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User Reviews for Bupropion to treat Bipolar Disorder

Also known as: Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion Forfivo XL Budeprion SR

Bupropion has an average rating of 6.9 out of 10 from a total of 75 ratings for the treatment of Bipolar Disorder. 63% of reviewers reported a positive effect, while 23% reported a negative effect.

Bupropion Rating Summary

6.9/10 average rating

75 ratings from 79 user reviews.

Compare all 80 medications used in the treatment of Bipolar Disorder.

10
24%
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28%
8
11%
7
3%
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1%
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7%
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4%
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3%
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7%
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13%

Reviews for Bupropion

Mahyar · Taken for 1 to 2 years June 30, 2020

“I give this a 10 to this miracle drug. About 10 years I was under treatment for Bipolar Depression, Seasonal Affective Disorder and General & Social Anxiety. I try different drugs (SSRI drugs has made me hypo-manic) until one day my doctor add 150mg of Bupropion to Depakene and quetiapine and suddenly everything has changed. At first I had body dehydration, restless sleep and bad headache for about one month but Day by day the side effects has gone and my energy has boosted, my anxiety has gone. I enjoy being socially active. My winter blue has gone. Depakene's numbness has gone. I try 300mg after 6 month but it gave me Heart palpitations. Now after one year I'm stable and happy at 150 mg and really really really suggest this drug to give it a try. Finally I want to thank the inventor of this medicine. <<Sorry For My Bad English>>”

10 / 10
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Bob October 4, 2018

“You know, it's interesting to get on a medication like Bupropion and suddenly (literally within two days) start to notice an internal change in the way you think, feel, and behave which in turn makes you realize how seriously sick you were for most of your life.”

10 / 10
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A-nonny-mouse · Taken for 2 to 5 years October 13, 2019

“If you have Bipolar Disorder type II, please learn as much as you can about this condition from professional, reputable sources so you can make informed decisions about treatment and management options. This is a treatable, manageable illness, take hope in that. After 20+ years struggling to "cure" myself "naturally" & being miserable, dangerously depressed & dysfunctional, I finally decided to try psych medication. I found a doctor who SPECIALISES in this disorder and is up to date with the latest research findings in this specific condition. If you don't like your current GP or Psych's attitude, find someone else! I started a combo of Lamictal (AM & PM) & Seroquel (Only PM - makes you drowsy). I kept a daily mood diary & it took 3 months for my mood to fully stabilise. To help the bipolar depression, we added bupropion & N-Acetyl Cysteine, a supplement (all based on clinical research!). For 5 years now, I’ve had my life back. Deciding to take this medication saved my life.”

10 / 10
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Whaddup · Taken for 6 months to 1 year November 23, 2019

“I LOVE THIS MEDICATION!! After trying Lexapro which ended up not working at all, (I found out I genetically don’t respond to SSRI’s), my psychiatrist prescribed 150mg of Wellbutrin XL(Bupropion HCL). This is the only thing that was able to pull me out of a deep depression! Before this medication I had constant suicidal ideation, and would always be upset/having crying episodes. I would hate everyone and everything. Even though I still experience a little irritability from time to time, I’ll take it over the symptoms I was experiencing before. I did have to bump up my dose to 300mg though eventually because I was still experiencing breakthrough symptoms on 150mg. This medication combined with Lamictal changed my life!!! Currently, this is the best I’ve ever felt.”

10 / 10
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harley · Taken for 2 to 5 years November 24, 2020

“I have been on lithium carbonate for bipolar disorder for 30 years. I always had incredible anxiety and debilitating panic attacks. I added wellbutrin to my regimen which I did not want to do initially, however it has worked so well for me I haven't had an anxiety or panic attack since starting. In the beginning it wasn't easy, I was losing hair and all kinds of crazy stuff for 3 weeks. Once I got through that it's been fantastic. I would highly recommend this to anyone! Major change in my life.”

