Trintellix for Major Depressive Disorder User Reviews (Page 5)

• Dee
• Taken for less than 1 month
• July 3, 2019

"I have switched to Trintellix about 2 weeks ago from Celexa, which I had been on for 10+ years. My sex drive is back, more vivid, colorful dreams, and just feeling so much more positive thoughts and overall good feeling!"

• Tracy
• Taken for 6 months to 1 year
• September 6, 2017

"I've been on Trintellix 20 mg for 10 months, 53-year-old female with long-standing, chronic MDD and anxiety since pre-teen years. Been on far too many antidepressants over the decades to list them all here. Been hospitalized a number of times, and in my 30s, resorted to ECT as a last resort, which did absolutely nothing. My psychiatrist says my MDD is very treatment-resistant. Antidepressants, even in high doses or combined, have no effect. But I do believe for once in my life, the Trintellix is making some difference for the better in me; it hasn't been a 'miracle' drug, but it does help! No nausea or side effects, either! Also on Xanax, trazodone for sleep, and 10 mg Adderall daily."

• SDano
• Taken for 1 to 6 months
• February 20, 2020

"I started Trintellix in the middle of January at 5 mg. The side effects were horrible. I remember that on the second day I vomited on the street while I was having a walk. I also had other side effects. After the first week, things started to change slowly for the better. After the second week, I took 10 mg. During the six weeks when I broke up with my boyfriend, everything fell apart. The medication stopped working and my depression got worse. I was on the way to kill myself. Everything was so serious and I decided to go back to my hometown where my family and therapist are. For 3 weeks I have been on Effexor XR, and I cannot say I see a positive change, but I feel hopeful that things will change for the better. I rate Trintellix a 2 because it had awful side effects and it didn't help me at the end. I wish luck to everyone reading this. You are not alone!"

• hbea
• Taken for 1 to 6 months
• May 14, 2015

"I only stopped taking this medication because I switched insurances, and the new company will not cover it at all! Being off of it, I realize what a huge difference this medication made. I took Trintellix for 4 months. I had some difficulty the first couple of weeks, to be honest, with sleep. Taking the medication in the evening made sense for me, I slept better versus taking it during the daytime, I slept worse. I ended up not needing to take any of my anti-anxiety pills after a month! My arousal was not hindered at all. Brilliant medication, thank you to whoever discovered this one."

• t-c
• Taken for 5 to 10 years
• June 24, 2024

"It seems to do everything the doctor said it would. I'm also on other medications. My mood was much better after adding Trintellix. One or more of my medications does cause ED. It is too expensive, and I'll probably drop it when I change my health insurance."

• MrsG
• Taken for 6 months to 1 year
• December 28, 2019

"So Trintellix was weird for me. 20 mg worked well for my depression but triggered some awful OCD episodes. If you have OCD or anxiety, you might want to stay away from this one. The nausea was not fun. Even when taken with a dose of Zofran (anti-nausea pill), my stomach would gurgle and churn all morning. I also had insomnia, and when I finally did fall asleep, I’d have weird and sometimes disturbing dreams. Positive things about it: I didn’t gain any weight and had no sexual side effects. Antidepressants are all different, and this particular one didn’t really work for me. But I will try as many as I have to until I find something that works."

• Autumn
• Taken for 1 to 2 years
• April 5, 2019

"I’ve read many of these posts. I too had nausea (would throw up within 15 minutes of taking the Trintellix pill, every single day). My doctor told me to take an anti-nausea med like Zofran (or generic) 30 minutes before I take this pill. It worked. No nausea at all if you follow that rule. Please try that if that’s your only hold-up. I’ve been on it about 2 years. I STILL have to take a Zofran 30 minutes before Trintellix, or I will puke. Also, take it around bedtime."

• Female
• Taken for 6 months to 1 year
• March 26, 2017

"I took all sorts of meds to test with the most horrible side effects. Finally, one day, my doc had me try Trintellix 20 mg, and my life changed. I read negative reviews and was scared, but I have had no side effects except for some weight gain. I had a family member that got severely sick, and I was by their bedside for 3 months. Though I would get depressed, I never had a dark dip (you know what I'm talking about), I bounced back quickly. I recommend trying this. Just try, and in a week you will know. The drug is super expensive. Use a coupon. Call the pharma company. See what happens... it may just change your life. Oh... I forgot to mention that I just started my own business after years of working for idiots and getting fired. I doubt I could do this without this med."

