Trintellix for Major Depressive Disorder User Reviews (Page 4)

• Hum...
• Taken for 5 to 10 years
• April 14, 2021

"I have tried every single antidepressant on the market over the past 10 years. They either did not work or caused terrible side effects, or I needed a booster med, usually an antipsychotic, to make it work. I gained 60 lbs in 3 years taking other meds. My doctor at first gave me 5 mg of Trintellix and then upped me to 10. At 10 mg, I still needed the booster meds. She upped me to 15 mg and took me off the booster meds. I lost around 15 lbs and was feeling somewhat better. After upping me 6 weeks ago to 20 mg (maximum dose), I am feeling fantastic. Lots of energy, positive thoughts, enjoying life for the first time in 10 years. I have been on Trintellix in some form for almost 5 years, and it took that long to get the dosage right. I am grateful for my doctor for sticking with me until we finally found the right combination. I feel like I have a whole new life right now. Trintellix did not cause me weight gain. Abilify, Rexulti, and Bupropion XL did."

• Pay...
• Taken for less than 1 month
• October 12, 2018

"I have been on Zoloft for about 5 years with no problems. But recently, I started having panic attacks again, was always tired no matter how much I slept, couldn't enjoy life, and was having suicidal thoughts again, so my GP switched me to Trintellix. I'm about 2 weeks in, and so far, so good! Almost immediately, the suicidal thoughts stopped, and I actually have energy again. I am still struggling with not wanting to go out and do things, but am pushing through. I am very happy with the results so far. Side effects are mild nausea for a couple of hours after dosing and trouble sleeping. My head is feeling a little 'swimmy' at times too, but I think that may be from stopping Zoloft."

• Joh...
• Taken for 1 to 6 months
• May 14, 2024

"74-year-old white male (Retired MD) with multiple years of major depression. No meds until retired at age 70, then prescribed multiple medication treatments, settling on Trintellix 20 mg qam for 4 months. It took at least 3 months before noticing any change. Abilify 5 mg qam was added at 3 months, after which improvement in depression, attitude, and sleep patterns were noticed. During the first 2 months, experienced severe and frequent suicidal thoughts (wrote the letter twice), with no other side effects. If not for my 401k, I could not afford the $300 per month for Trintellix and $200 per month for Abilify. I have been contemplating stopping both medications and trying to manage without them. Unsure whether the depression of life is worse than the depression of depleting my hard-earned 401k. If I were single (widowed), I would definitely consider stopping the medications due to concerns about financial stability. Being old, depressed, and grumpy seems better than being old, depressed, and impoverished."

• Jos...
• Taken for 1 to 6 months
• July 26, 2019

"Had tried several other antidepressants and was close to giving up. Trintellix saved my life. I had increased energy and mood within a couple of weeks, started being able to be more active, and was able to think about the future without feeling overwhelmed. It was amazing. I've had depression for years and had forgotten what it felt like to actually be interested in life and not feel like dying every time I woke up in the morning. Side effects have been minimal: lots of nausea that has contributed to some weight loss but not enough to be worrisome, and it lowered my libido and made it slightly harder to orgasm. Compared to other things I tried, the side effects are hardly noticeable! BMI: 19.1, Trintellix 15 mg daily. I have noticed that if I miss a dose (I take it at night to reduce the nausea) and take it the next morning when I remember, I'm pretty irritable and down already just taking it 12 hours late. Overall, definitely recommend!!"

• Tir...
• May 6, 2017

"I have been battling major depression and anxiety for years and was at the point of saying this illness is meant to be my fatality. After several tries on different antidepressants, Trintellix has given me a new outlook on life. If you are at the point of tiresome trial and error, do not give up until you try Trintellix. The benefits outweigh the side effects."

• Ste...
• Taken for 1 to 6 months
• December 7, 2014

"I had no ill side effects with this medication. But, my doctor gave me samples, and when the samples were gone, my insurance wouldn't pay for the medication. I came off of it even though it worked because of the cost."