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male, 29 · Taken for less than 1 month January 31, 2013

“I've been taking bupropion 200mg for roughly three weeks to treat Bipolar depression. I have not had success with any other antidepressants. For me, Wellbutrin has been great. It has increased my energy level dramatically, as well as improved my mood. It's not a cure all, but it's certainly helping. The side effects - I take it in the morning to avoid trouble sleeping. Increased my anxiety somewhat the first week. Higher libido. Markedly reduced appetite. I need to remind myself to eat, and I've lost 5 lbs. Others have mentioned a bad interaction with alcohol which I have not experienced. I've had up to three drinks with no problems. My overall experience has been good, this is a great medicine if it agrees with you.”

9 / 10
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Oussama · Taken for 1 to 2 years June 23, 2020

“I have bipolar disorder 2. SSRI did not work for me for 10 years. I stay in the hypomania stage for most of the time. Laziness no productivity. Lack of realism. After I started taking Wellbutrin XR 300 mg. I started to be active but then I started phase shifting to hypomanic stage. After lowering dose to 150 mg it took 2 months now I can feel pressure and have a sense of focus and urgency and I am for the first time productive but with no depression after like 13 years. I cope with depressive episodes with only 100 mg of etifoxine (non addictive) . low dosage is important for bipolar disorder. Wellbutrin saved my life.”

9 / 10
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Frequently asked questions

Anonymous August 15, 2020

“I was in a major depression episode for a year. Negative thinking and self image, hopelessness, suicidal thoughts, numbness, staying in bed for days, not showering, tired but sleeping excessively. I have tried: prozac, zoloft and lexapro. These medications made my depression worse and my suicidal thoughts increased. Wellbutrin regulates norepinephrine and dopamine neurotransmitters (NDRI), while Lexapro, Prozac, and Zoloft works with selective serotonin reuptake inhibitors (SSRIs). Started on bupropion 150mg and I was got hypomanic. After 2 months increased it to 300mg. My anxiety was increased but as my doctor explained I have always been anxious it is just more recognizable. Many say that it has made them hypomanic and more anxious. Bipolar II is more than just depression and hypomania. It also involves anxiety, mood irritability, compulsions, obsessive thoughts, and worries. This is when you start working on a mood stabilizer.”

9 / 10
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Anonymous February 16, 2009

Wellbutrin (bupropion): “I was prescribed this medicine for my bipolar disorder. It helped me a lot. I felt great and my relationship with my family improved. After 3 weeks though, I had a severe allergic reation to the Wellbutrin (bupropion) and had to go to the ER twice in a week. I had hives, swollen eyes and lips, trouble breathing, sore joints. As soon as I was taken off of it, my symptoms went away. It is not common for this to happen and I do recommend it.”

9 / 10
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Male, 57 · Taken for 5 to 10 years September 1, 2013

“I've been taking bupropion 450 mg/day, for at least five straight years. On two previous occasions, I would take it for a year or so and then refrain when things stayed sunny. Obviously they didn't remain that way, so this time around I'm firmly committed to it. I have had a tendency to rapid cycle. When I returned to bupropion the last time, the doctor also put me on Lamictal and Abilify. Last year, under her guidance, I weaned myself off of those. After all these years of dealing with BiPolar Disorder II, I am fairly well attuned to know when I might need to return to one or the other. I take bupropion, with food, soon after waking as it does interfere with sleep. I've had no other bothersome side-effects and no alcohol issues.”

10 / 10
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Killer Whales September 29, 2011

Wellbutrin (bupropion): “I am going to be as fair as I can be. As we can carefully repeat that not every medicine will work for everyone. But what I can tell you is that this medicine did nothing for me. Instead, it made my anxiety shoot through the roof, to the point where I thought I was being watched and stalked by law enforcements. I was deathly afraid of them taking me away, for what reason, I have no clue. It made me land in the psych ward. I would perspire in generous amounts! I would feel extremely guilty of past wrong doings (even the most minor thing I've done wrong in my life would be the topic of debate in my head). I wish you all a happy healing and good luck on your search. ”

1 / 10
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Bipolar2happy August 14, 2016

“I have taken this medication on two separate occasions: first in conjunction with Seroquel (quetiapine) and Neurontin (gabapentin) and second by itself without other psychiatric medications. Both times I took the 150 mg extended release form. When I took it the first time I didn't experience any mood-altering effects, but I did lose a significant amount of weight. In fact, my psychiatrist had to take me off the medication when I dropped below 90 lbs. The second time I took bupropion was when I had to come off lithium due to thyroid damage. This time it was life changing. All of my depressive symptoms melted away without inducing any hypomania. I still lost weight, but not as much this time around. This medicine makes me feel normal again.”