• Paula
• Taken for less than 1 month
• February 9, 2020

"I would give Trintellix a -100 if I could. My psychiatrist was telling me how great this drug was for all his other patients, but this was the worst drug I've ever taken. I would never recommend this, as I became severely depressed with daily thoughts of hurting myself and thoughts of suicide. I was literally crying every day until I was able to get off of this."

• Bipol...
• March 18, 2016

"I noticed a great improvement in my depression soon after introducing Brintellix to my other meds (Latuda, Lamictal, Xanax, Doxepin, Adderall). I also noticed it causes me nausea and vomiting! But I really like this one... hate that it makes me sick! Someone recommended putting it in peanut butter, and I think I'll try that because it works really well for me! I've taken my son out like every day, I couldn't be a 'good' mom before Brintellix! Like, seriously, I have never felt better! Vomiting sucks, though, I hate it... really hope peanut butter trick works!"

• Doing...
• Taken for 1 to 6 months
• December 22, 2017

"After having been on sertraline for years for MDD at increasingly higher doses and hence pesky side effects, I'd had enough, felt like I was crawling out of my skin with anxiety, which it was supposed to treat. Plus, I weighed more than I wanted to in spite of exercise and diet. Doc prescribed Trintellix, and holy cow, I will never take sertraline again. I have had no side effects, well, dry skin, but that I can manage. No brainy-type side effects, I don't feel sedated at all, but I do feel calm and no depression. No longer craving carbs. I only wish I'd known about this medicine sooner. I feel like myself! The pharmaceutical company has a 'loyalty program' for helping with the cost, do check it out."

• Cleob...
• Taken for less than 1 month
• September 14, 2018

"I had been on Lexapro for MDD, but I had gained weight and gotten to the point where I barely wanted to leave my house. I’m now on Trintellix, and I have a brighter mood and am more energetic and interested in life. I would recommend this drug. I haven’t had any of the gastrointestinal symptoms."

• Saved...
• January 7, 2017

"My husband had been on every drug and drug combo available-nothing worked for his anger, depression, and crippling anxiety. This has been a GODSEND! After 24 years of marriage, I finally feel like I found the loving, kind man I fell in love with. No side effects at all, much more stable moods, and soundly sleeping at night. He also takes Seroquel at bedtime."

• today...
• May 4, 2017

"This medication was a life changer for me. After struggling with debilitating depression and anxiety and trying several SSRIs, my pdoc did a gene test which uncovered that my body doesn't tolerate SSRIs, so he put me on Trintellix, which is an atypical antidepressant. I finally started feeling the light at the end of the tunnel. I started with 10 mg, upped to 20 mg. I am so grateful for my doctor for thinking outside the box and getting me on the road to recovery. The first few weeks, I did experience severe GERD and even took a PPI for it. But after a few weeks, it thankfully subsided. I started to see improvement after 8 weeks."

• Sailo...
• Taken for 2 to 5 years
• June 12, 2017

"30 years of battling depression - many medications over those years with either undesirable side effects (weight gain, 'flat-lining,' anxiety provoking), or meds that worked well only to lose efficacy over time. Trintellix is a blessing - I have used it since the 1st month it became available - highly compatible and effective, no side effects, and if anything, my mind seems a bit sharper. Only drawback - my private insurance treats it as a category III, so it is very, very expensive - even with the coupons, I still pay $258/month - but I won't go back to anything else."

• Sam
• Taken for less than 1 month
• January 1, 2021

"This medication Trintellix is the worst medication I have ever taken. I took it starting Nov 9 I only took it for 5 days before I ended up passing out on it. I started off at 5mg pills and during the time I took them I felt like I was high on speed. My pupils were wide, I was restless, paranoid, hallucinating, couldn’t sleep, zero appetite and nauseous. Eventually it all became too much and I passed out from one of the many severe panic attacks it gave me. The withdrawal even after only taking them for 5 days was terrifying. It felt like I was coming down off street drugs. It took almost 2 weeks to get back to myself!! Never again. Literally the worst nightmare of my entire life."

• Jade
• November 1, 2019

"After being on a variety of antidepressants for over 20 years, this is the best that I have taken. I feel so much better. I have had migraines, and I don’t get headaches anymore. The only drawback is I’m hungry all of the time, so I’m going to have to watch what I eat. If you’ve been on other meds and they have run their course, I hope that you try this when it works for you as well that is working for me. Currently on 10 mg a day."