• apa...
• March 9, 2015

"1 month in and I'm tolerating this medicine really well. I have Bipolar Disorder, but I'm taking it for depression and anxiety. I'm currently taking 10mg. I have occasional diarrhea and nightmares (may be the Lamotrigine), but that's it. So far I'm feeling more optimistic, I'm making plans for the future, I want to go out and socialize more often, and feel much more calm. I've tried more antidepressants than I can count and have been taking them since 1991. This is by far the best so far."

• row...
• August 31, 2018

"I had tried Cipralex for a while when I was younger, and it helped with my depression, but the side effects were unpleasant and unhelpful. I had sexual dysfunction, blunted emotions, and a terrible crash after one beer, resulting in weeks of anxiety. I was off and barely scraping by without help for years when I finally saw a new doctor who listened to my story and recommended Trintellix. On the first day, I noticed my mood improve. Over the weeks, the residual anxiety vanished. I felt excited to wake up with the sun for the first time since childhood. The nausea was difficult to cope with, but if I take it before bed when already sleepy, I am asleep before the nausea starts. It helped my concentration a little, and we added Concerta to the mix. I still cry, but it's when I have a reason to now. Little things people take for granted, like vacuuming and doing laundry, are possible. It drained my savings, but it helped me feel ready to try again. I'm finally employed and getting somewhere again."

• Ott...
• February 2, 2016

"Tried many drugs over the past 20 years. This is the best yet. No strange feelings in the head, no twitching muscles or fog. Some stomach discomfort which was solved by splitting the 10-milligram tablet in two and taking morning and afternoon. The quality of my life has improved beautifully, and I am so grateful for it."

• Jen...
• Taken for less than 1 month
• May 6, 2017

"I have dealt with chronic depression most of my life, and I am 65 years young. I have been on so many pharmaceuticals over the years, starting at the age of 23 (Valium, Zoloft, Wellbutrin, Paxil, Buspar, Effexor, Pristiq, etc.) and Cymbalta for 15 years. Current dose is 90 mg daily (1-60 mg and 1-30 mg). I went to see a psychiatrist at my family practice doctor's suggestion; we felt I needed a change. I have also had fibromyalgia for 25 years plus and collected disability. Cymbalta has had the most longevity with me because it also managed my fibromyalgia. One month ago, I started on 5 mg of Trintellix. No side effects for 2 weeks. Then she bumped it up to 10 mg, and no side effects except exhausted. I removed 30 mg of Cymbalta, and it's been 2 weeks, and I feel great. I feel blessed – no side effects except being tired."

• MRG...
• Taken for less than 1 month
• October 13, 2018

"The first day I took my 5 mg dose, I began to experience minor bouts of dizziness every so often and a decrease in appetite, but figured I was just getting used to it and decided I'd wait it out to see if it improved. In just 3 days, I became severely dizzy, nauseated, and could no longer keep food down. I was disoriented and overwhelmed with an unusual feeling. I was basically unable to function and had to immediately stop the pills. Since then, my mood has tanked, and I've become irritable and aggressive and have had unusual and impulsive urges. I've never experienced anything quite like it and have seen a lot of other similar experiences. If you start this medicine, please inform yourself of the symptoms of serotonin syndrome! While it has done badly for me, some people are doing very well on this medication, so I can't in good conscience tell people not to try it. I wanted to share my personal experience and hope it informs people!"

• Anonymous
• Taken for 1 to 6 months
• April 14, 2023

"I've been on Trintellix for around 5 months, and I've had great results. When I started on the 5 mg, I definitely felt the nausea, but it went away after being on it for about a week and a half. The nausea only returned when my doctor upped my dosage to 10 mg, but it went away after around two weeks once my body got used to it. Since then, I've noticed a huge difference in my overall mood. I feel more stable, generally lighter, and happier, and the only other side effect I've experienced is very vivid dreams. They aren't unpleasant dreams at all, just incredibly vivid and the kind I always remember when I wake up. But overall, it really is like clouds have parted, I feel stable and hopeful again for the first time since I can remember."