10 / 10
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Not meme karen September 4, 2020

“Been on Wellbutrin SR for almost a year for bipolar 2 with severe depression. Suicidal and crying constantly. I've taken all bipolar drugs to no avail. Decided to try Wellbutrin and norepinephrine/ dopamine reuptake mechanism is one I require to come out of depression. It's been a miracle drug. I virtually have no side effects other than ringing in the ears but that's fading. Definitely does not take away my anxiety and I will sometimes still have situational depression but no Suicidal Thoughts and no severe depression. There's no way I will take myself off this. This is the only drug I am taking. Poops were amazing initially, now more constipated. Also I drink alcohol regularly. Was scared initially because I didn't want to have seizures but guess since I don't have a propensity towards seizures the alcohol isn't causing any. Caffeine is no-go. Even decaf CBTL leaves me feeling super ill so I'm basically cutting out store-bought coffee but I can drink decaf at home no problem.”

10 / 10
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Bipolar Bob · Taken for 2 to 5 years August 16, 2015

“I can't take most antidepressants because they'll trigger a mixed, hypo, or total manic episode; for over 3 years, not this one. Only recently have I stopped from slipping into a mixed episode, but Wellbutrin XL @ 150 mg has helped keep balance when others caused chaos. No weight gain, increased sex drive, decreased appetite.”

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Toybreaker January 20, 2010

Wellbutrin (bupropion): “I have been annoyed all the time since I can remember. Always a pessimist. I figured if I expected the worst possible scenario anything better was a win. It was as if I was at war with the world, everything was a battle. Been on Welbutrin for 6 weeks now, 300mg a day in 2 doses to start. Gave me ridiculously bad headaches (I suffer from migraines already) but my mood, interest, and general sense of well being were better. Doc changed me from 2 doses to 3 doses a day (still 300 mg). No more headaches but slight insomnia so far. 3-4 hours a night now, usually get 6-7 hours of sleep. And I have the dry mouth as well. I will deal with the insomnia and cotton mouth. To me this is worth it.”

9 / 10
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mikrw33 · Taken for 2 to 5 years January 31, 2015

“This was the first antidepressant I responded to when I started it back in 2012. Initially it caused a little nausea, and again with each dose increase, but it was very mild and didn't last longer than a week. It brought me right up out of a deep, dark pit. At the time, I wasn't diagnosed with bipolar yet, so I wasn't taking any mood stabilizers. Once they realized I was, I was put on lamotrigine, and it has been a staple part of my medical regimen since then. I'm currently on 300 mg XL, and 400 mg lamotrigine ER. I recommend it to anyone who hasn't tried it yet!”

8 / 10
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kindle68 · Taken for 2 to 5 years October 12, 2018

“I am bipolar 2 and my symptoms are almost exclusively depressive. SSRIs ruined my life, as it induced rapid cycling. For bupropion 300mgXL. Game changer! I'm motivated, can concentrate, have lost weight and haven't cycled anymore. Totally recommend it. Just don't expect it to care for your anxiety. 100/10!”

10 / 10
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humanperson · Taken for 5 to 10 years October 20, 2020

“I was moving off Remeron about 6 years ago, having gained 30 pounds, and started taking bupropion at 75 mg to supplement my lamotrigine 200 mg. No real side effects, but also no real change. Then I got moved up to 150mg of bupropion. Sort of helped, but not quite. Moving up to 300 was a bit of a problem. I felt electric for the first two weeks, like I couldn't sit still and wanted to scream, and I was constantly uncomfortable in my own skin. I also kept having crazy vivid dreams and didn't sleep much. However, after those two weeks, I felt so much better. I was much better able to get up and on with my days, be productive, and generally get my life back. I will warn you: not usually suggested for bipolar, but my doctor and I discussed the risks. (I have since added other medications, though, due to life stressors and comorbid anxiety issues.)”

