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User Reviews for Bupropion

Also known as: Aplenzin, Budeprion, Budeprion SR, Budeprion XL, Buproban, Forfivo XL, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Learn more about Bupropion.

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20%(10)
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33%(17)
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16%(8)
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Bupropion Rating Summary

6.8/10 Average Rating

52 Ratings with 42 User Reviews

What next?Compare all 79 medications used in the treatment of Bipolar Disorder.

Reviews for Bupropion to treat Bipolar Disorder

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"This medication has been a major game changer for me. Before starting this medication, i was so severly depressed. I was taking other antidepressants at that time. They were helping to make me at least functional, most days just doing the bare minimum seemed too much. Eventually my PCP added 150 mg of Wellbutrin XL on top of the medication I was already taking. Since then we have up to 300 mg. I finally have energy, a desire to do things, and i feel the happiest i have been in a long time. Im not sure what kind of experiences other people have had on this medication, but since I have been on it I have had minimum negative side effects."

   
10

Snk88602 August 16, 2017

10 users found this comment helpful.
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"I'm giving this two stars because it helped me quit smoking, but that's all it did. I've been taking for almost two months now and my anxiety has greatly intensified. I also have muscle aches in my legs and back - not sure if it's related to the bupropion, but I didn't have these feelings before I started taking it. It did not help me lose weight, but I did finally plateau after gaining consistently on Paxil and Abilify. I'm still taking Abilify so maybe that's interfering with weight loss, I'm not sure. Also my depression was under control for awhile but with the relentless anxiety about everything, it's creeping back in. Everything feels like an effort and all I want to do is stay in bed all day. This medication is not for me."

   
2.0

TWG74 July 13, 2017

1 users found this comment helpful.
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"I take 300mg in the morning. At night I take trazadone 50mg. Like any drug I had many side effects at first. But this is definitely my favourite. My sex drive has increased significantly. My quality of life has improved in the sense that this medication has helped me to become higher functioning."

   
9.0

Zig77777 February 20, 2017

6 users found this comment helpful.
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"I am a 47 year old man and have been on several medications for my schizoaffective disorder and depression. My last antidepressant was Efexxor XR which killed my sex drive for several years. I suggested my Pdoc to try Wellbutrin XL and I shall say that that my sexual life increased from 1 to 10. I am very pleased with this medication and would recommend it to anyone."

   
10

chefhemaro (taken for 1 to 6 months) January 15, 2017

9 users found this comment helpful.
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"I have taken this medication on two separate occasions: first in conjunction with Seroquel (quetiapine) and Neurontin (gabapentin) and second by itself without other psychiatric medications. Both times I took the 150 mg extended release form. When I took it the first time I didn't experience any mood-altering effects, but I did lose a significant amount of weight. In fact, my psychiatrist had to take me off the medication when I dropped below 90 lbs. The second time I took bupropion was when I had to come off lithium due to thyroid damage. This time it was life changing. All of my depressive symptoms melted away without inducing any hypomania. I still lost weight, but not as much this time around. This medicine makes me feel normal again."

   
10

Bipolar2happy August 14, 2016

23 users found this comment helpful.
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"Wellbutrin 150mg; Within 36 hours I suffered from psychotic symptoms, ended that day with full blown mania and delusions. I barely remember something from that day. I remained extremely sound sensitive for another 10 days. An antipsychotic and benzo were needed to get me symptom free again. Never was psychotic before, diagnosed with BP 2"

   
1.0

Joyce_68 (taken for less than 1 month) August 6, 2016

12 users found this comment helpful.
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"Buproprion XL was helpful for a season when depression was hitting very hard with Bipolar. When I initially started taking it, I saw effects right away. I didn't notice any false happiness like many associate with "anti-depressants" but it lightened my mood which had been pretty depressed for some time. Over time I did notice the effect of the drug lessened and I did quit taking it, but it was helpful during the time I needed it. I had previously tried Zoloft and I found Buproprion superior to Zoloft in my personal experience."

   
9.0

Manuel231 (taken for 1 to 2 years) May 15, 2016

12 users found this comment helpful.
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"This drug has been a life saver more than once. I intend to stay on it forever. I have taken it for several extended periods 6-18 months at times at doses up to 450 mg per day. I've stopped and started but eventually my depression returns. On 150 mg per day, I feel horrible. I have the worst agitation inside where I feel like I could crawl out of my skin. I have a tightness in my chest that will not go away. I'm unable to sit and concentrate at work. On 300mg/day - it's like night and day from 150 mg. This is when I feel perfectly fine. The agitation disappears, and in fact, I almost feel sleepy. The chest tightness goes away and I'm able to sit and do my work for a full 8 hour day. I sleep amazing. On 450mg/day is when I feel "normal"."