• Anony...
• Taken for 1 to 2 years
• October 4, 2018

"I have severe MDD and PTSD. When I started Trintellix over a year ago, it was very helpful. However, the effects seem to have worn off a bit. That said, I haven’t noticed any negative side effects whatsoever and actually lost weight while on it, and it did work in the beginning. So I would recommend this drug, especially since it worked for me more than any other antidepressant and hasn’t come with any of the negative side effects."

• capta...
• Taken for 1 to 2 years
• May 14, 2016

"I have been on Brintellix for a year now, and this drug has definitely had a positive impact on my quality of life. The profound sadness that was my unwelcome partner for many years has, for the most part, dissipated. On most days, my mood is good, but the strange thing is that even though my mood is not depressed, I have little motivation to do activities that would bring me pleasure. I very rarely engage in hobbies, watch TV, read books, listen to audiobooks, or exercise, so I have a lot of free time in which I do nothing. Amazingly, my mood still remains relatively stable. But it is a frustrating mindset, and so I'm going to ask my psychiatrist to lower the Brintellix or adjust one of my four other psychotropic meds I also take daily."

• AMYZING
• Taken for 1 to 6 months
• April 7, 2019

"I have been on Lexapro for 20 years, then that stopped working, then I tried many others for my panic disorder. I also took a GeneSight test. It showed Trintellix would be a good match, and I have been on it for 6 weeks. So far, so good. I had been having panic and depression and depersonalization, which is extremely hard, but let's hope it gets better and better."

• prox
• Taken for 1 to 6 months
• November 18, 2014

"I've been on Brintellix for just over 2 months, and it's helped my depression tremendously. I've been on several SSRIs, and this is far and away the best one I've tried. It kicked in a little faster, and the lack of side effects is remarkable. I was irritable when I increased my dose from 5 mg to 10 mg, but it subsided after a month, and I took Klonopin as needed to help. I also noticed some mild scalp tingling, which another person mentioned. No sexual side effects, no weight gain, no TMJ, no night sweats! I'd recommend titrating up SLOWLY if you have anxiety/irritability (cut those annoying egg-shaped pills in half) and taking it with a meal to prevent nausea."

• Nadethi
• Taken for less than 1 month
• November 2, 2019

"I suffer from both depression and anxiety. I have been through hell the past 7+ months since paroxetine stopped working after many years of it being completely effective for me (as in took away all anxiety, obsessive thoughts, and depression). Since then, I have tried Lexapro, Prozac, and now Trintellix. I even took a GeneSight test that said Prozac and Trintellix will be metabolized normally for me. Well, 5 weeks on Prozac I was severely depressed and having suicidal thoughts, so I stopped taking it. Now, 3 weeks in on Trintellix, just 5 mg (I took my first 10 mg dose yesterday) and it's even worse. I am very agitated, can't eat anything-trying to eat makes me nauseous even though I'm hungry, can't sleep. I have more energy, but I'm also obsessing about whether my life is worth this. I can't relax, which I was at least able to do in the evenings when I wasn't taking any antidepressant. This is pretty bad, so I'm going to stop taking it. Discouraged again."

• tomsb...
• October 20, 2016

"I started taking it 8 days ago. I started to feel a little better each day. I did have nausea the first day. I noticed that when I get excited or run around too fast working, I get a little nausea, but not too bad and it passes when I calm myself. I'm very happy with the way it's working. Oh, and taking 10 mg."

• Noah...
• August 5, 2019

"I’ve been using Trintellix for almost three months. I started 10 mg for like 10 days, then increased to 20 mg. I’d like to share my experience with you guys. During those 3 months, I had these side effects: 1. Nausea: at the beginning for 12 days, then it’s gone. 2. Insomnia: at the beginning and continued for two weeks, then it’s gone. 3. Itching: started in the second month of using, but it lasted only for one week, and it’s gone. I don’t experience any changes in my weight. Right now I’ve completed 3 months of using, and I don’t have any side effects. My problem is that I don’t feel any improvement in my major depression."

• Don...
• September 14, 2022

"Horrible from beginning to end. I think you may be able to tell from the first few days on this one whether it's going to work. Crying the very next day over nothing. Repetitive thoughts. Hear a song and won't leave my head. Insomnia worsened week after week. Led to extremely suicidal thoughts. I was previously on zoloft for 25 years and tried switching. So this may be the cause. Oh and the cost... ridiculous!"