8 / 10
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rosethorn2011 September 2, 2009

Wellbutrin (bupropion): “I feel relatively "up" compared to how my lows used to be. My up times seem more productive and I have gained some interest in things I used to do i.e. painting. My lows still put me in a horrible state but I do not cry constantly like I used to. I am very happy with Wellbutrin.”

9 / 10
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Josh1447 November 27, 2017

“This drug has been a lifesaver to me. It's helped provide me with an antidepressant effect, whereas lithium only controlled the mania part of my mood. I use this in combination with other drugs and so far there hasn't been any side effects. Within 3 weeks the effects peaked. I would definitely recommend this drug. This has made a difference in my mood, the way I think, and my overall perspective. This improved my motivation to get work done, since I wouldn't be just sitting around reminiscing in a negative thought loop. It gives me mental freedom and allows me to escape brain fog that has imprisoned my thoughts. Seriously, don't be afraid to try this drug.”

9 / 10
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Anonymous · Taken for 6 months to 1 year June 21, 2019

“I started this medication bupropion to treat the depression of my bipolar type 2 disorder. It really works! My mood stabilized and my outlook on life significantly improved. However, I completely lost my appetite and got down to 96lbs. I’m a 25 year old woman and I’m now severely underweight. Bupropion is still worth it to me though. It helped me pick myself up and change my life.”

9 / 10
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Riley · Taken for less than 1 month March 10, 2020

“My doctor put me on bupropion XL 150mg and it was awful! Two weeks in I started having terrible anger and irritability spells to where I would just scream. After 17 days I had to stop taking it. The worst side effect I’m actually STILL having though since stopping is actually weight GAIN !?! I have even decreased my calories and increased my exercise to bring my weight back to normal but nothing is working! I’ve become so frustrated and my doctors are no help. Has anyone else experienced weight gain from this medication not related to overeating ? I am so desperate for answers :(”

1 / 10
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Deco · Taken for less than 1 month July 17, 2019

“I've been on this for almost 4 weeks. I am overweight as a result of other meds & emotional eating, which I do when depressed- for some reason especially when someone else is eating-- it's almost an impulse. I have lost five pounds now and find myself able to turn down sweets, be satisfied on normal portions, and generally able to control saying "No" to mindless and emotional eating. I can see why this would help smokers- I was becoming addicted to food. This alone has made me feel optimistic, but it was only after a couple of days that I began to notice certain other behaviors changing toward my self but more importantly others who deserved better from me. I hope that this proves to be what I need, I'm tired from trying so many other meds that haven't worked!”

8 / 10
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badblue March 23, 2016

“I started taking bupropion hcl 150mg about 3 weeks ago at the same time I quit useing zoloft 100mg, going off of zoloft was the hardest thing for me, it was hell, but I hung in there, today I am really happy that I'm off of it, and the bupropion at 300mg a day is excellent for me, no depression, sex drive back fully, it took about a week to adjust to, but I love it now, my mood is balanced to the level up to good mood too, so far no bad mood, no longer a zombie on zoloft, yay for me. just a tip for going off of zoloft, it gets bad, but in a few weeks it clears up, I almost gave up, but I'm glad I didn't, Again I feel alive , :)”

10 / 10
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soup August 10, 2020

“The first 2-3 weeks on this med bupropion were kind of horrible. I barely slept because I didn't feel like I needed to and then I ended up being sleep deprived and I wasn't sure if I could handle being on it. However, ever since I got used to it I have felt that Bupropion has been more helpful than the other 2 meds I had previously taken. It doesn't cover everything and I don't think any med could, but like I said this has been the most helpful med so far. I didn't give 10 stars though because in addition to the rough start if for some reason I don't have access to Bupropion for 3-4 days I start to feel very unstable.”

8 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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