   
9.0

Well-buddy (taken for 5 to 10 years) May 10, 2016

14 users found this comment helpful.
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"I started taking bupropion hcl 150mg about 3 weeks ago at the same time I quit useing zoloft 100mg, going off of zoloft was the hardest thing for me, it was hell, but I hung in there, today I am really happy that I'm off of it, and the bupropion at 300mg a day is excellent for me, no depression, sex drive back fully, it took about a week to adjust to, but I love it now, my mood is balanced to the level up to good mood too, so far no bad mood, no longer a zombie on zoloft, yay for me. just a tip for going off of zoloft, it gets bad, but in a few weeks it clears up, I almost gave up, but I'm glad I didn't, Again I feel alive , :)"

   
10

badblue March 23, 2016

23 users found this comment helpful.
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"My last medication Velafaxine stopped working thank God! I was on it for four months and in that time I gained more than fifty lbs. Seasonal depression, dry mouth, unsociable, and had no interest. I started Bupropion HCL tabs to 150 and had a few side affects. The one that was so hard has stayed is restless sleep that wakes me up really early. Dry mouth, shaking in the morning, constipation, drowsiness and I expect these should go away. But sleeping will be the hardest. I feel happy, doing projects, want to be with people, energetic, I'm back to charity running. And the weight is starting to come off. I was close to eating nothing with the other med. Give this a try. Gave my life back."

   
9.0

Rkpublic March 1, 2016

23 users found this comment helpful.
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"I'm 37 and have depression, usually seasonal, - sleeplessness, and occasional anxiety. I took 100 mg of Wellbutrin (and nothing else, it replaced zoloft at the time) for around 3-5 days. Within 2-3 days I was quite agitated, anxious and easily annoyed. By day five I stopped taking because I felt hostile and again annoyed. Cannot speak for others, but this one really made me a monster and I have never, not once, felt like that from any of these: zoloft celexa trazadone"

   
1.0

nicknamehasbeentaken December 22, 2015

15 users found this comment helpful.
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"Each person reacts differently to anti-depressants. This is input from both me and several other patients I have spoken to in the hospital and outpatient programs with similar accounts: Wellbutrin is a miracle drug for some people, but, especially if you are bipolar, you have to be extremely careful about the dosage. I've had severe depression symptoms for 10 years. After a month of starting, I didn't have what I would consider a moderate depressive episode for the next two months, and can now enjoy life again. But previously, I went on a dosage that was too high, and rapid cycled terribly. Communicate A LOT with your doctor. I DID have frustrating side effects, but they subsided. You can't just assume how a drug will work after two weeks."

   
9.0

Mk2349820934 September 1, 2015

22 users found this comment helpful.
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"I can't take most antidepressants because they'll trigger a mixed, hypo, or total manic episode; for over 3 years, not this one. Only recently have I stopped from slipping into a mixed episode, but Wellbutrin XL @ 150 mg has helped keep balance when others caused chaos. No weight gain, increased sex drive, decreased appetite."

Bipolar Bob (taken for 2 to 5 years) August 16, 2015

33 users found this comment helpful.
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"I have been on my antidepressants (celexa, lexapro, effexor, prozac, lithium, lamictal just to name a few) lexapro seemed to work best for me, however after a couple years its effects have reduced and I started to get angry, easily annoyed, and I always get tired around 3 or 4 pm and need a siesta so to speak. My Dr put me on Wellbutrin SR HCL 100mg once a day to try and combat the tiredness from the lexapro. It was filled with the generic version. I must say both my wife and I notice it has worked wonders for my anger and agitation, however I am twice as sleepy and groggy on it and have to take it before I go to sleep and when I get up I'm exhausted. Its doing the opposite of what almost every review I've seen for me. Im going off of it asap."

   
4.0

Merc99 (taken for less than 1 month) July 26, 2015

9 users found this comment helpful.
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"im 19 they put me on this originally for anxiety but apparently im bipolar according to the psych evaluation test. The first day on it i basically felt "high" since then Ive felt pretty great. I also take Gabapentin(for fibromyalgia) and prozac."

   
10

sparksrus (taken for 1 to 6 months) June 24, 2015

10 users found this comment helpful.
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"I was started on Wellbutrin about 2 months ago, along with Lamictal for mood-stabilization. I reluctantly got on it after a year free of meds (when I got hit with a bad case of Seasonal Depression beginning in fall and lasting through March and some of April, after a move to mostly gloomy Asheville, NC. I started off on half a tablet of 75mg regular release. Then I went up an extra half a tab. At first I thought it was great and then I started to feel low down again and went up to 150 mg. Slowly, I noticed feeling quite agitated and almost aggressive. I cut back down to just one tab and then half a tab and still the side-effects persisted, along with horrible anxiety and restlessness. So no more for me."