• Bab...
• Taken for less than 1 month
• December 9, 2019

"I’ve been on the 5 mg for about a week now. I switched over from Zoloft because, after many years, it stopped working. So far, I have felt great. I haven’t had any nausea or adverse effects. I up my dose to 10 mg in a day or so, and I’ll update if I notice any changes, good or bad. So far, it’s been great though. I would say that the only effect I’ve noticed is my clothes are fitting differently. I haven’t weighed, but I think I’ve lost some weight! I’m pretty optimistic."

• LAN...
• Taken for 1 to 6 months
• September 23, 2020

"I had severe nausea. I would take Trintellix every morning, and within one hour after taking this medication, I was vomiting severely. It went on for a couple of months, and I had to be changed back to Lexapro! I was so disappointed because it made me feel better. Even after I would vomit, I was okay, so in order to keep taking the medication, I had to be put on and take Zofran every day. I didn't feel it was worth it, so I switched back to Lexapro. Has anyone else had these side effects? What should I do? Please help me out! Thanks."

• Tam...
• Taken for 1 to 6 months
• November 29, 2014

"I've had the side effects of nausea, diarrhea, and low sex drive. Even so, it has helped improve my mood and reduced my anxiety. The side effects have decreased in the past few weeks, but at first, they were bothersome. Largest complaint is the copay! Our cost is $122 after insurance! Outrageous. I probably won't be able to afford it for long. Sad because I finally found something that was working."

• Gio...
• December 16, 2014

"I was admitted into a clinic and was monitored for 3 weeks. After the 2nd day, I started feeling a change and after 4 weeks, it's still good. Energy levels are up, thinking positively and coping with society and life again. Only downfall for me is trouble sleeping. Two thumbs up!"

• Jef...
• July 9, 2015

"It is amazing. I have been on antidepressants on and off since I was 16 years old. I am now 19 and my life has completely changed around. My sleep is better, my appetite normal, my mood heightened, anxiety is away, and I don't feel as if there's something weighing down my heart. Please, if you are depressed right now, I highly recommend this medication. My dad has been using it too and he is genuinely happier with his life; I can see it in his eyes."

• Xan...
• October 16, 2016

"My doctor gave me Trintellix recently for MDD and anxiety disorder. I was on Viibryd on and off for 3 years, and it was not working for me anymore. I started Trintellix at 5 mg for 7 days and now I'm on 10 mg, day 5. I'm not crying anymore, my anxiety level is almost nothing, and I feel happier. The only side effects I got were nausea after taking the medicine for about an hour and itchiness. I had to take Benadryl. These passed after about two weeks. I do not feel clouded like most other SSRIs make you feel or tired. I just feel normal! I think this is a great medication."

• Coa...
• Taken for 2 to 5 years
• August 14, 2018

"For years I’ve experienced various forms of depression, including postpartum (PMDD) and MDD. My treatment regimen has included SSRI, SNRI, and Wellbutrin. To my dismay, none of these agents seemed to work for me, and as a result, my depression relapsed and my episodes were greater, even to the point of suicidal thoughts. Oftentimes, I would have talks with my psychiatrist that, while being on the prescribed medicine, “I don’t know how I’m supposed to feel.” Come to find out later, these feelings were a result of the medication not helping me. After a few years of complete misery and helplessness, Brintellix came along. My world changed. Within the first week, I was feeling complete. I was sleeping well, had more energy, and I also found interest in things again. The biggest improvement was my focus and concentration. More than 3 years later, I’m still on this drug and experienced absolutely no side effects."

