1 year · January 6, 2020

Wellbutrin XL (bupropion): “I've been on Wellbutrin XL 150mgs for about a year now and I've gotta say it's worked wonders for me. I was on Lexapro a few years ago and stopped taking it because the weight gain and zero sex drive was bringing me down. I wasn't taking any antidepressants for a year and a half and still couldn't lose the weight. My doctor put me on Wellbutrin, which I was nervous about at first because I also have generalized anxiety disorder and I read that it could exaggerate it. The first month I had splitting headaches and was only sleeping maybe 4-5 hours a night. Since then, things have obviously evened out, but it did take a few weeks. I feel great now, I'm energetic and passionate about things I haven't been in years. I started at 168lbs and have lost 30 pounds; I'm officially down to my pre-lexapro weight. I'm so glad that this medicine works for me, it's made such a huge difference in my day to day!”

10 / 10
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rasinsomniac · Taken for less than 1 month · May 27, 2020

Wellbutrin (bupropion): “After a break up with my girlfriend and one true love of my life I went to a really dark place and had serious suicidal thoughts. I was first put on Brintellix, then Valdoxan and three weeks ago to Wellbutrin. It's been six months since the break up and after using this med for 3 weeks I'm finally able to enjoy life again and have energy to get through the days with pleasure. This med has so far been a life safer for me. First two weeks were hard and I had serious insomnia but now for the first time in 6 months I don't need Ambien to sleep anymore. I seriously recommend this med, at least for me its working perfectly so far. Just give it time to start working and you will feel better.”

10 / 10
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Nathalie21 · June 6, 2021

Wellbutrin (bupropion): “Just starting this med. The first couple days, I didn’t think it was doing much, but I noticed I couldn’t sleep for very long. I wasn’t as hopelessly sad as I had been the week prior, but I was experiencing an array of stomach-related side effects (constipated until I was very much no longer constipated, bloating, stomach aches, & VERY nauseous the first night). Fast forward a few days, I still can’t sleep very much. I’m artificially active is the best way to describe it. I’ve been pretty inactive throughout the pandemic, but I walked to get iced coffee in 90 degree heat, cleaned my apartment, had people over, then went to the gym later because I was so jittery and couldn’t sit still. It also has given me quite a bit of anxiety and some irritability alongside the constant need to be active. I hope that over the next few days, the anxious thoughts, stomach issues, & insomnia calm down.”

8 / 10
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struggler79 · January 17, 2015

Wellbutrin (bupropion): “I am a 35 year old woman, who has taken meds for 1/2 her life. I struggle with obsessive compulsive disorder, intrusive thoughts and overall depression. Wellbutrin.. I take 150mg a day. It has changed my life.. I have less obsessive thinking, more motivation and for some reason care way less about what people think.”

9 / 10
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slh182 · Taken for 1 to 2 years · November 4, 2019

Wellbutrin XL (bupropion): “I have been on hundreds of anti depressants since I was 14 (I am 37 now), and Wellbutrin is by far the best one I have taken. It helps motivate me and gets me out of bed in the morning. Before Wellbutrin I always felt sluggish when I first woke up but now I am up bright and early in the morning with tons of energy thanks to Wellbutrin. Before starting it I had spent days in bed with absolutely no energy and feeling hopeless about life but Wellbutrin put an end to that. I’m hardly ever depressed now, I have loads of energy and motivation and suicidal thoughts have disappeared. In the past the antidepressants that did work took months to feel the effects but Wellbutrin started working within 4 days! I am so happy that after struggling with depression for 23 years I have finally found my miracle anti depressant.”

10 / 10
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ZT · March 12, 2014

Wellbutrin (bupropion): “Five months after my Daughters fatal car accident, my Dr. suggested Celexa for my depression. I took it for 6 months. It made me worse, my Dr. thought that Wellbutrin might be better. It has really helped, just after 3 weeks I've noticed a big difference in my life. I take 200mg per day and now I can finally get on with my life knowing that some day we will be together.”

9 / 10
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Woody · October 2, 2020

Wellbutrin (bupropion): “I began Bupropion about a year ago. Took a while to kick in, Waiting eight weeks for the hoped-for effect was like waiting eight months. I had tried another med and it left me with negative sexual side effects which is why the doctor suggested Bupropion. I've been taking low dose Viagra, honestly don't know if I need it . . . but Viagra works. I told my doctor that I'm okay, but don't seem to feel any drastic change from when I first began the med. She suggested upping to 300 mg extended release. After a week I began to feel better but, don't know if it is from the med or the high of knowing I made the attempt at trying to feel better. Wishful thinking is a good way to put it. So here's my question: Since I was already taking Bupropion at 150 mg/day extended release should I expect the new dosage of 300 mg to take eight weeks to fully kick in? Has anyone had this experience?”