   
2.0

Cat66a (taken for 1 to 6 months) April 22, 2015

8 users found this comment helpful.
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"My doctor put me on this medication because I told him I get tired and moody throughout the day.. I had no plans to quit smoking cigarettes. I have been smoking for 5 years, 1/2 pack a day. After the 4th day, the cigarette kept on tasting worse and I couldn't even smoke a whole cigarette. Hopefully I just quit, it's best for me and my health. The cravings for cigarettes aren't there anymore. On the 3rd day, I felt really weak and light at work. Felt like I was going to throw up."

   
9.0

Tony! March 6, 2015

12 users found this comment helpful.
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"This was the first antidepressant I responded to when I started it back in 2012. Initially it caused a little nausea, and again with each dose increase, but it was very mild and didn't last longer than a week. It brought me right up out of a deep, dark pit. At the time, I wasn't diagnosed with bipolar yet, so I wasn't taking any mood stabilizers. Once they realized I was, I was put on lamotrigine, and it has been a staple part of my medical regimen since then. I'm currently on 300 mg XL, and 400 mg lamotrigine ER. I recommend it to anyone who hasn't tried it yet!"

   
8.0

mikrw33 (taken for 2 to 5 years) January 31, 2015

32 users found this comment helpful.
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"Started taking in 2007, weaned down to approximately 60 mg. per day (average). Has been the best antidepressant thus far, way better than Paxil, Zoloft and Prozac. Fewer side effects, and manages my mood disorder."

   
9.0

Mary255 May 28, 2014

22 users found this comment helpful.
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"When I had a dlifficult time getting a refill due to insurance issues, I missed a few days and talked to my doctor about trying to go without. I take Xanax ER 2mg and Lamictal 200mg both twice daily. I was fine for about 2 weeks. When I spiraled downward, it was bad. I ate, slept, and cried. I never missed a day of work, but I sure felt like running out of there. Finally, things worked out with insurance. I am actually glad to take a 3rd medication realizing how it helped me. It has been about 6 weeks since I took my last dose. I begin again tomorrow. So, my story can be summarized as depression and frustration levels returned within 2 weeks of stopping bupropion XL 300mg. Don't just stop!"

   
7.0

Ohmeohmy (taken for 2 to 5 years) April 28, 2014

21 users found this comment helpful.
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"I was put on Wellbutrin for smoking cessation, I had zero personal or family history of any mental health issues. The Wellbutrin did not work for smoking cessation, so my doctor took me off it abruptly. I suffered from the common on the Internet, but completely unheard of by doctors, Wellbutrin withdrawal symptoms of "brain zaps" or "brain shivers," odd sexual side effects, and powerful dreams. These adverse withdrawal effects from Wellbutrin were then misdiagnosed (according to the DSM) as bipolar. So in my case, Wellbutrin withdrawal effects were the etiology of a bipolar misdiagnosis."

   
1.0

Anybody November 7, 2013

16 users found this comment helpful.
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"I've been taking bupropion 450 mg/day, for at least five straight years. On two previous occasions, I would take it for a year or so and then refrain when things stayed sunny. Obviously they didn't remain that way, so this time around I'm firmly committed to it. I have had a tendency to rapid cycle. When I returned to bupropion the last time, the doctor also put me on Lamictal and Abilify. Last year, under her guidance, I weaned myself off of those. After all these years of dealing with BiPolar Disorder II, I am fairly well attuned to know when I might need to return to one or the other. I take bupropion, with food, soon after waking as it does interfere with sleep. I've had no other bothersome side-effects and no alcohol issues."

   
10

Male, 57 (taken for 5 to 10 years) September 1, 2013

48 users found this comment helpful.
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"I've been taking bupropion 200mg for roughly three weeks to treat Bipolar depression. I have not had success with any other antidepressants. For me, Wellbutrin has been great. It has increased my energy level dramatically, as well as improved my mood. It's not a cure all, but it's certainly helping. The side effects - I take it in the morning to avoid trouble sleeping. Increased my anxiety somewhat the first week. Higher libido. Markedly reduced appetite. I need to remind myself to eat, and I've lost 5 lbs. Others have mentioned a bad interaction with alcohol which I have not experienced. I've had up to three drinks with no problems. My overall experience has been good, this is a great medicine if it agrees with you."

   
9.0

male, 29 (taken for less than 1 month) January 31, 2013

68 users found this comment helpful.
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"It was actually pretty good. It gave me energy, suppressed appetite. Improved my ability to complete tasks and helped improve my mood. Did make my PMS worse. My pdoc took me off it because it was making my hair fall out."

   
8.0

Anonymous (taken for less than 1 month) June 29, 2012

20 users found this comment helpful.
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"I'm not sure yet what to think. I've been on 300 mg of Bupropion XL for one week and feel angry, edgy and cranky. "

   
5.0

Anonymous January 12, 2012

34 users found this comment helpful.
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