• Ano...
• Taken for 1 to 6 months
• June 17, 2025

"I was looking for treatment for long-term depression/sadness/burnout, and here is what Trintellix (Brintellix as it is called here in Europe) did for me: - stopped extreme sadness and crying almost immediately, although I was told that it took longer for the medication to work - made me feel stronger (mentally) and more motivated to do things - decreased irritability - increased libido (no sexual side effects, for me) Here is what Trintellix did not do for me: - take away fatigue - take away mental chatter/invasive thoughts (although it did reduce the sadness of my thoughts) I was very resistant to take an SSRI, but once I did (10mg) and got over my initial fear, I was actually happy to take it. I was lucky to have no side effects, both when starting and tapering off. I have been off the medication for two weeks now, but am considering starting again as I have felt some of the symptoms coming. For me, being on Trintellix was a very positive experience."

• Deb...
• Taken for less than 1 month
• September 29, 2019

"Only on the Trintellix 5 mg for week #1. I feel better already. I was a failure of 2 different other antidepressants. I was losing my temper at work, wanting to get even with those who made me mad. I recognized that I needed a change as that was not me. My Dr. told me to take the medication with peanut butter, or at least with a meal, so I wouldn’t be sick as it is a side effect. I know I’m only in the first week, but I am getting back to me already, as noted in better hygiene on my days off, actually getting out of bed. I have started cleaning up my house again. Yes, it has given me diarrhea some, but I have no gallbladder, which also gave me diarrhea. Simple fix with incorporating yogurt into my daily diet. So far, I am very pleased with Trintellix. My insurance company, thankfully, will cover the medication because of the past failure of the previous 2 I have tried."

• Ain...
• Taken for 6 months to 1 year
• September 10, 2023

"For years, I have struggled with suicidal thoughts and countless antidepressants that absolutely did not help, and made me feel worse. I felt better within the first week of taking Trintellix. The only downside is I've been having joint pains caused by the medication, but it isn't as bad after I got my dosage increased to 20mg. Other than that, it helps a lot with my BPD as well! In my opinion, it helps with the rage episodes as well as paranoia to some extent. So not only does it make my MDD feel like it's barely there, but it's also making my BPD more manageable."

• Bob...
• February 1, 2015

"This medicine is amazing! I was on Viibryd for 2 years and still suffered, but now I feel 'normal' and am interested in life once again. I do have nausea and have trouble falling asleep, but those are tolerable; depression is difficult to tolerate."

• GTL...
• Taken for 1 to 6 months
• April 9, 2020

"I've tried citalopram, Effexor, Wellbutrin SR and XL, and Trintellix for anxiety issues, but all seemed to cause more anxiety and added depression than I had before I started taking them. Every time I stop taking them, I feel significantly better. Other negative side effects for Trintellix specifically included nausea (I had to stop eating specific foods, and because I was taking the medication with water, I felt sick every time I drank it throughout the day), lower sexual appetite (significantly, it was affecting my relationship), and lack of focus (I'm honestly lucky that I didn't lose my job the week before I stopped taking them). I know I've had anxiety my whole life, but the more I observe my issues, I'm fairly certain that the majority of my anxiety is caused by ADD."

• Cha...
• Taken for less than 1 month
• August 28, 2019

"Will probably update later when I’ve been on longer, but so far it’s been very helpful. I’ve been on several antidepressants over the last decade (only one has ever worked and had to be discontinued due to worsening side effects) and had no problem getting approval from insurance. I started on 5 mg for a week and had slight nausea on days 2-5 a couple of hours after taking with food that lasted about 20-30 minutes. I’ve been on 10 mg for a week and no nausea. It’s actually improved my IBS. Appetite has been the same. My depression symptoms mainly manifest as fatigue/exhaustion, brain fog, forgetfulness, lack of motivation. I feel great, I’m motivated, I’ve been working out, getting more done at work and at home, sleeping less (now I’m sleeping more like 8 hours instead of 10-12). My out-of-pocket is $100 for a 30-day supply of 10 mg, I’m looking into bringing the cost down, but if I can’t it’ll be well worth it for how good I feel."