9 / 10
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Leigh · Taken for 1 to 6 months · January 2, 2021

Wellbutrin (bupropion): “When I tried an SSRI I ended up lying on the floor almost unresponsive. I won't take one again. In the last year my depression and anxiety got really bad. Horrible panic attacks, slamming doors, screaming, irritability... then came the suicidal thoughts. My doctor suggested Wellbutrin. I have a very sensitive body so I started on 75 mg once a day. Man. I noticed a difference within the first day or two. The third day I woke up with tons of energy and unpacked my suitcase that had been sitting in my closet for a week, before I even started working! Unheard of for me. My outlook on life has improved, I don't snap at my husband, I don't get annoyed. Plus I've lost 4 lbs and my sex drive has increased slightly. The only side effects I've had were the brain "zingers" people talk about (they have subsided) and pretty bad insomnia. I'm hoping the insomnia goes away, but right now the positives definitely outweigh the negatives! A world of difference!”

9 / 10
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Pr23 · December 23, 2019

Wellbutrin (bupropion): “Okay, I came back to rate again. It has now been about a little over a month on Wellbutrin and wow it has saved my life. It was like a total switch in the way I think and feel everyday! For years and years I’ve been depressed but this year was so bad,I didn’t care about myself. I was also so unmotivated.. crying multiple times a day even while at work.. I’d be triggered by anything and start having anxiety attacks. Now, I can finally say I am happy with my life! It’s like I can see my life clearly now, it’s no longer a fog, I don’t obsess over all the negative things... I have energy to go to the gym often and eat right and I’ve lost over ten pounds. I have goals again and I have my self confidence back.I t feels unreal I did miss a few pills every other day for about a week and a half and I felt a difference, I cried once and I was also binge eating. But I went back to normal once I went back to taking all my pills on time.”

10 / 10
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jkn1416 · January 1, 2015

Wellbutrin (bupropion): “Before starting Wellbutrin I was so depressed, crying all the time, no motivation, no energy, no ability to make decisions or follow through with them, no desire to go anywhere. I've been taking Wellbutrin for about 3 weeks and within a 5 days I was noticing a difference. The crying has stopped, I'm more motivated, I have more energy and I'm making decisions I couldn't before. I have been active, forcing myself to go to the gym but now I'm more eager to go. Wellbutrin has made a huge difference for me.”

9 / 10
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KB80 · October 6, 2014

Wellbutrin (bupropion): “Well I am very pleased to tell you that I started Wellbutrin XL 150mg for depression and anxiety and I can honestly say that it is a miracle drug! I started feeling much better after just one day, I could not believe it. It has been 30 days now and I have not had even one side effect. My depression went away almost right away and the anxiety took a couple weeks. But 30 days later I feel completely myself again. This medication is definitely doing its job 100%.”

10 / 10
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Hannah · Taken for less than 1 month · December 8, 2019

Wellbutrin (bupropion): “Best medication I’ve ever taken. I didn’t realize how depressed I was before taking it. Now I have energy to get through the day. It also helped with my obsessive thoughts. I’ve never felt so much relief in my life. The only side effect is a slightly dry mouth but I’d take that any day over the hell I was living in.”

10 / 10
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Anonymous · October 25, 2014

Wellbutrin (bupropion): “I am not a proponent of Big Pharma, and have always had to try to "deal" with my problems on my own. I have a really excellent diet, exercise, don't smoke, eat an organic diet - I'm just saying I really take care of myself. I have had anxiety (with a little bit of depression) all of my life. I was diagnosed with PTSD a few years ago, as I was having severe anxiety about being accepted into nursing school, and if I would be able to handle to stress and constant pressure, and I also have concentration problems. I have been off and on SSRIs, which have been nothing but terrible for me...Paxil, Zoloft, & Prozac, of which made me feel like a zombie. Wellbutrin is GOLD. Not tired, less irritable, not panicky. It has changed my life.”

10 / 10
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MJ · February 6, 2021

Wellbutrin XL (bupropion): “I was diagnosed with Bipolar II and C-PTSD in 2015. I tried a handful of different medications, but I was also dependent on alcohol. I stopped drinking August 2020 and soon after went med-free (supervised) to see where I was at. What appeared to come about was depression mostly. When I started 150mg buproprion HCL XL, within 48 hrs I felt more energy, more activated emotions, less fog. It caused me to be more agitated and angry at first, but I knew it was because I was coming from complete numbness to actually having some feelings. I am now a month in and I feel happy about where I am with my mood. I say definitely give it a chance, especially if you are not a fan of SSRIs. Give it a few weeks and log your feelings. Being on this is far better than where I was in my depression. I wanted to share my experience and feelings because it has given me some hope and I want to share that with others.”

8 / 10
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Crissy123 · May 12, 2014

Wellbutrin SR (bupropion): “I am a mother of 2 small children and I began this medication about 2 months ago after being on Celexa (which made me feel tired a lot and hungry all the time - I gained like 20 lbs on it). The first thing I noticed with Wellbutrin was a decreased appetite. Then I started to feel more alert - the same kind of alertness you would feel when taking Adderall. A few weeks into it, my mood was totally different. I was happy, calm, energetic - all the things that I wanted for so long, but never thought I could achieve, as I was very depressed. I was walking in a parking lot the other day and I thought to myself "wow. isn't life great?" - Wellbutrin is an AMAZING medication.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.